70. 広範脊柱管狭窄症 Spinal stenosis Clinical trials / Disease details
臨床試験数 : 95 / 薬物数 : 169 - (DrugBank : 61) / 標的遺伝子数 : 68 - 標的パスウェイ数 : 90
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05630404 (ClinicalTrials.gov) | November 28, 2022 | 1/11/2022 | Efficacy of Surgical Injection Lumbar Erector Spinae Plane Block | Efficacy of Surgical Injection Lumbar Erector Spinae Plane Block for Pain Management Following Lumbar Spinal Fusion Surgery | Lumbar Spine Instability;Lumbar Spinal Stenosis;Lumbar Spine Degeneration | Drug: Surgical ESPB;Drug: US guided ESPB | Bursa City Hospital | NULL | Recruiting | 18 Years | 65 Years | All | 90 | N/A | Turkey |
| 2 | NCT05619848 (ClinicalTrials.gov) | October 25, 2022 | 9/11/2022 | Effect of Paravertebral Muscle Fat Infiltration on Rocuronium Use in Lumbar Surgery | Effect of Paravertebral Muscle Fat Infiltration on Rocuronium Use in Lumbar Surgery | Spinal Stenosis Lumbar | Drug: Rocuronium Bromide | Zheng Guo | NULL | Completed | 18 Years | 65 Years | All | 87 | Early Phase 1 | China |
| 3 | NCT05297513 (ClinicalTrials.gov) | July 2022 | 17/3/2022 | Efficacy of ActiveMatrix on Spinal SSI Rate | Efficacy of ActiveMatrix on Spinal Surgical Site Infection (SSI) Reduction: A Single-blinded Randomized Controlled Trial | Spinal Stenosis Lumbar;Surgical Site Infection;Back Pain Lower Back Chronic | Drug: ActiveMatrix | Baylor College of Medicine | Skye Biologics | Not yet recruiting | 18 Years | 100 Years | All | 275 | Phase 4 | NULL |
| 4 | NCT05345249 (ClinicalTrials.gov) | June 1, 2022 | 28/3/2022 | Erector Spinae Plane Block as Pain Management After Lumbar Fusion Surgery | Erector Spinae Plane Block for Reduction of Early Postoperative Pain Scores and Opioid Use in Lumbar Spinal Fusion Surgery, a Prospective Double-blinded Randomized Placebo-controlled Trial | Spondylolisthesis;Lumbar Disc Herniation;Lumbar Spinal Stenosis;Lumbar Disc Disease;Lumbar Spondylolisthesis;Lumbar Spondylosis;Lumbar Spine Disease;Lumbar Radiculitis;Spinal Fusion;Fusion of Spine;Spondylosis Lumbosacral Region | Drug: Ropivacaine Hydrochloride Injection;Drug: Sodium chloride | Maaike Fenten | Radboud University Medical Center | Recruiting | 18 Years | N/A | All | 76 | Phase 4 | Netherlands |
| 5 | NCT05392361 (ClinicalTrials.gov) | June 2022 | 18/5/2022 | Effect of Baclofen Treatment on Nocturnal Muscle Cramps in Patients With Lumbar Spinal Stenosis: a Randomized Clinical Trial | Effect of Baclofen Treatment on Nocturnal Muscle Cramps in Patients With Lumbar Spinal Stenosis: a Randomized Clinical Trial | Lumbar Spinal Stenosis With Nocturnal Calf Cramps | Drug: gabapentin (neurontin® capsule 300mg) treatment;Drug: baclofen (baclofen Tab. 10mg) treatment | Yonsei University | NULL | Recruiting | 19 Years | N/A | All | 40 | N/A | Korea, Republic of |
| 6 | ChiCTR2200058808 | 2022-04-16 | 2022-04-17 | Effect of multimodal brain monitoring-guided anesthesia on incidence of postoperative cognitive dysfunction in elderly following spinal surgery | Effect of multimodal brain monitoring-guided anesthesia on incidence of postoperative cognitive dysfunction in elderly following spinal surgery | Thoracic/lumbar spinal stenosis or lumbar disc herniation | BIS guided anesthesia management group:The dosage of propofol is adjusted guided by BIS value;Multimodal brain monitoring-guided anesthesia management group:Multimodal brain monitoring-guided anesthesia; | Beijing Municipal Geriatric Medical Research Center | NULL | Recruiting | 65 | 100 | Both | BIS guided anesthesia management group:94;Multimodal brain monitoring-guided anesthesia management group:94; | China | |
| 7 | NCT05029726 (ClinicalTrials.gov) | February 1, 2022 | 14/8/2021 | Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery | Randomized, Placebo-controlled Trial of Erector Spinae Plane Blocks (ESPB) for Perioperative Pain Management for Minimally Invasive (MIS) Lumbar Spine Surgery | Lumbar Spinal Stenosis;Lumbar Disc Herniation;Lumbar Spondylolisthesis;Lumbar Spondylosis;Lumbar Radiculopathy;Lumbar Spine Instability;Synovial Cyst;Degenerative Disc Disease;Degenerative Spondylolisthesis;Degenerative Intervertebral Discs | Drug: Bupivacaine-Epinephrine 0.25%-1:200,000 Injectable Solution plus clonidine;Drug: normal saline | John O'Toole | NULL | Recruiting | 18 Years | 80 Years | All | 125 | Phase 4 | United States |
| 8 | NCT02459392 (ClinicalTrials.gov) | December 31, 2021 | 26/5/2015 | EuroPainClinics® Study II (Prospective Trial) | EuroPainClinics® Study II (Prospective Randomized Double Blinded Trial) | Lumbar Spinal Stenosis | Other: Epiduroscopy;Drug: Hyaluronic Acid;Drug: DepoMedrol | Europainclinics z.ú. | NULL | Completed | 18 Years | N/A | All | 300 | N/A | Czechia;Czech Republic |
| 9 | NCT04992572 (ClinicalTrials.gov) | December 1, 2021 | 21/7/2021 | Study Comparing Local/ MAC Anesthesia in Lumbar Decompression | Randomized Study Comparing Local/ MAC Anesthesia to General for 1-3 Level Lumbar Decompressions | Lumbar Spinal Stenosis | Drug: Propofol Injection;Drug: Lidocaine Hydrochloride, Injectable | Stanford University | NULL | Recruiting | 40 Years | 95 Years | All | 100 | Early Phase 1 | United States |
| 10 | ChiCTR2100053054 | 2021-11-09 | 2021-11-10 | Desomumab and lumbar spinal stenosis | Evaluation of bone mineral density and function at 1 year after lumbar spinal stenosis and fusion with desomumab: a parallel double-blind randomized controlled clinical trial | Lumber disease | Group A:Denosumab;Group B:Placebo; | The First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology | NULL | Recruiting | 40 | 90 | Both | Group A:40;Group B:40; | Phase 4 | China |
| 11 | NCT05058287 (ClinicalTrials.gov) | November 5, 2021 | 9/8/2021 | Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression | Topical Epidural Steroid Usage in Patients Undergoing Posterior Lumbar Decompression: A Randomized Control Trial | Opioid Use;Lumbar Spinal Stenosis;Pain, Postoperative;Pain, Back | Drug: Depo-Medrol 40Mg/Ml Suspension for Injection;Drug: Placebo | Hospital for Special Surgery, New York | NULL | Recruiting | 18 Years | 85 Years | All | 150 | Phase 3 | United States |
| 12 | NCT04537026 (ClinicalTrials.gov) | June 16, 2021 | 28/8/2020 | Sterile Amniotic Fluid Filtrate Epidural Injection. | A Phase I/II Double-Blinded Randomized Prospective Study of Sterile Amniotic Fluid Filtrate Epidural Injection for the Treatment of Lumbosacral Radicular Pain Due to Spinal Stenosis: The SAFE Trial (Improving Safety and Outcomes in the Treatment of Pain and Disability Related to Spinal Stenosis). | Lumbar Spinal Stenosis | Drug: Amniotic Fluid Allograft;Drug: Dexamethasone sodium phosphate | University of Utah | Cell Therapy & Regenerative Medicine | Recruiting | 18 Years | N/A | All | 112 | Phase 1/Phase 2 | United States |
| 13 | ChiCTR2100046515 | 2021-06-01 | 2021-05-18 | To Evaluate the Clinical Efficacy of Zhuanyao Decoction in the Treatment of Degenerative Lumbar Spinal Stenosis Based on the Theory of 'Yanghua Qi' | To Evaluate the Clinical Efficacy of Zhuanyao Decoction in the Treatment of Degenerative Lumbar Spinal Stenosis Based on the Theory of 'Yanghua Qi' | Degenerative lumbar spinal stenosis | Treatment group:Zhuanyaotang Decoction granules + Mecobalamin tablets simulation agent+ Celecoxib capsules simulation agent;Control group:Methobalamin tablet + Celecoxib capsule + Zhuanyaotang Decoction granule simulation agent; | Wang Jing Hospital, Chinese Academy of Traditional Chinese Medicine | NULL | Recruiting | 45 | 70 | Both | Treatment group:52;Control group:52; | N/A | China |
| 14 | ITMCTR2100004862 | 2021-06-01 | 2021-05-18 | To Evaluate the Clinical Efficacy of Zhuanyao Decoction in the Treatment of Degenerative Lumbar Spinal Stenosis Based on the Theory of 'Yanghua Qi' | To Evaluate the Clinical Efficacy of Zhuanyao Decoction in the Treatment of Degenerative Lumbar Spinal Stenosis Based on the Theory of 'Yanghua Qi' | Degenerative lumbar spinal stenosis | Control group:Methobalamin tablet + Celecoxib capsule + Zhuanyaotang Decoction granule simulation agent;Treatment group:Zhuanyaotang Decoction granules + Mecobalamin tablets simulation agent+ Celecoxib capsules simulation agent; | Wang Jing Hospital, Chinese Academy of Traditional Chinese Medicine | NULL | Recruiting | 45 | 70 | Both | Control group:52;Treatment group:52; | N/A | China |
| 15 | NCT04483297 (ClinicalTrials.gov) | November 18, 2020 | 14/7/2020 | First-In-Human Study of AK1320 Encapsulated Microspheres (AK1320 MS) | First-In-Human Study of AK1320 Encapsulated Microspheres (AK1320 MS) In Subjects With Degenerative Spondylolisthesis and Concomitant Symptomatic Spinal Stenosis Who Are Undergoing Decompression And Single Level Instrumented Posterolateral Lumbar Autograft Fusion Surgery | Degenerative Spondylolisthesis;Spinal Stenosis | Drug: AK1320 MS;Other: Control | Asahi Kasei Pharma Corporation | Emergent Clinical Consulting, LLC | Active, not recruiting | 22 Years | 80 Years | All | 40 | Phase 1 | Canada |
| 16 | NCT04540068 (ClinicalTrials.gov) | October 2020 | 1/9/2020 | Prediction of TEI Success in Sciatica | Prediction Of Transforaminal Epidural Injection Success in Sciatica | Sciatica;Lumbar Disc Herniation;Lumbar Spinal Stenosis;Lumbar Radiculopathy | Drug: Transforaminal Epidural Injection | EJAVerheijen | Spaarne Gasthuis | Not yet recruiting | 18 Years | N/A | All | 538 | Netherlands | |
| 17 | NCT04492774 (ClinicalTrials.gov) | July 1, 2020 | 20/7/2020 | Degenerative Lumbar Stenosis Conservative Treatment | GOLDIC Therapy in Lumbar Degenerative Spinal Stenosis - Randomized Controlled Trial | Spinal Stenosis Lumbar;Spinal Canal Stenosis | Combination Product: Goldic serum;Drug: Steroid injections;Procedure: Manual therapy | Sutherland Medical Center | NULL | Active, not recruiting | 18 Years | N/A | All | 90 | Phase 4 | Poland |
| 18 | JPRN-jRCTs021200007 | 19/06/2020 | 03/06/2020 | MiroTAS | Efficacy and Safety of Mirogabalin for the Treatment as Add-On to NSAIDs in patients with Peripheral Neuropathic Pain caused by Lumbar Spinal Stenosis : Multi-institutional, randomized, open, parallel-design and interventional Study | Lumber Spinal Stenosis | Comparison in the effect and safety of Mirogabalin add-on therapy to NSAIDs and NSAIDs monotherapy for patients with Lumber Spinal Stenosis and administrated of NSAIDs. 1) NSAIDs monotherapy as a study drug are prescribed in accordance with a package insert and each of their administration and dosage is not changed while a study drug is administrated. 2) Mirogabalin add-on therapy to NSAIDs: NSAIDs as a study drug are prescribed in accordance with a package insert and each of their administration and dosage is not changed while a study drug is administrated. Mirogabalin is prescribed as follows in accordance with renal function of a subject. Patients with creatinine clearance more than 60mL/min: Mirogabalin is administrated in dose of 5mg twice a day at the first week. At the next week, Mirogabalin is administrated in dose of 10mg twice a day. At week 5(after Visit3), dose of Milogabalin is increased to 15mg twice a day unless there is no problem with the safety. After that, the dose of Mirogabalin is controlled by 10mg twice a day or 15mg twice a day depending on safety findings. Patients with creatinine clearance 30-60mL/min: Mirogabalin is administrated in dose of 2.5mg twice a day at the first week. At the next week, Mirogabalin is administrated in dose of 5mg twice a day. At week 5(after Visit3), dose of Milogabalin is increased to 7.5mg twice a day unless there is no problem with the safety. After that, the dose of Mirogabalin is controlled by 5mg twice a day or 7.5mg twice a day depending on safety findings. Also, more than 7 days washout period before enrollment is required for target patients administrated of prohibited drugs. If the administration of Mirogabalin is discontinued, down-titration is needed in accordance with the insert package. | Nikaido Takuya | NULL | Complete | >= 20age old | Not applicable | Both | 300 | N/A | Japan |
| 19 | EUCTR2019-003590-25-NL (EUCTR) | 15/06/2020 | 15/06/2020 | Epidural analgesia after back surgery | a Randomized controlled trial for epidural Analgesia for Pain relief after lumbar Interlaminar Decompressive spine surgery - RAPID - RAPID | Lumbar spinal stenosis MedDRA version: 21.0;Level: LLT;Classification code 10041595;Term: Spinal stenosis lumbar;System Organ Class: 100000004859;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Therapeutic techniques [E02] | Trade Name: Bupivacaïne HCl 0,125% / Sufentanil 50 µg flacon à 50 ml Product Name: Bupivacaine Product Code: Sufentanil | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 34 | Phase 4 | Netherlands | |||
| 20 | NCT04391855 (ClinicalTrials.gov) | May 10, 2020 | 13/5/2020 | Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Plus Ropivacaine for Pain Relief After Spine Surgery | Effect of Wound Infiltration With Tramadol, Dexmedetomidine, or Magnesium Sulfate as Adjuncts to the Local Anesthetic on Pain Relief After Spine Surgery | Analgesia;Pain, Postoperative;Spinal Stenosis;Spinal Disease | Drug: Tramadol with ropivacaine;Drug: Dexmedetomidine with ropivacaine;Drug: Magnesium with ropivacaine;Drug: Ropivacaine plus normal saline | Aristotle University Of Thessaloniki | NULL | Completed | 18 Years | 80 Years | All | 72 | Phase 4 | Greece |
| 21 | NCT04341831 (ClinicalTrials.gov) | April 15, 2020 | 8/4/2020 | Does Teicoplanin Powder Use In Lumbar Instrumentation Surgery Reduce Surgical Site Infection | Does Teicoplanin Powder Use In Lumbar Instrumentation Surgery Reduce Surgical Site Infection | Lumbar Spinal Stenosis;Lumbar Disc Herniation;Scoliosis Lumbar Region;Lumbar Spondylolisthesis;Lumbar Disc Lesion | Drug: Teicoplanin | Bezmialem Vakif University | NULL | Not yet recruiting | 18 Years | N/A | All | 120 | Phase 3 | NULL |
| 22 | ChiCTR2000028775 | 2020-02-01 | 2020-01-03 | Safety and effectiveness of pregabalin in the management of postoperative pain in lumbar surgery | Safety and effectiveness of pregabalin in the management of postoperative pain in lumbar surgery | 1. Lumbar disc herniation; 2. Lumbar spinal stenosis; 3. Lumbar spondylolisthesis | Pregabalin group: ?????????? ?????????? Postoperative analgesia with pregabalin;Celecoxib group: Postoperative analgesia with celecoxib; | The First Affiliated Hospital of Chongqing Medical University | NULL | Recruiting | 18 | 80 | Both | Pregabalin group:60;Celecoxib group:60; | China | |
| 23 | NCT04189341 (ClinicalTrials.gov) | January 10, 2020 | 3/12/2019 | Modified-Thoracolumbar Interfascial Plane Block and Erector Spinae Plane Block Following Lumbar Instrumentation Surgery | Ultrasound-Guided Modified-Thoracolumbar Interfascial Plane Block and Lumbar Erector Spinae Plane Block for Pain Management Following Lumbar Spinal Instrumentation Surgery | Lumbar Spine Instability;Lumbar Spinal Stenosis;Lumbar Disc Disease;Lumbar Spine Degeneration | Drug: Erector spinae plane block (Group E);Drug: Modified-thoracolumbar interfascial plane block | Medipol University | NULL | Withdrawn | 18 Years | 65 Years | All | 0 | N/A | Turkey |
| 24 | NCT04401735 (ClinicalTrials.gov) | November 1, 2019 | 11/5/2020 | Effects and Safety of Epidural PDRN vs. Placebo | Effects and Safety of PDRN (Polydeoxyribonucleotide) for Patient With Lumbar Spinal Stenosis Compared With Normal Saline in Randomized Placebo-Controlled Comparative Pilot Study | Spinal Stenosis Lumbar | Drug: Polydeoxyribonucleotides;Drug: Normal saline | Seoul National University Hospital | NULL | Recruiting | 19 Years | 80 Years | All | 45 | Phase 4 | Korea, Republic of |
| 25 | NCT04066296 (ClinicalTrials.gov) | September 8, 2019 | 3/7/2019 | Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine | A Double Blinded Randomized Control Trial in Outcomes for Lumbar Decompressions With Use of Liposomal Bupivicaine | Lumbar Spinal Stenosis | Drug: Liposomal bupivacaine | University of Colorado, Denver | NULL | Recruiting | 18 Years | N/A | All | 100 | Phase 2 | United States |
| 26 | NCT04611464 (ClinicalTrials.gov) | July 11, 2019 | 9/10/2020 | Misoprostol for Spinal Stenosis | Pain and Functional Outcomes With Misoprostol Treatment for Lumbar Spinal Stenosis | Lumbar Spinal Stenosis;Low Back Pain | Drug: Misoprostol | Dallas VA Medical Center | NULL | Completed | 18 Years | N/A | All | 23 | United States | |
| 27 | NCT03879447 (ClinicalTrials.gov) | June 24, 2019 | 5/3/2019 | Effectiveness and Safety of Korean Medicine for Low Back Pain or Sciatica Due to Lumbar Stenosis/Spondylolisthesis | Observational Study on the Effectiveness and Safety of Integrative Korean Medicine Treatment for Patients With Low Back Pain or Sciatica Due to Lumbar Stenosis or Spondylolisthesis | Lumbar Spinal Stenosis;Lumbar Spondylolisthesis;Low Back Pain;Sciatica;Neurogenic Claudication | Drug: Herbal medicine;Procedure: Chuna manual medicine;Procedure: Bee venom pharmacopuncture;Procedure: Pharmacopuncture;Procedure: Acupuncture;Procedure: Electroacupuncture;Procedure: Cupping;Procedure: Other intervention(s) | Jaseng Medical Foundation | NULL | Active, not recruiting | 19 Years | 75 Years | All | 110 | Korea, Republic of | |
| 28 | NCT04042948 (ClinicalTrials.gov) | June 24, 2019 | 13/7/2019 | Clinical Effect of Preventive Use of Tylenol on Fever After Removal of Drainage Tube in Lumbar Fusion Surgery | Randomized Controlled Study of Fever Probability, Risk Factors and Preventive Use of Non-steroidal Anti-inflammatory Drugs on Fever After Removal of Drainage Tube After Lumbar Fusion | Lumbar Spinal Stenosis;Lumbar Disc Herniation;Lumbar Radiculopathy | Drug: Tylenol | Peking University Third Hospital | NULL | Completed | 18 Years | N/A | All | 183 | N/A | China |
| 29 | NCT04007094 (ClinicalTrials.gov) | February 12, 2019 | 24/4/2019 | Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar Surgery | A Prospective, Single Arm Study of Patients Undergoing Posterolateral Lumbar Fusion (Without Interbody) Supplemented With ViviGen Cellular Bone Matrix | Degenerative Disc Disease;Spinal Stenosis;Spondylosis;Spondylolisthesis | Drug: ViviGen Cellular Bone Matrix | Ohio State University | DePuy Synthes | Recruiting | 18 Years | N/A | All | 50 | Phase 4 | United States |
| 30 | NCT03745040 (ClinicalTrials.gov) | January 26, 2019 | 5/11/2018 | Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion | Does Liposomal Bupivacaine Improve Postoperative Pain Control After One Level Posterior Spinal Fusion With Instrumentation | Lumbar Spinal Stenosis;Lumbar Disc Herniation;Lumbar Disc Disease;Lumbar Spondylolisthesis | Drug: Liposomal bupivacaine | Allina Health System | Twin Cities Spine Center | Recruiting | 18 Years | N/A | All | 60 | Phase 4 | United States |
| 31 | NCT04559295 (ClinicalTrials.gov) | November 21, 2018 | 31/8/2020 | Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs | Study of Bone of Marrow Concentrate (BMC) Injection in Discs, Facets, Sacroiliac Joints, and Epidural Space for Chronic Lower Back Pain With and Without Radiculopathy | Low Back Pain;Disc Disease;Disc Degeneration;Arthropathy Vertebrae;Sacral Disorder;Radiculopathy;Spinal Stenosis | Biological: Bone Marrow Concentrate | Stem Cures | NULL | Active, not recruiting | 18 Years | 60 Years | All | 80 | Phase 2/Phase 3 | United States |
| 32 | NCT03883022 (ClinicalTrials.gov) | September 3, 2018 | 10/3/2019 | Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery | Vancomycin Powder Combined With Autogenous Bone Graft as a Prevention for Post-operative Infection for Spine Surgery | Spinal Fusion;Spinal Stenosis;Spondylolisthesis | Drug: with U-VANCO (vancomycin hydrochloride);Drug: without U-VANCO (vancomycin hydrochloride) | Taipei Veterans General Hospital, Taiwan | NULL | Recruiting | 20 Years | N/A | All | 400 | N/A | Taiwan |
| 33 | NCT03801356 (ClinicalTrials.gov) | August 23, 2018 | 9/1/2019 | Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy | Defining the Threshold Response of Lumbar Selective Nerve Root Block in Predicting Good Outcome Following Lumbar Foraminotomy | Back Pain;Radiculopathy Lumbar;Degenerative Lumbar Spinal Stenosis | Drug: Selective Nerve Root Block | The Cleveland Clinic | Lumbar Spine Research Society | Recruiting | 18 Years | 80 Years | All | 50 | Phase 4 | United States |
| 34 | ChiCTR1800016968 | 2018-07-15 | 2018-07-05 | A prospective study on the effect of different antiosteoporosis drugs on patients after lumbar fusion surgery | A prospective study on the effect of different antiosteoporosis drugs on patients after lumbar fusion surgery | Osteoporosis with lumbar spinal stenosis | C:Lumbar Fusion Surgery+Basic anti-osteoporosis drugs;A:Lumbar Fusion Surgery+MenatetrenoneSoft Capsules;B:Lumbar Fusion Surgery+Teriparatide acetate; | Qilu Hospital of Shandong University | NULL | Recruiting | 20 | 80 | Both | C:40;A:40;B:40; | China | |
| 35 | NCT03584074 (ClinicalTrials.gov) | July 1, 2018 | 29/6/2018 | Clinical Trial of Pregabalin and COX2 in Spinal Stenosis | Comparative Study for Decrease of Pain Intensity and Pain Sensitivity Between Pregabalin + COX-2 Inhibitor and COX-2 Inhibitor in Patients With Lumbar Spinal Stenosis: Randomized Controlled Trial | Spinal Stenosis Lumbar | Drug: Pregabalin 75mg;Drug: Celebrex 200Mg Capsule | Seoul National University Bundang Hospital | NULL | Unknown status | 40 Years | N/A | All | 60 | Phase 4 | NULL |
| 36 | JPRN-JapicCTI-183866 | 02/2/2018 | 15/02/2018 | Placebo-controlled, double-blind, exploratory study of NS-304 in lumbar spinal stenosis (LSS) patients with intermittent claudication (Early Phase II study) | Placebo-controlled, double-blind, exploratory study of NS-304 in lumbar spinal stenosis (LSS) patients with intermittent claudication (Early Phase II study) | LSS | Intervention name : NS-304 INN of the intervention : Selexipag Dosage And administration of the intervention : Oral administration Control intervention name : NS-304 Placebo INN of the control intervention : - Dosage And administration of the control intervention : Oral administration | Nippon Shinyaku Co., Ltd. | NULL | complete | 40 | 79 | BOTH | 120 | Phase 2 | Japan |
| 37 | JPRN-UMIN000030881 | 2018/01/18 | 18/01/2018 | Dietary supplementation in patients following lumbar spine surgery: a randomized controlled trial | Dietary supplementation in patients following lumbar spine surgery: a randomized controlled trial - Dietary supplementation in patients following lumbar spine surgery | lumbar spinal stenosis | Intervention group Twice-daily ingestion of amino acids supplementation for 3 weeks after spinal surgery (100kcal, protein 10g) Postoperative rehabilitation for 3 weeks Control group Twice-daily ingestion of placebo (non amino acids) supplementation for 3 weeks after spinal surgery (100kcal, protein 0g ) Postoperative rehabilitation for 3 weeks | Wakayama Medical University | NULL | Complete: follow-up continuing | 50years-old | 90years-old | Male and Female | 80 | Not selected | Japan |
| 38 | NCT03245671 (ClinicalTrials.gov) | December 2017 | 7/8/2017 | Particulate vs. Nonparticulate Epidural Steroid Injections for Lumbar Foraminal Stenosis | Particulate vs. Nonparticulate Epidural Steroid Injections for the Treatment of Symptomatic Unilateral Lumbar Foraminal Stenosis: a Prospective Double-blinded Randomized Study | Lumbar Spinal Stenosis | Drug: Kenalog Injectable Product;Drug: Decadron Phosphate, Injectable;Procedure: Epidural Steroid Injection | Hospital for Special Surgery, New York | NULL | Withdrawn | 18 Years | 90 Years | All | 0 | Phase 4 | United States |
| 39 | ChiCTR-INR-17012403 | 2017-09-01 | 2017-08-17 | Application of erythropoietin in enriched bone marrow stem cells technique to promote bone regeneration | Application of erythropoietin in enriched bone marrow stem cells technique to promote bone regeneration | bone defect, bone non-union and lumber spinal stenosis | treatment group:administer erythropoietin (150U/kg) three to five times via subcutaneous or intravenous injection before operation;controlled group:administer normal saline three times via subcutaneous or intravenous injection before operation; | Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine | NULL | Pending | 18 | 65 | Both | treatment group:44;controlled group:44; | China | |
| 40 | NCT03088306 (ClinicalTrials.gov) | July 1, 2017 | 22/2/2017 | Improving Pain and Reducing Opioid Use (IPaRO) in Lumbar Spine Surgery Patients | Comparative Effectiveness of Multi-modal Pain Management Versus Standard Intra- and Post-operative Analgesia: Randomized Controlled Clinical Trial to Reduce Post-operative Pain and Opioid Use Among Patients Undergoing Lumbar Spine Surgery | Lumbar Spinal Stenosis;Lumbar Spinal Instability;Lumbar Spine Degeneration | Drug: Standard analgesia use [Oxygen];Drug: Standard analgesia use [Hydromorphone];Drug: Standard analgesia use [Volatile Anesthesia];Drug: Standard analgesia use [Fentanyl];Drug: Multi-modal pain management [Acetaminophen + Gabapentin];Drug: Multi-modal pain management [Fentanyl];Drug: Multi-modal pain management [Intravenous Ketamine];Drug: Multi-modal pain management [Valium + Gabapentin] | Johns Hopkins University | North American Spine Society | Completed | 18 Years | 100 Years | All | 49 | Early Phase 1 | United States |
| 41 | NCT02975011 (ClinicalTrials.gov) | March 4, 2017 | 22/11/2016 | Effectiveness and Safety of Korean Medicine for Lumbar Stenosis Patients With Sciatica | Observational Study on the Effectiveness and Safety of Integrative Korean Medicine Treatment for Patients With Sciatica Due to Lumbar Stenosis: Multicenter, Prospective, Single Group Observational Study | Lumbar Spinal Stenosis | Drug: Herbal medicine;Procedure: Chuna manipulation;Procedure: Bee venom pharmacopuncture;Procedure: Pharmacopuncture;Procedure: Acupuncture;Procedure: Electroacupuncture;Procedure: Cupping;Other: Other intervention(s) | Jaseng Medical Foundation | NULL | Terminated | 19 Years | 75 Years | All | 38 | Korea, Republic of | |
| 42 | NCT03011866 (ClinicalTrials.gov) | February 2017 | 16/12/2016 | Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries | Intravenous Versus Topical Use of Tranexamic Acid in Reducing Gross Hemorrhage and Transfusions of Spine Surgeries (TARGETS) : A Prospective, Randomized, Double Blind, Head-to-head Comparison Study | Spinal Stenosis;Intervertebral Disc Displacement | Drug: Wound topically irrigated with 500mg TXA;Drug: 1mg/kg/hr TXA intravenous infusion till the last suture | Peking Union Medical College Hospital | NULL | Not yet recruiting | 50 Years | N/A | All | 176 | N/A | NULL |
| 43 | EUCTR2016-002887-14-FI (EUCTR) | 31/10/2016 | 14/10/2016 | Dose-response of ketamine in patient controlled analgesia in orthopaedic surgery patients | Dose response study of Patient Controlled Analgesia (PCA) of S-ketamine in orthopaedic spine surgery patients - DoseRespKeta | Patients who are scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation MedDRA version: 19.0;Level: LLT;Classification code 10041595;Term: Spinal stenosis lumbar;System Organ Class: 100000004859;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11] | Trade Name: Ketanest-S INN or Proposed INN: KETAMINE Trade Name: Oxycodone Orion INN or Proposed INN: OXYCODONE | University of Turku | NULL | Not Recruiting | Female: yes Male: yes | 100 | Phase 1;Phase 4 | Finland | ||
| 44 | NCT02939482 (ClinicalTrials.gov) | October 1, 2016 | 15/10/2016 | A Study Comparison of Clinical Outcome After Different Rate of Infusion in Caudal Epidural Steroid Injection | A Prospective Study Comparison of Clinical Outcome After Different Rate Infusion in Caudal Epidural Steroid Injection | Spinal Stenosis;Lumbosacral Spondylosis;Radiculopathy | Drug: Triamcinolone Acetonide and normal saline solution | Navamindradhiraj University | NULL | Completed | 20 Years | N/A | All | 112 | N/A | Thailand |
| 45 | NCT02932020 (ClinicalTrials.gov) | October 2016 | 4/10/2016 | AlloGen-LI Treatment of Spinal Stenosis | Pilot Study Investigating the Utility of Epidural AlloGen-LI Injection for Treatment of Spinal Stenosis Symptoms | Low Back Pain | Drug: AlloGen-LI;Drug: depomedrol;Device: MRI;Drug: 0.5% marcaine | University of Southern California | Vivex Biomedical, Inc. | Withdrawn | 18 Years | N/A | All | 0 | N/A | United States |
| 46 | NCT02902380 (ClinicalTrials.gov) | September 27, 2016 | 6/9/2016 | The Effect of Dexmedetomidine on Neuroendocrine Stress Hormone Release and Heart Rate Variability in Patients Undergoing Major Spinal Surgery | Spinal Stenosis | Drug: dexmedetomidine group;Drug: control group | Yonsei University | NULL | Completed | 20 Years | 70 Years | All | 52 | N/A | Korea, Republic of | |
| 47 | EUCTR2015-002694-37-FI (EUCTR) | 01/09/2016 | 04/01/2016 | Dexmedetomidine is a drug that is used mainly for sedation in the intensive care unit. Purpose of this study is to determine does Dexmedetomidine infusion provide pain management in the postoperative period and prevent chronic pain. Patients are randomized to receive either placebo or dexmedetomidine infusion. DEXPAIN-study has been approved by Kuopio university hospitals ethics committee. | Dexmedetomidine infusion in pain management during low back surgeryDexmedetomidine is an alpha-2-adrenergic agonist that is used mainly for sedation in the intensive care unit. Alpha-2-adrenoceptors agonists have several beneficial actions in a surgical patient. They decrease symphatetic tone, reduce anesthetic and opioid requirements and cause sedation and analgesia. Pain after low back surgery is intense and can become chronic. We need a new drug to manage pain during postoperative period and to prevent chronic pain.DEXPAIN-study has been approved by Kuopio university hospitals ethics committee. Study is single centered, randomized and placebo-controlled study. A total of 60 patients scheduled for low back surgery will be enrolled in this study. Patients eligibility will be assessed by pre-determined inclusion-exclusion-criteria. Purpose of this study is to determine does Dexmedetomidine infusion provide pain management in the postoperative period and prevent chronic pain. Patients are randomized to receive either placebo or dexmedetomidine infusion. Patients in the dexmedetomidine group receive dexmedetomidine loading dose 1ug/kg for 10 minutes and continuous infusion 1.4 ug/kg/h during surgery and post-anesthesia care unit. Total infusion time will be four hours. Anesthesia is standardized and post-operative pain is treated with patient controlled analgesia made of oxycodone. Questionnaires will be used to assess pain control.Study is scheduled to start as soon as we obtain permission from Finnish Medicines Agency and receive sufficient funding. | Low back pain, Discus prolapse, Spinal stenosis;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | Trade Name: Dexmedetomidine Product Name: Dexdor INN or Proposed INN: DEXMEDETOMIDINE | Kuopio University hospital | NULL | Authorised-recruitment may be ongoing or finished | Female: no Male: yes | Finland | ||||
| 48 | NCT02700451 (ClinicalTrials.gov) | March 2016 | 18/2/2016 | Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes | A Randomized Controlled Trial of Post-operative Acetaminophen Versus Nonsteroidal Anti-Inflammatory Drug (NSAID) Use on Lumbar Spinal Fusion Outcomes | Lumbar Osteoarthritis;Spondylosis;Lumbar Disc Disease;Spinal Stenosis | Drug: Ketorolac;Drug: Acetaminophen;Drug: Placebo | Hospital for Special Surgery, New York | NULL | Active, not recruiting | 18 Years | 75 Years | All | 300 | N/A | United States |
| 49 | NCT02725723 (ClinicalTrials.gov) | March 2016 | 21/3/2016 | Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections | Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections | Spinal Stenosis | Device: Therm-AppTM TH, thermographic camera;Drug: epidural injection | Tel-Aviv Sourasky Medical Center | NULL | Not yet recruiting | 18 Years | 80 Years | Both | 40 | Phase 2/Phase 3 | NULL |
| 50 | NCT02625194 (ClinicalTrials.gov) | January 1, 2016 | 25/11/2015 | The Utility of Oxygen Insufflation During Flexible Fiberoptic Bronchoscope-guided Intubation | The Utility of Oxygen Insufflation During Flexible Fiberoptic Bronchoscope-guided Intubation | Lumbar Spinal Stenosis | Drug: Oxygen | Yonsei University | NULL | Completed | 20 Years | 60 Years | All | 36 | N/A | Korea, Republic of |
| 51 | NCT02444351 (ClinicalTrials.gov) | June 26, 2015 | 28/4/2015 | Botulinum Toxin Type A Injection Into the Gastrocnemius Muscle for Treatment of Nocturnal Calf Cramps in Patients With Lumbar Spinal Stenosis | Spinal Stenosis With Nocturnal Calf Cramps | Drug: botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle;Other: no intervention | Yonsei University | NULL | Completed | 20 Years | 80 Years | All | 50 | N/A | Korea, Republic of | |
| 52 | EUCTR2014-003252-31-FI (EUCTR) | 15/05/2015 | 22/04/2015 | Dose-response of dexmedetomidine in patient controlled analgesia in orthopaedic surgery patients | Dose response study of Patient Controlled Analgesia (PCA) of Dexmedetomidine in orthopaedic spine surgery patients - DoserespDex_2.0 | Patients, who are scheduled for elective posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation MedDRA version: 17.1;Level: LLT;Classification code 10041595;Term: Spinal stenosis lumbar;System Organ Class: 100000004859;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11] | Trade Name: Dexdor INN or Proposed INN: deksmedetomidiini Other descriptive name: DEXMEDETOMIDINE HYDROCHLORIDE Trade Name: Oxanest INN or Proposed INN: oksikodoni Other descriptive name: OXYCODONE HYDROCHLORIDE | University of Turku | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | Finland | ||||
| 53 | NCT02416804 (ClinicalTrials.gov) | January 2015 | 10/4/2015 | Postoperative Analgesia With Buprenorphine for Postoperative Pain Control and Quality of Life After Spinal Surgery | Postoperative Analgesia With Buprenorphine Transdermal System (BTDS) Versus Tramadol for Postoperative Pain Control and Quality of Life After Spinal Surgery | Spinal Stenosis;Pain, Postoperative | Drug: Buprenorphine;Drug: Tramadol | Seoul National University Hospital | NULL | Completed | 20 Years | N/A | All | 69 | Phase 4 | Korea, Republic of |
| 54 | JPRN-UMIN000015670 | 2014/11/12 | 12/11/2014 | Efficacy of epidural administration of ant-TNF-alfa and anti-interleukin-6 receptor antibody onto spinal nerve for treatment of sciatica. | Efficacy of epidural administration of ant-TNF-alfa and anti-interleukin-6 receptor antibody onto spinal nerve for treatment of sciatica. - Anti-Cytokine therapy for radicular pain (ACTRP) | low back and radicular leg pain caused by spinal stenosis were investigated. | 1% Xylocaine 1% Xylocaine + anti-TNF-alfa receptor antibody 1% Xylocaine + anti-interleukin-6 receptor antibody | Dept. of Orthopaedic Surgery, Graduate School of Medicine, Chiba University | NULL | Recruiting | 20years-old | 85years-old | Male and Female | 90 | Not selected | Japan |
| 55 | NCT02093520 (ClinicalTrials.gov) | May 2014 | 18/3/2014 | The MiDAS ENCORE Study | MILD® Percutaneous Image-Guided Lumbar Decompression Versus Epidural Steroid Injections in Patients With Lumbar Spinal Stenosis Exhibiting Neurogenic Claudication | Spinal Stenosis, Lumbar Region, With Neurogenic Claudication | Procedure: MILD Procedure;Drug: Epidural Steroid Injection | Vertos Medical, Inc. | NULL | Completed | 65 Years | N/A | All | 302 | N/A | United States |
| 56 | JPRN-UMIN000012918 | 2014/04/01 | 01/03/2014 | Long-term efficacy and safety of Limaprost for the treatment of Lumbar Spinal Stenosis | Long-term efficacy and safety of Limaprost for the treatment of Lumbar Spinal Stenosis - Long-term efficacy of Limaprost for LSS | Lumbar Spinal Stenosis | Limaprost alfadex(15 micro g/day), 1yrs. | Kansai LSS Forum | NULL | Pending | 50years-old | 80years-old | Male and Female | 300 | Not selected | Japan |
| 57 | NCT02070484 (ClinicalTrials.gov) | February 2014 | 21/2/2014 | Human Amniotic Tissue-derived Allograft, NuCel, in Posteriolateral Lumbar Fusions for Degenerative Disc Disease | Efficacy of a Human Amniotic Tissue-derived Allograft, NuCel, in Patients Undergoing Posteriolateral Lumbar Fusions for Degenerative Disc Disease | Lumbar Degenerative Disc Disease;Spinal Stenosis;Spondylolisthesis;Spondylosis;Intervertebral Disk Displacement;Intervertebral Disk Degeneration;Spinal Diseases;Bone Diseases;Musculoskeletal Diseases;Spondylolysis | Biological: NuCel;Biological: Demineralized Bone Matrix | OhioHealth | NuTech Medical, Inc | Terminated | 18 Years | 75 Years | All | 6 | N/A | United States |
| 58 | NCT02103543 (ClinicalTrials.gov) | January 2014 | 27/3/2014 | Comparison of the Order of Treatment in Lumbar Spinal Stenosis | A Randomized Trial in Patients With Lumbar Spinal Stenosis, Comparing the Order of Treatment With Epidural Corticosteroid Injections and Physical Therapy | Lumbar Spinal Stenosis | Other: physical therapy;Procedure: lumbar interlaminar epidural steroid injection;Drug: epidural steroid injection | Emory University | NULL | Withdrawn | 18 Years | 65 Years | All | 0 | N/A | United States |
| 59 | NCT01934868 (ClinicalTrials.gov) | December 1, 2013 | 30/8/2013 | Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg | A Comparison of the Long Term Outcomes of Prolotherapy Versus Interlaminar Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg | Sciatica;Spinal Stenosis of Lumbar Region;Degeneration of Lumbar or Lumbosacral Intervertebral Disc | Drug: prolotherapy solution of 20% dextrose;Drug: Epidural Steroid Injection | Hadassah Medical Organization | Reuth Rehabilitation Hospital | Active, not recruiting | 18 Years | 90 Years | All | 110 | Phase 4 | Israel |
| 60 | NCT01943435 (ClinicalTrials.gov) | November 20, 2013 | 8/9/2013 | Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis) | A Comparison of Non-Surgical Treatment Methods for Patients With Lumbar Spinal Stenosis | Lumbar Spinal Stenosis | Drug: NSAIDs; adjunctive analgesics; adjunctive anti-depressants;Procedure: Lumbar epidural injection;Other: Joint Mobilizations (spine, sacroiliac, hip);Other: Individualized exercises: clinical setting;Other: Group Exercise: community setting | Michael Schneider, DC, PhD | Patient-Centered Outcomes Research Institute | Completed | 60 Years | N/A | All | 259 | N/A | United States |
| 61 | NCT01995461 (ClinicalTrials.gov) | May 2013 | 18/11/2013 | Bilateral Transforaminal Epidural Steroid Injections for Degenerative Lumbar Spinal Stenosis | Effectiveness of Bilateral Transforaminal Epidural Steroid Injections in Degenerative Lumbar Spinal Stenosis Patients With Neurogenic Claudication: A Prospective Outcome Study | Spinal Stenosis, Lumbar Region, With Neurogenic Claudication | Drug: bilateral transforaminal epidural steroid injections | Marshfield Clinic Research Foundation | NULL | Terminated | 40 Years | 90 Years | All | 26 | N/A | United States |
| 62 | NCT01888536 (ClinicalTrials.gov) | February 2013 | 25/6/2013 | A Study to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis | A Randomized, Double-Blind, Comparative, Multi-Center, Phase ? Clinical Trial to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis | Neurologic Claudication in Patients With Lumbar Spinal Stenosis | Drug: Limaprost;Drug: Pregabalin;Drug: Placebo(for Pregabalin);Drug: Placebo(for Limaprost) | Yungjin Pharm. Co., Ltd. | NULL | Completed | 20 Years | 75 Years | Both | 182 | Phase 4 | Korea, Republic of |
| 63 | ChiCTR-TRC-13003639 | 2012-09-13 | 2013-09-07 | The application of Analgesia Nociception Index guided Remifentanil administration during general anesthesia for Spinal Surgery | The application of Analgesia Nociception Index guided Remifentanil administration during general anesthesia for Spinal Surgery | Lumbar spinal stenosis and/or lumbar intervertebral disc herniation | ANI group:ANI guide the administration of remifentanil;control group:remifentanil was adapted by Anaesthesiologist corresponding to clinical experiences ; | Peking University Third Hospital | NULL | Completed | 18 | 70 | Both | ANI group:30;control group:30; | China | |
| 64 | NCT02063035 (ClinicalTrials.gov) | August 2012 | 19/12/2013 | Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery | Topical Application of Tranexamic Acid to Reduce Postoperative Blood Loss in Posterior Approach Spinal Surgery | Lumbar Spinal Stenosis;Thoracic Spinal Stenosis | Drug: Tranexamic Acid;Drug: Placebo | Massachusetts General Hospital | NULL | Completed | 18 Years | 85 Years | All | 29 | Phase 4 | United States |
| 65 | NCT02090244 (ClinicalTrials.gov) | August 2012 | 16/3/2014 | Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans? | Förbättrar PTH Postero-lateral fusionsläkning Vid Ryggkirurgi? | Spinal Stenosis | Drug: Teriparatide | University Hospital, Linkoeping | Medical Research Council of Southeast Sweden | Completed | N/A | N/A | All | 34 | Phase 4 | Sweden |
| 66 | EUCTR2011-006152-36-DK (EUCTR) | 10/05/2012 | 10/05/2012 | Does postoperative treatment with parathyroidea hormone Forteo®improve the disability inelderly patients undergoing spinal stabilization fusion surgery comparedwith patients treated with placebo. If that is the case, is there a correlationbetween improvement of disability and solid osseous healing? | Postoperative treatment with parathyroidea hormone Forteo® inpatients undergoing posterolateral spinal fusion surgery. A prospektiveand a randomized double-blinded, placebo-controlled study - PTH-U-DESE-STUDY | Spinal stenosis MedDRA version: 14.1;Level: LLT;Classification code 10041597;Term: Spinal stenosis of lumbar region;System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders;Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05] | Trade Name: Forteo Product Name: Forsteo Product Code: 0002-8971 INN or Proposed INN: teriparatide [rDNA origin] contains recombinant human parathyroid hormone (1-34) Other descriptive name: rhPTH (1-34) | Middelfart Rygsektor | NULL | Not Recruiting | Female: yes Male: yes | 100 | Phase 2 | Denmark | ||
| 67 | NCT02271191 (ClinicalTrials.gov) | May 2012 | 15/10/2014 | Effect of Nicardipine on Renal Function in Deliberate Hypotension | Effect of Nicardipine on Renal Function in Deliberate Hypotension | Spinal Stenosis | Drug: Nicardipine | Yonsei University | NULL | Completed | 20 Years | N/A | Both | 64 | Phase 4 | NULL |
| 68 | EUCTR2012-000747-26-FI (EUCTR) | 27/04/2012 | 02/04/2012 | Ketamine to reduce postoperative pain in back surgery | Administration of S-Ketamine during spinal surgery to reduce postoperative pain | adult patients undergoing spinal surgery MedDRA version: 14.1;Level: LLT;Classification code 10041595;Term: Spinal stenosis lumbar;System Organ Class: 10028395 - Musculoskeletal and connective tissue disorders ;Therapeutic area: Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03] | Trade Name: Ketanest-S Product Name: Ketanest-S Other descriptive name: ESKETAMINE HYDROCHLORIDE | Helsinki Universiy Central Hospital | NULL | Not Recruiting | Female: yes Male: yes | 192 | Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (Phase 3): no Therapeutic use (Phase 4): yes | Finland | ||
| 69 | JPRN-UMIN000007419 | 2012/04/01 | 01/04/2012 | A Prospective, Randomized, Multicenter Trial of Pregabalin and Celecoxib for Lumbar Spinal Stenosis | A Prospective, Randomized, Multicenter Trial of Pregabalin and Celecoxib for Lumbar Spinal Stenosis - A Prospective, Randomized, Multicenter Trial of Pregabalin and Celecoxib for Lumbar Spinal Stenosis | Lumbar Spinal Stenosis | Celecoxib Pregabalin | Department of Orthopedic Surgery Kobe University Graduate School of Medicine | NULL | Pending | 50years-old | 90years-old | Male and Female | 80 | Not selected | Japan |
| 70 | NCT01618435 (ClinicalTrials.gov) | March 2012 | 8/5/2012 | The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis | The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation | Spinal Stenosis | Biological: i-FACTOR | Sygehus Lillebaelt | CeraPedics, Inc | Active, not recruiting | 60 Years | N/A | Both | 108 | Phase 3 | Denmark |
| 71 | NCT01522846 (ClinicalTrials.gov) | January 2012 | 9/1/2012 | Heparin Solution and INTEM/HEPTEM Analysis | Influence by Heparinized Flush Solution of the Radial Artery Catheter: INTEM and HEPTEM Analysis. | Brain Tumor;Spinal Stenosis;Cerebral Artery Anuerysm | Drug: Heparin | Seoul National University Bundang Hospital | NULL | Completed | 20 Years | N/A | Both | 25 | N/A | Korea, Republic of |
| 72 | NCT02257723 (ClinicalTrials.gov) | January 2012 | 2/10/2014 | The Effect of Integrated CAM Treatment in Hospitalized Patients | The Effect of Integrated CAM Treatment in Patients Hospitalized at a Korean Medicine Hospital | Low Back Pain;Neck Pain;Knee Pain;Shoulder Pain;Intervertebral Disc Herniation;Spinal Stenosis | Drug: Herbal medicine;Procedure: Acupuncture;Procedure: Pharmacopuncture;Procedure: Bee venom pharmacopuncture;Procedure: Chuna manipulation | Jaseng Hospital of Korean Medicine | NULL | Recruiting | N/A | N/A | All | 100000 | Korea, Republic of | |
| 73 | EUCTR2011-002917-12-SE (EUCTR) | 06/12/2011 | 27/09/2011 | Does parathyroid hormone enhance healing after spinal fusion? | Does PTH enhance healing after spinal fusion? - PTH spinal stenosis | Decompression and fusion due to spinal stenosis in men and postmenopausal women. In this study we want to examine if Forsteo (teriparatide) improves bone healing (jugded by blinded investigators) and if this improves the function and decreases the pain at 7 weeks and 6 months.;Therapeutic area: Body processes [G] - Bones and nerves physological processes [G11] | Trade Name: Forsteo | Department of Orthopaedics IKE | Department of Orthopaedics IKE | Not Recruiting | Female: yes Male: yes | 100 | Phase 4 | Sweden | ||
| 74 | JPRN-UMIN000006588 | 2011/11/01 | 01/11/2011 | Effect of antiplatelet agent on muscle cramps after surgery of lumbar spinal stenosis in patients with lumbar spinal canal stenosis and peripheral artery disease | Effect of antiplatelet agent on muscle cramps after surgery of lumbar spinal stenosis in patients with lumbar spinal canal stenosis and peripheral artery disease - Effect of antiplatelet agent on muscle cramps after surgery of lumbar spinal stenosis in patients with lumbar spinal canal stenosis and peripheral artery disease | Lumbar spinal canal stenosis | Continuous administration of cilostazol | Juntendo UniversityDepartment of Orthopaedic Surgery | NULL | Recruiting | Not applicable | Not applicable | Male and Female | 30 | Not applicable | Japan |
| 75 | NCT01456377 (ClinicalTrials.gov) | July 2011 | 12/10/2011 | The Effectiveness of Oral Corticosteroids in the Treatment of Lumbar Stenosis | A Prospective Controlled Study Randomized Double Blind Study, Evaluate the Effectiveness of Oral Corticosteroids in the Treatment of Stenosis of Lumbar Canal In Symptomatic Patients | Spinal Stenosis of Lumbar Region | Drug: predinose oral;Drug: placebo group | Federal University of São Paulo | NULL | Recruiting | 50 Years | 75 Years | Both | 60 | N/A | Brazil |
| 76 | NCT01315145 (ClinicalTrials.gov) | March 2011 | 11/3/2011 | MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study | MiDAS III (Mild® Decompression Alternative to Open Surgery): Vertos Mild Patient Evaluation Study | Lumbar Spinal Stenosis | Procedure: Percutaneous Lumbar Decompression;Drug: Epidural Steroid Injection | Vertos Medical, Inc. | NULL | Completed | 50 Years | N/A | All | 138 | N/A | United States |
| 77 | JPRN-UMIN000004825 | 2011/01/01 | 06/01/2011 | A randomized comparative study of Celecoxib and Limaprost alfadex on the patients with lumber spinal stenosis for the effectiveness for symptoms and QOL | A randomized comparative study of Celecoxib and Limaprost alfadex on the patients with lumber spinal stenosis for the effectiveness for symptoms and QOL - A randomized comparative study of medications for patients with lumber spinal stenosis | Lumbar spinal stenosis | 15ug/day Limaprost arfadex for 8 weeks 200mg/day Celecoxib for 8 weeks | University of Tsukuba, Course of life-style related disorders donated by JA Ibaraki Public Welfare Federation | Mito Kyodo Hospital | Complete: follow-up complete | 40years-old | 85years-old | Male and Female | 134 | Phase 3 | Japan |
| 78 | NCT01275547 (ClinicalTrials.gov) | January 2011 | 11/1/2011 | The Analgesic Effect of Combined Treatment With Intranasal S-ketamine and Intranasal Midazolam | The Analgesic Effect of Combined Treatment With Intranasal S-Ketamine and Intranasal Midazolam Compared With Morphine Patient Controlled Analgesia in Spinal Surgery Patients | Analgesia, Patient-controlled;Spinal Stenosis | Drug: s-ketamine & midazolam;Drug: Morphine PCA | University Hospital, Basel, Switzerland | NULL | Completed | 18 Years | N/A | Both | 22 | Phase 2/Phase 3 | Switzerland |
| 79 | JPRN-UMIN000005382 | 2010/12/01 | 05/04/2011 | Intraoperative perineural infiltration of ropivacaine for acute postlaminectomy pain | Intraoperative perineural infiltration of ropivacaine for acute postlaminectomy pain - Intraoperative perineural infiltration of ropivacaine for acute postlaminectomy pain | lumbar spinal stenosis | General anesthesia and NSAIDs. As a contorol,saline 10ml infiltrate per one interspinal segment. Generalanesthesia and NSAIDs. 0.2%ropivacaine 10ml infiltrate per one interspinal segment. General anesthesia and NSAIDs. From catheter in injury part,administration of 0.2%ropivacaine 6ml/h. Duration of administration:2 days after the operation. | Higashi Ohmiya general hospital | NULL | Complete: follow-up complete | 20years-old | 75years-old | Male and Female | 60 | Not selected | Japan |
| 80 | JPRN-UMIN000005959 | 2010/11/04 | 12/07/2011 | Prospective clinical study of the therapeutic effects of prostaglandin in patients with combined lumbar spinal stenosis and arteriosclerosis obliterans showing intermittent claudication | Prospective clinical study of the therapeutic effects of prostaglandin in patients with combined lumbar spinal stenosis and arteriosclerosis obliterans showing intermittent claudication - Clinical study on therapeutic effects of prostaglandin in patients with combined lumbar spinal stenosis and arteriosclerosis obliterans | Patients with combined lumbar spinal stenosis and arteriosclerosis obliterans | Prostaglandin for injection (alprostadil) group: 60 mcg of prostaglandin for injection is intravenously administered once a week or more. This therapy is repeated 10 times or more. Ripple injection (alprostadil Injection) group: 10 mcg of ripple injection is administered intravenously once a week or more. This treatment is repeated 10 times or more. Conventional treatment group | Tokai University HospitalDepartment of Orthopaedic Surgery | NULL | Complete: follow-up complete | 20years-old | Not applicable | Male and Female | 300 | Not selected | Japan |
| 81 | NCT01377623 (ClinicalTrials.gov) | September 2010 | 3/1/2011 | Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion | Pilot Study on the Effect of Dexmedetomidine on Inflammatory Responses in Patients Undergoing Lumbar Spinal Fusion | Spinal Stenosis;Inflammation | Drug: Dexmedetomidine group;Drug: Placebo group | New York University School of Medicine | Hospira, now a wholly owned subsidiary of Pfizer | Terminated | 18 Years | N/A | All | 66 | N/A | United States |
| 82 | NCT01097486 (ClinicalTrials.gov) | June 2010 | 30/3/2010 | Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy | Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation | Cervical Degenerative Disc Disease;Degenerative Spondylolisthesis;Spinal Stenosis | Biological: NeoFuse;Procedure: Allograft | Mesoblast, Ltd. | NULL | Completed | 18 Years | 70 Years | All | 24 | Phase 2 | United States |
| 83 | NCT01106417 (ClinicalTrials.gov) | June 2010 | 16/4/2010 | Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion | Phase 2 Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion With Anterior Cervical Plate Fixation | