49. 全身性エリテマトーデス Systemic lupus erythematosus Clinical trials / Disease details
臨床試験数 : 993 / 薬物数 : 702 - (DrugBank : 184) / 標的遺伝子数 : 116 - 標的パスウェイ数 : 200
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05559671 (ClinicalTrials.gov) | February 7, 2023 | 26/9/2022 | Safety of the Herpes Zoster Subunit Vaccine in Lupus | A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Non-inferiority Crossover Study Evaluating the Safety and Immunogenicity of the Herpes Zoster Subunit Vaccine in Patients With Systemic Lupus Erythematosus | Systemic Lupus Erythematosus | Biological: Herpes Zoster Subunit (HZ/su) Vaccine;Biological: Placebo | NYU Langone Health | NULL | Not yet recruiting | 18 Years | 90 Years | All | 224 | Phase 4 | United States |
| 2 | NCT05236491 (ClinicalTrials.gov) | March 9, 2022 | 10/2/2022 | COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases | COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases | Rheumatoid Arthritis;Autoimmune Rheumatologic Disease;Systemic Lupus Erythematosus;Systemic Vasculitis;Systemic Sclerosis;Scleroderma;Undifferentiated Connective Tissue Diseases;Overlap Connective Tissue Disease;Immunosuppression | Biological: COVID-19 vaccine | Paul R Fortin | Canadian Institutes of Health Research (CIHR) | Recruiting | 18 Years | N/A | All | 287 | Phase 2/Phase 3 | Canada |
| 3 | NCT05000216 (ClinicalTrials.gov) | August 13, 2021 | 6/8/2021 | COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders | Booster Effects With Autoimmune Treatments in Patients With Poor Response to Initial COVID-19 Vaccine (ACV01) | Rheumatoid Arthritis (RA);Systemic Lupus Erythematosus (SLE);Pemphigus Vulgaris;Multiple Sclerosis (MS);Systemic Sclerosis (SSc);Pediatric SLE;Juvenile Idiopathic Arthritis (JIA);Juvenile Dermatomyositis (JDM);Pediatric-Onset Multiple Sclerosis (POMS) | Biological: Moderna mRNA-1273;Biological: BNT162b2;Biological: Ad26.COV2.S;Drug: Continue IS (MMF or MPA);Drug: Continue IS (MTX);Biological: Continue IS (B cell depletion therapy);Biological: Monovalent [B.1.351] CoV2 preS dTM-AS03;Drug: Withhold IS (MMF or MPA);Drug: Withhold IS (MTX);Drug: Withhold IS (B cell depletion therapy);Biological: Moderna mRNA-1273, Bivalent;Biological: BNT162b2, Bivalent | National Institute of Allergy and Infectious Diseases (NIAID) | Autoimmunity Centers of Excellence;Rho Federal Systems Division, Inc. | Recruiting | 2 Years | N/A | All | 2340 | Phase 2 | United States |
| 4 | NCT04516408 (ClinicalTrials.gov) | April 20, 2021 | 13/8/2020 | Recombinant Zoster Vaccine in Stable SLE Patients | Efficacy and Safety of Recombinant Zoster Vaccine in Stable SLE Patients(Vtrial) | Herpes Zoster;Recombinant Zoster Vaccine;Systemic Lupus Erythematosus | Biological: Recombinant zoster vaccine;Biological: Placebo | RenJi Hospital | NULL | Recruiting | 50 Years | N/A | All | 464 | N/A | China |
| 5 | NCT04839315 (ClinicalTrials.gov) | February 15, 2021 | 5/4/2021 | COVID-19 Vaccination in Rheumatic Disease Patients | Immunological Consequences of COVID-19 Vaccination in Patients With Rheumatic Diseases | Systemic Lupus Erythematosus;Sjogren's Syndrome;Inflammatory Myositis;Psoriatic Arthritis;Gout;Ankylosing Spondylitis;Arthritis of Multiple Sites Associated With Inflammatory Bowel Disease (Diagnosis);Osteoarthritis | Biological: mRNA COVD19 vaccine | Mayo Clinic | NULL | Terminated | 18 Years | N/A | All | 58 | Early Phase 1 | United States |
| 6 | NCT04726553 (ClinicalTrials.gov) | January 20, 2021 | 22/1/2021 | Nature of Anifrolumab Impact on Vaccine-Emergent Immunity in SLE | Nature of Anifrolumab Impact on Vaccine-Emergent Immunity in Patients With Moderately to Severely Active Systemic Lupus Erythematosus: A Multi-Centre Open Label Parallel Group Trial: | Systemic Lupus Erythematosus (SLE) | Drug: Anifrolumab;Drug: Standard of Care | Oklahoma Medical Research Foundation | NYU Langone Health;Yale University;Piedmont Heart Institute, Inc., Atlanta, GA;Columbia University | Recruiting | 18 Years | 70 Years | All | 20 | Early Phase 1 | United States |
