64. 血栓性血小板減少性紫斑病 Thrombotic thrombocytopenic purpura Clinical trials / Disease details
臨床試験数 : 92 / 薬物数 : 85 - (DrugBank : 21) / 標的遺伝子数 : 18 - 標的パスウェイ数 : 76
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04588194 (ClinicalTrials.gov) | November 1, 2020 | 30/1/2020 | Romiplostim, Rituximab and Dexamethasone as Frontline Treatment for Immune Thrombocytopenia | Romiplostim in Combination With Low-dose Rituximab and High-dose Dexamethasone as Frontline Treatment for Immune Thrombocytopenia | Immune Thrombocytopenia;Thrombotic Thrombocytopenic Purpura | Drug: Romiplostim;Drug: Rituximab;Drug: Dexamethasone | David Gomez Almaguer | NULL | Recruiting | 16 Years | 90 Years | All | 12 | Phase 2 | Mexico |
| 2 | NCT04074187 (ClinicalTrials.gov) | October 21, 2019 | 14/8/2019 | A Trial of Caplacizumab in Japanese Patients With Acquired Thrombotic Thrombocytopenic Purpura (aTTP) | An Open-label Multicenter Trial to Study the Efficacy and Safety of Caplacizumab in Japanese Patients With Acquired Thrombotic Thrombocytopenic Purpura | Thrombotic Thrombocytopenic Purpura | Drug: Caplacizumab (ALX-0081);Drug: Plasma exchange (PE);Drug: Corticosteroid treatment (Methylprednisolone or prednisolone);Drug: Immunosuppressive treatment (eg, rituximab) | Sanofi | NULL | Completed | 18 Years | N/A | All | 21 | Phase 2/Phase 3 | Japan |
| 3 | EUCTR2017-001117-86-GB (EUCTR) | 25/07/2017 | 18/05/2018 | Elective rituximab in TTP | A phase IV, prospective, randomised single-blind UK multicentre non-inferiority trial of low-dose versus standard dose rituximab for prevention of relapses in acquired TTP - Elective rituximab in TTP | Acquired thrombotic thrombocytopenic purpura;Therapeutic area: Diseases [C] - Blood and lymphatic diseases [C15] | Trade Name: Mabthera Product Name: Mabthera | University College London | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 52 | Phase 4 | United Kingdom | ||
| 4 | JPRN-JMA-IIA00160 | 20/01/2014 | 16/01/2014 | Investigator Initiated Clinical Trial of Rituximab for Thrombotic Thrombocytopenic Purpura | Investigator Initiated Clinical Trial of Rituximab for Thrombotic Thrombocytopenic Purpura | Thrombotic Thrombocytopenic Purpura | Intervention type:DRUG. Intervention1:Rituximab, Dose form:INJECTION, Route of administration:INTRAVENOUS DRIP, intended dose regimen:1st cycle Initiate infusion at a rate of 50 mg/hr. In the absence of adverse events such as allergic reaction or infusion reaction, increase infusion rate by 50 mg/hr increments every 30 minutes, to a maximum of 400 mg/hr. Subsequent cycles If patients did not experience or experience grade 2 or less severe adverse events such as allergic reaction or infusion reaction during previous cycles, initiate infusion at a rate of 100 mg/hr and increase infusion rate by 100 mg/hr increments every 30 minutes, to a maximum of 400 mg/hr. If patients experience grade 3 or more severe adverse events such as allergic reaction or infusion reaction during previous cycles, initiate infusion at a rate of 50 mg/hr and increase infusion rate by 50 mg/hr increments every 30 minutes, to a maximum of 400 mg/hr.. | Saitama Medical University , Department of General Internal Medicine, Yoshitaka Miyakawa | NULL | Completed | >=20 YEARS | <=79 YEARS | BOTH | 8 | Phase 2 | Japan |
| 5 | NCT01554514 (ClinicalTrials.gov) | August 2012 | 8/3/2012 | Low Dose Rituximab in Thrombotic Thrombocytopenic Purpura | Adjuvant Low Dose Rituximab for Acquired TTP With Severe ADAMTS13 Deficiency | Thrombotic Thrombocytopenic Purpura | Biological: rituximab | Washington University School of Medicine | National Heart, Lung, and Blood Institute (NHLBI) | Completed | 18 Years | N/A | All | 19 | Phase 2 | United States |
| 6 | NCT00907751 (ClinicalTrials.gov) | May 2010 | 22/5/2009 | Rituximab in Adult Acquired Idiopathic Thrombotic Thrombocytopenic Purpura | Association of Rituximab to Plasma Exchange in Adult Acquired Idiopathic Thrombotic Thrombocytopenic Purpura | Thrombotic Thrombocytopenic Purpura | Drug: rituximab | Assistance Publique - Hôpitaux de Paris | NULL | Completed | 18 Years | N/A | Both | 12 | Phase 2 | France |
| 7 | EUCTR2010-018794-38-IT (EUCTR) | 23/02/2010 | 26/07/2010 | EVALUATION OF CLINICAL RESPONSE TO RITUXIMAB TREATMENT IN PATIENTS WITH ACQUIRED AUTOIMMUNE RECURRENT THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP) - RITUXIMAB IN RECURRENT TTP | EVALUATION OF CLINICAL RESPONSE TO RITUXIMAB TREATMENT IN PATIENTS WITH ACQUIRED AUTOIMMUNE RECURRENT THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP) - RITUXIMAB IN RECURRENT TTP | THROMBOTIC THROMBOCYTOPENIC PURPURA MedDRA version: 9.1;Level: LLT;Classification code 10037562 | Trade Name: MABTHERA INN or Proposed INN: Rituximab | FONDAZIONE IRCCS CA` GRANDA OSPEDALE MAGGIORE POLICLINICO DI MILANO | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Italy | ||||
| 8 | NCT00799773 (ClinicalTrials.gov) | April 2009 | 26/11/2008 | Evaluating the Effectiveness of Adding Rituximab to Standard Treatment for Thrombotic Thrombocytopenic Purpura (TTP) | STAR - Study of TTP and Rituximab, A Randomized Clinical Trial | Thrombotic Thrombocytopenic Purpura | Drug: Rituximab;Procedure: Plasma exchange;Drug: Corticosteroids | New England Research Institutes | National Heart, Lung, and Blood Institute (NHLBI);Genentech, Inc. | Terminated | 12 Years | N/A | All | 3 | Phase 3 | United States |
| 9 | NCT00531089 (ClinicalTrials.gov) | December 2007 | 17/9/2007 | Rituximab in Patients With Relapsed or Refractory TTP-HUS | A Phase II Study Evaluating the Efficacy of Rituximab in the Management of Patients With Relapsed/Refractory Thrombotic Thrombocytopenic Purpura (TTP) - Hemolytic Uremic Syndrome (HUS) | Thrombotic Thrombocytopenic Purpura;Hemolytic Uremic Syndrome | Drug: Rituximab | Hamilton Health Sciences Corporation | Canadian Apheresis Group;Hoffmann-La Roche;McMaster University | Recruiting | 18 Years | N/A | Both | 60 | Phase 2 | Canada |
| 10 | NCT00937131 (ClinicalTrials.gov) | March 2006 | 9/7/2009 | The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP) | A Study to Assess the Safety, Efficacy and Tolerability of Rituximab (Mabthera) in Combination With Plasma Exchange (PEX) in Patients With Acute Thrombotic Thrombocytopenic Purpura (TTP) | Thrombotic Thrombocytopenic Purpura (TTP) | Drug: Rituximab | University College, London | NULL | Active, not recruiting | 18 Years | 65 Years | Both | 40 | Phase 2 | United Kingdom |
| 11 | EUCTR2005-002274-30-GB (EUCTR) | 14/12/2005 | 04/11/2005 | A Study to assess the safety, efficacy and tolerability of Rituximab(Mabthera) in combination with Plasma Exchange in patients with Acute Thrombotic Thrombocytopenia Purpura. - The use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura. | A Study to assess the safety, efficacy and tolerability of Rituximab(Mabthera) in combination with Plasma Exchange in patients with Acute Thrombotic Thrombocytopenia Purpura. - The use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura. | Thrombotic Thrombocytopenia Purpura | Trade Name: MabThera Product Name: MabThera Product Code: IDEC-C2B8, Ro 45-2294 | University College London | NULL | Not Recruiting | Female: yes Male: yes | 40 | Human pharmacology (Phase 1): Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - (Phase 3): Therapeutic use (Phase 4): | United Kingdom | ||
| 12 | NCT00251277 (ClinicalTrials.gov) | November 2005 | 7/11/2005 | Use of Rituximab Treatment in Addition to Standard Care for Newly Presenting Thrombotic Thrombocytopenic Purpura | Use of Rituximab Treatment in Addition to Standard Care for Newly Presenting Thrombotic Thrombocytopenic Purpura | Thrombotic Thrombocytopenic Purpura | Drug: Rituximab | Weill Medical College of Cornell University | Genentech, Inc. | Withdrawn | 17 Years | N/A | Both | 0 | Phase 1/Phase 2 | United States |