49. 全身性エリテマトーデス Systemic lupus erythematosus Clinical trials / Disease details

臨床試験数 : 993 / 薬物数 : 702 - (DrugBank : 184) / 標的遺伝子数 : 116 - 標的パスウェイ数 : 200

21 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05057481 (ClinicalTrials.gov)	September 15, 2021	16/9/2021	Reappraisal of the Therapies of Refractory Autoimmune Hemolytic Anemia in Systemic Lupus Erythematos ...	Reappraisal of Second-line Therapies of Refractory Autoimmune Hemolytic Anemia in Systemic Lupus Ery ...	Autoimmune Hemolytic Anemia;Systemic Lupus Erythematosus	Drug: Mycophenolate Mofetil 500mg;Drug: Rituximab	Assiut University	NULL	Active, not recruiting	18 Years	N/A	All	30	Phase 3	Egypt
2	NCT04127747 (ClinicalTrials.gov)	August 18, 2020	14/10/2019	Efficacy of Individualized Rituximabin Maintaining Remission of Moderate and Severe Systemic Lupus E ...	A Multicenter, Randomized Controlled Clinical Study About Efficacy and Safety of Standard Dose and I ...	Autoimmune Diseases	Drug: Standard dose of rituximab;Drug: Individualized dose of rituximab	Second Affiliated Hospital, School of Medicine, Zhejiang University	NULL	Recruiting	18 Years	65 Years	All	110	Phase 4	China
3	NCT05659407 (ClinicalTrials.gov)	July 24, 2020	13/12/2022	BAFF-var as a Biomarker of Response to B-depletive Treatment in Systemic Lupus Erythematosus and Rhe ...	The BAFF-var Polymorphism as a Biomarker of Response to B-depletive Treatment in Patients Affected b ...	Systemic Lupus Erythematosus;Rheumatoid Arthritis;BLyS Polymorphism	Drug: Belimumab in SLE patients / Rituximab in RA patients	University of Cagliari	Azienda Ospedaliero Universitaria di Cagliari	Recruiting	18 Years	N/A	All	60		Italy
4	NCT03747159 (ClinicalTrials.gov)	October 1, 2018	12/10/2018	Synergetic B-cell Immunomodulation in SLE - 2nd Study.	A Randomized Trial to Investigate the Reset of Humoral Autoimmunity by Combining Belimumab With Ritu ...	Lupus Erythematosus, Systemic	Drug: Belimumab Injection	Leiden University Medical Center	Dutch Kidney Foundation;GlaxoSmithKline	Recruiting	18 Years	N/A	All	70	Phase 2	Netherlands
5	EUCTR2018-001392-21-NL (EUCTR)	25/09/2018	25/09/2018	Synergetic B-cell immunomodulation in SLE – 2nd study	A randomized trial to investigate the reset of humoral autoimmunity by combining belimumab with ritu ...	systemic lupus erythematosus MedDRA version: 21.1;Level: LLT;Classification code 10042947;Term: Syst ...	Trade Name: belimumab or benlysta Trade Name: anti-CD20 B cell depletion with Truxima Product Name: tru ...	Leiden University Medical Center	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	30	Phase 2;Phase 3	Netherlands
6	NCT03312907 (ClinicalTrials.gov)	March 1, 2018	13/10/2017	A Study to Evaluate the Efficacy and Safety of Belimumab Administered in Combination With Rituximabt ...	A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 104-Week Study to Evaluate th ...	Systemic Lupus Erythematosus	Drug: Belimumab;Drug: Rituximab;Drug: Rituximab-placebo;Drug: Standard therapy (Including Immunosupp ...	GlaxoSmithKline	NULL	Completed	18 Years	N/A	All	292	Phase 3	United States;Argentina;Brazil;Canada;France;Germany;Korea, Republic of;Mexico;Netherlands;Russian F ...
7	EUCTR2016-003050-32-NL (EUCTR)	16/02/2018	24/10/2017	A Phase 3 Study to Evaluate the Efficacy and Safety of BelimumabAdministered in Combination with Rit ...	A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 104-Week Study to Evaluate th ...	Systemic Lupus Erythematosus (SLE) or Lupus MedDRA version: 21.1;Level: PT;Classification code 10042 ...	Trade Name: MabThera (Rituximab) Product Name: MabThera (Rituximab) INN or Proposed INN: RITUXIMAB Trade ...	GlaxoSmithKline Research & Development Ltd	NULL	Not Recruiting			Female: yes Male: yes	280	Phase 3	United States;Mexico;Canada;Argentina;Spain;Brazil;Russian Federation;Germany;Netherlands;Korea, Rep ...
8	EUCTR2016-003050-32-DE (EUCTR)	09/01/2018	21/06/2017	A Phase 3 Study to Evaluate the Efficacy and Safety of BelimumabAdministered in Combination with Rit ...	A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 104-Week Study to Evaluate th ...	Systemic Lupus Erythematosus (SLE) or Lupus MedDRA version: 21.1;Level: PT;Classification code 10042 ...	Trade Name: MabThera (Rituximab) Product Name: MabThera (Rituximab) INN or Proposed INN: RITUXIMAB Trade ...	GlaxoSmithKline Research & Development Ltd	NULL	Not Recruiting			Female: yes Male: yes	280	Phase 3	United States;Mexico;Canada;Argentina;Spain;Brazil;Russian Federation;Netherlands;Germany;Korea, Rep ...
9	EUCTR2016-003050-32-ES (EUCTR)	05/12/2017	01/12/2017	A Phase 3 Study to Evaluate the Efficacy and Safety of BelimumabAdministered in Combination with Rit ...	A Phase 3, Multi-Center, Randomized, Double-Blind, Placebo-Controlled, 104-Week Study to Evaluate th ...	Systemic Lupus Erythematosus (SLE) or Lupus MedDRA version: 20.0;Level: PT;Classification code 10042 ...	Trade Name: MabThera (Rituximab) Product Name: MabThera (Rituximab) INN or Proposed INN: RITUXIMAB Trade ...	GlaxoSmithKline, S.A.	NULL	Not Recruiting			Female: yes Male: yes	200	Phase 3	United States;Mexico;Canada;Argentina;Brazil;Spain;South Africa;Russian Federation;Netherlands;Germa ...
10	NCT03054259 (ClinicalTrials.gov)	September 21, 2017	17/1/2017	Rituximab Objective Outcome Measures Trial in SLE	A Feasibility Randomised Placebo-controlled Trial With Objective Outcome Measures to Evaluate the Ef ...	Systemic Lupus Erythematosus Arthritis	Drug: Rituximab;Drug: Methylprednisolone;Drug: Normal Saline	University of Leeds	NULL	Recruiting	18 Years	99 Years	All	30	Phase 2	United Kingdom

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