| 7 | NCT03618056 (ClinicalTrials.gov) | December 19, 2018 | 1/8/2018 | Evaluating HIV-1 Neutralization Antibody Breadth in Response to HIV gp120 Protein Vaccine in HIV-uninfected Adults With Quiescent Systemic Lupus Erythematosus | A Phase 1b Open Label Clinical Trial to Evaluate HIV-1 Neutralization Antibody Breadth in Response to HIV gp120 Protein Vaccine in HIV-uninfected Adults With Quiescent Systemic Lupus Erythematosus | HIV Infections;Systemic Lupus Erythematosus | Biological: AIDSVAX® B/E | National Institute of Allergy and Infectious Diseases (NIAID) | NULL | Completed | 18 Years | 50 Years | All | 1 | Phase 1 | United States |
| 8 | NCT02477150 (ClinicalTrials.gov) | November 2015 | 17/6/2015 | Safety and Immunogenicity of a Zoster Vaccine in SLE | Immunogenicity and Safety of a Herpes Zoster Vaccine (Zostavax) in Patients With Systemic Lupus Erythematosus: a Randomized Controlled Trial | Systemic Lupus Erythematosus | Biological: Zostavax;Biological: placebo | Tuen Mun Hospital | NULL | Completed | 18 Years | N/A | All | 90 | Phase 4 | China |
| 9 | NCT02477254 (ClinicalTrials.gov) | July 2015 | 17/6/2015 | Long-term Immunogenicity of a HPV Vaccine in SLE | Long-term Immunogenicity of a Quadrivalent Human Papillomavirus (HPV) Vaccine in Patients With Systemic Lupus Erythematosus: a Case-control Study | Systemic Lupus Erythematosus | Biological: Vaccination | Tuen Mun Hospital | NULL | Completed | 18 Years | 35 Years | Female | 84 | N/A | China |
| 10 | NCT01741012 (ClinicalTrials.gov) | January 2013 | 14/11/2012 | Study to Determine if Gardasil Vaccine is Safe and Effective in Lupus Patients | Phase I, Safety and Immunogenicity of Gardasil® in Systemic Lupus Erythematosus. | Systemic Lupus Erythematosus | Drug: Gardasil | Wayne State University | Merck Sharp & Dohme Corp. | Completed | 18 Years | 50 Years | Female | 37 | Phase 1 | United States |
| 11 | NCT01687192 (ClinicalTrials.gov) | October 2012 | 13/9/2012 | Multicenter Trial Evaluating the Immunogenicity of HPV Vaccination in Girls on Immunosuppressive Therapy. | Multicenter Clinical Trial Evaluating the Immunological Response of Vaccination Against Infection by Human Papillomavirus (HPV) 6, 11, 16, 18 in Girls Receiving Immunosuppressive Therapy. | Transplantation;Systemic Lupus Erythematosus;Systemic Immune Disease | Biological: HPV prophylactic vaccine Gardasil | University Hospital, Bordeaux | NULL | Active, not recruiting | 9 Years | 18 Years | Female | 37 | Phase 2 | France |
| 12 | NCT01597492 (ClinicalTrials.gov) | May 31, 2012 | 8/5/2012 | A Study to Evaluate the Effect of Belimumab on Vaccine Responses in Subjects With Systemic Lupus Erythematosus (SLE) | A Phase 4, Multi-Center, Randomized, Open-Label Study to Evaluate the Effect of BENLYSTA™ (Belimumab; HGS1006) on Vaccine Responses in Subjects With Systemic Lupus Erythematosus (SLE) | Systemic Lupus Erythematosus | Biological: Belimumab plus Early Vaccination;Biological: Belimumab plus Late Vaccination | Human Genome Sciences Inc., a GSK Company | GlaxoSmithKline | Completed | 18 Years | N/A | All | 79 | Phase 4 | United States |
| 13 | NCT01474720 (ClinicalTrials.gov) | November 2011 | 15/11/2011 | Zostavax in Systemic Lupus Erythematosus | Immunologic Response to Varicella Zoster Vaccination With Zostavax in Patients With Systemic Lupus Erythematosus | Systemic Lupus Erythematosus | Drug: Zostavax vaccine | Oklahoma Medical Research Foundation | NULL | Completed | 50 Years | 75 Years | Both | 20 | Phase 1 | United States |
| 14 | NCT01151644 (ClinicalTrials.gov) | April 2010 | 25/6/2010 | Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases | Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases | Rheumatoid Arthritis;Spondyloarthritis;Systemic Lupus Erythematosus (SLE);Dermatomyositis (DM);DMixed Connective Tissue Disease;Systemic Vasculitis;Systemic Sclerosis (SSc);Sjögren's Syndrome;Antiphospholipid Syndrome;Juvenile Idiopathic Arthritis;Juvenile SLE;Juvenile DM | Biological: Anti-pandemic H1N1 influenza vaccine | University of Sao Paulo | Fundação de Amparo à Pesquisa do Estado de São Paulo | Active, not recruiting | N/A | N/A | Both | 5000 | Phase 4 | Brazil |
| 15 | NCT01006681 (ClinicalTrials.gov) | November 2009 | 31/10/2009 | Vaccination Against Influenza H1N1 in Rheumatic Diseases | Efficacy and Safety of Vaccination Against Influenza H1N1 in Patients With Rheumatoid Arthritis, Systemic Lupus Erythematosus, Psoriatic Arthritis and Ankylosing Spondylitis Treated With Immunomodulatory Drugs | Influenza;Rheumatic Diseases | Biological: Focetria (Monovalent MF59-Adjuvanted vaccine) | Tel-Aviv Sourasky Medical Center | NULL | Not yet recruiting | 18 Years | 65 Years | Both | 400 | Phase 2 | NULL |
| 16 | NCT00911521 (ClinicalTrials.gov) | October 2009 | 28/5/2009 | Immunogenicity and Safety of a Quadrivalent Human Papillomavirus (HPV) Vaccine in Patients With SLE: a Controlled Study | Immunogenicity and Safety of a Quadrivalent Human Papillomavirus (HPV) Vaccine in Patients With Systemic Lupus Erythematosus (SLE): a Controlled Study | Systemic Lupus Erythematosus | Drug: human papillomavirus vaccination (Gardasil) | Tuen Mun Hospital | NULL | Completed | N/A | 35 Years | Female | 100 | Phase 4 | China |
| 17 | NCT01072734 (ClinicalTrials.gov) | September 2009 | 19/2/2010 | Auto-immunity in Lupus Patients After Influenza Vaccine | Role of CXCR4/CXCL12 Axis on the Control of Humoral Immunity and Auto-immunity in Lupus Patients After Influenza Vaccine Challenge | Systemic Lupus Erythematosus (SLE) | Drug: Vaccine | Assistance Publique - Hôpitaux de Paris | Institut National de la Santé Et de la Recherche Médicale, France | Completed | 18 Years | N/A | Both | 28 | Phase 2 | France |
| 18 | NCT00786409 (ClinicalTrials.gov) | November 2008 | 5/11/2008 | Immunogenicity and Safety of HPV Vaccine Gardasil in Young Women | Immunogenicity and Safety of the Quadrivalent HPV Vaccine Gardasil in Female Systemic Lupus Erythematosus Patients Aged 9-26 | Systemic Lupus Erythematosus | Biological: Gardasil | University of Chicago | Merck Sharp & Dohme Corp. | Completed | 9 Years | 26 Years | Female | 27 | N/A | United States |
| 19 | NCT00611663 (ClinicalTrials.gov) | May 2008 | 28/1/2008 | Safety Study of Two Vaccine Strategies in Patients With Systemic Lupus Erythematosus | VACCILUP A Multicenter, Randomized Double-blind Trial Comparing Two Pneumococcal Vaccination Strategies in Patients With Systemic Lupus Erythematosus | Lupus Erythematosus, Systemic | Biological: Prevenar® and Pneumo23®;Biological: Placebo, Pneumo23® | Assistance Publique - Hôpitaux de Paris | NULL | Completed | 18 Years | 65 Years | Both | 47 | Phase 2/Phase 3 | France |
| 20 | EUCTR2007-004579-21-NL (EUCTR) | 27/08/2007 | 29/08/2007 | Does booster influenza vaccination improve vaccination efficacy in patients with quiescent systemic lupus erythematosus? | Does booster influenza vaccination improve vaccination efficacy in patients with quiescent systemic lupus erythematosus? | systemic lupus erythematosus (SLE)SLE is a systemic autoimmune disease. MedDRA version: 9.1;Level: LLT;Classification code 10025139;Term: Lupus erythematosus systemic | Trade Name: Influvac INN or Proposed INN: Influenz virus surface antigens Other descriptive name: INFLUENZA VACCINE (SURFACE ANTIGEN, INACTIVATED) | University Medical Center Groningen | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Netherlands |