60. 再生不良性貧血 Aplastic anemia Clinical trials / Disease details

臨床試験数 : 245 / 薬物数 : 318 - (DrugBank : 86) / 標的遺伝子数 : 44 - 標的パスウェイ数 : 166

16 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05031897 (ClinicalTrials.gov)	October 25, 2021	31/8/2021	Reduced-Intensity Conditioning for the Prevention of Treatment-Related Mortality in Patients Who Und ...	A 2 Step Approach to Haploidentical Transplant Using Radiation-Based Reduced Intensity Conditioning	Acute Lymphoblastic Leukemia;Acute Myeloid Leukemia;Aplastic Anemia;Chronic Lymphocytic Leukemia;Chr ...	Procedure: Hematopoietic Cell Transplantation;Drug: Mycophenolate Mofetil;Drug: Tacrolimus;Drug: Cycl ...	Thomas Jefferson University	NULL	Recruiting	18 Years	N/A	All	67	Phase 2	United States
2	NCT04403321 (ClinicalTrials.gov)	July 1, 2020	21/5/2020	Efficacy and Safety of Eltrombopag + Tacrolimusin Chinese Refractory or Relapsed Aplastic Anemia Pat ...	Efficacy and Safety of Eltrombopag + Tacrolimusin Chinese Refractory or Relapsed Aplastic Anemia Pat ...	Aplastic Anemia;Drug Effect	Drug: Tacrolimus;Drug: Placebo (for Tacrolimus)	Peking Union Medical College Hospital	NULL	Completed	14 Years	85 Years	All	114	Phase 2	China
3	NCT02918292 (ClinicalTrials.gov)	July 3, 2017	27/9/2016	Optimizing Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502)	Optimizing Haploidentical Aplastic Anemia Transplantation (CHAMP) (BMT CTN 1502)	Severe Aplastic Anemia	Drug: Antithymocyte Globulin (ATG);Drug: Fludarabine;Drug: Cyclophosphamide;Radiation: Total Body Ir ...	Medical College of Wisconsin	National Heart, Lung, and Blood Institute (NHLBI);National Cancer Institute (NCI);Blood and Marrow T ...	Completed	N/A	75 Years	All	32	Phase 2	United States
4	NCT02960646 (ClinicalTrials.gov)	January 18, 2017	8/11/2016	Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies	Phase I Clinical Trial Using an Engineered Peripheral Blood Graft for Haploidentical Transplantation ...	Acute Lymphoblastic Leukemia;Acute Myeloid Leukemia;Acute Myeloid Leukemia Arising From Previous Mye ...	Drug: Cyclophosphamide;Biological: Filgrastim;Drug: Fludarabine Phosphate;Other: Laboratory Biomarker ...	M.D. Anderson Cancer Center	National Cancer Institute (NCI)	Completed	18 Years	65 Years	All	11	Phase 1	United States
5	NCT02833805 (ClinicalTrials.gov)	September 2016	12/7/2016	NMA Haplo or MUD BMT for Newly Diagnosed Severe Aplastic Anemia	A Phase II Trial of Non-Myeloablative (NMA) Conditioning and Transplantation of Partially HLA-Mismat ...	Severe Aplastic Anemia;Aplastic Anemia;Bone Marrow Failure;Immunosuppression	Drug: Thymoglobulin;Drug: Fludarabine;Drug: Cyclophosphamide;Radiation: Total body irradiation;Drug: ...	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	NULL	Completed	N/A	N/A	All	21	Phase 2	United States
6	NCT02566304 (ClinicalTrials.gov)	November 13, 2015	30/9/2015	Reduced Intensity Chemotherapy and Radiation Therapy Before Donor Stem Cell Transplant in Treating P ...	A Two Step Approach to Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation for Pati ...	Acute Myeloid Leukemia;Acute Myeloid Leukemia in Remission;Aplastic Anemia;Chronic Myelomonocytic Le ...	Drug: Fludarabine;Radiation: Total-Body Irradiation;Biological: T Cell-Depleted Donor Lymphocyte Inf ...	Sidney Kimmel Cancer Center at Thomas Jefferson University	NULL	Recruiting	18 Years	N/A	All	35	Phase 2	United States
7	NCT02224872 (ClinicalTrials.gov)	August 2014	18/8/2014	Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With R ...	A Phase II Trial of Non-Myeloablative Conditioning and Transplantation of Partially HLA-Mismatched/H ...	Severe Aplastic Anemia;Bone Marrow Failure Syndromes	Procedure: Bone marrow transplant;Drug: Thymoglobulin;Drug: Fludarabine;Drug: Cyclophosphamide;Radia ...	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	NULL	Completed	N/A	73 Years	All	18	Phase 2	United States
8	NCT01760655 (ClinicalTrials.gov)	December 24, 2012	2/1/2013	Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk ...	A Two Step Approach to Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation for High ...	Acute Myeloid Leukemia With FLT3/ITD Mutation;Acute Myeloid Leukemia With Gene Mutations;Acute Myelo ...	Drug: Fludarabine phosphate;Drug: Busulfan;Radiation: Total-Body Irradiation;Biological: Therapeutic ...	Sidney Kimmel Cancer Center at Thomas Jefferson University	National Cancer Institute (NCI)	Completed	N/A	N/A	All	62	Phase 2	United States
9	NCT01659606 (ClinicalTrials.gov)	July 2012	6/8/2012	Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Con ...	Radiation- and Alkylator-free Hematopoietic Cell Transplantation for Bone Marrow Failure Due to Dysk ...	Dyskeratosis Congenita;Hoyeraal Hreidarsson Syndrome;Revesz Syndrome;Aplastic Anemia	Biological: alemtuzumab;Drug: Fludarabine;Drug: Cyclosporins;Drug: Mycophenolate mofetil;Drug: Tacrol ...	Boston Children's Hospital	Dana-Farber Cancer Institute;Children's Hospital Medical Center, Cincinnati;Children's Hospital Los ...	Active, not recruiting	30 Days	65 Years	All	40	Phase 2	United States;Norway;Sweden
10	NCT01529827 (ClinicalTrials.gov)	February 28, 2012	6/2/2012	Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral B ...	A Phase II Trial of Reduced Intensity Allogeneic Stem Cell Transplantation With Fludarabine, Melphal ...	Accelerated Phase Chronic Myelogenous Leukemia;Adult Acute Lymphoblastic Leukemia in Remission;Adult ...	Drug: fludarabine phosphate;Drug: melphalan;Radiation: total-body irradiation;Drug: tacrolimus;Drug: ...	Roswell Park Cancer Institute	NULL	Completed	3 Years	75 Years	All	94	Phase 2	United States

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