62. 発作性夜間ヘモグロビン尿症 Paroxysmal nocturnal hemoglobinuria Clinical trials / Disease details

臨床試験数 : 292 / 薬物数 : 151 - (DrugBank : 49) / 標的遺伝子数 : 22 - 標的パスウェイ数 : 108

11 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2021-004931-10-GR (EUCTR)	04/01/2023	22/11/2022	A study to examine the long-term safety, tolerability, and effectiveness of Pozelimab and Cemdisiran ...	An Open-Label Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of Pozeli ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	288	Phase 3	United States;Philippines;Taiwan;Greece;Thailand;Spain;Colombia;Italy;India;France;Jordan;Malaysia;P ...
2	EUCTR2020-002761-33-FR (EUCTR)	06/12/2022	21/03/2022	Efficacy and Safety of the Combination of Pozelimab and Cemdisiran versus continued Eculizumab or Ra ...	A RANDOMIZED, OPEN-LABEL ECULIZUMAB AND RAVULIZUMAB CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SA ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	140	Phase 3	Portugal;United States;Philippines;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;M ...
3	EUCTR2020-002761-33-DE (EUCTR)	20/06/2022	03/03/2022	Efficacy and Safety of the Combination of Pozelimab and Cemdisiran versus continued Eculizumab or Ra ...	A RANDOMIZED, OPEN-LABEL ECULIZUMAB AND RAVULIZUMAB CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SA ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	140	Phase 3	Portugal;United States;Philippines;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;M ...
4	EUCTR2020-004486-40-GR (EUCTR)	17/06/2022	08/04/2022	Ravulizumab-Controlled Study to Evaluate the Efficacy and Safety of Pozelimab and Cemdisiran Combina ...	A RANDOMIZED, OPEN-LABEL, RAVULIZUMAB-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF POZELI ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	124	Phase 3	Portugal;United States;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;Mexico;Canada ...
5	EUCTR2020-002761-33-GR (EUCTR)	17/06/2022	12/04/2022	Efficacy and Safety of the Combination of Pozelimab and Cemdisiran versus continued Eculizumab or Ra ...	A RANDOMIZED, OPEN-LABEL ECULIZUMAB AND RAVULIZUMAB CONTROLLED, NON-INFERIORITY STUDY TO EVALUATE TH ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	134	Phase 3	Portugal;United States;Philippines;Taiwan;Greece;Spain;Thailand;Turkey;Colombia;United Kingdom;Italy ...
6	EUCTR2020-002761-33-ES (EUCTR)	09/05/2022	11/03/2022	Efficacy and Safety of the Combination of Pozelimab and Cemdisiran versus continued Eculizumab or Ra ...	A RANDOMIZED, OPEN-LABEL ECULIZUMAB AND RAVULIZUMAB CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SA ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	140	Phase 3	Portugal;United States;Philippines;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;M ...
7	EUCTR2020-004486-40-ES (EUCTR)	09/05/2022	11/03/2022	Ravulizumab-Controlled Study to Evaluate the Efficacy and Safety of Pozelimab and Cemdisiran Combina ...	A RANDOMIZED, OPEN-LABEL, RAVULIZUMAB-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF POZELI ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	124	Phase 3	Portugal;United States;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;Mexico;Canada ...
8	EUCTR2020-002761-33-PL (EUCTR)	14/04/2022	22/03/2022	Efficacy and Safety of the Combination of Pozelimab and Cemdisiran versus continued Eculizumab or Ra ...	A RANDOMIZED, OPEN-LABEL ECULIZUMAB AND RAVULIZUMAB CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SA ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 21.1;Level: LLT;Classification code 100556 ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	140	Phase 3	Portugal;United States;Philippines;Taiwan;Greece;Spain;Turkey;Colombia;United Kingdom;Italy;France;M ...
9	EUCTR2020-005005-17-HU (EUCTR)	07/05/2021	05/03/2021	Pozelimab and Cemdisiran Combination Treatment in Adult Participants with Paroxysmal Nocturnal Hemog ...	A Randomized, Open-label, Two-arm Study to Evaluate the Safety, Efficacy, and Pharmacodynamic Effect ...	Paroxysmal Nocturnal Hemoglobinuria MedDRA version: 21.1;Level: LLT;Classification code 10055629;Ter ...	Product Name: Pozelimab Product Code: REGN3918 INN or Proposed INN: Pozelimab Product Name: Cemdisiran P ...	Regeneron Pharmaceuticals, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	24	Phase 2	Taiwan;Hong Kong;Hungary;Malaysia;United Kingdom;Korea, Republic of
10	EUCTR2016-002943-40-ES (EUCTR)	21/11/2016	30/09/2016	A Clinical Study with Investigational Drug, ALN-CC5, in patients with Paroxysmal Nocturnal Hemoglobi ...	A Phase 2, Open-label, Single Dose, Study of Subcutaneously Administered ALN-CC5in Patients with Par ...	Paroxysmal nocturnal hemoglobinuria (PNH) MedDRA version: 19.0;Level: LLT;Classification code 100556 ...	Product Code: ALN-CC5 INN or Proposed INN: ALN-62643	Alnylam Pharmaceuticals Inc	NULL	Not Recruiting			Female: yes Male: yes	15	Phase 2	Taiwan;Finland;Spain;Turkey;Austria;Russian Federation;Israel;United Kingdom;France;Czech Republic;C ...

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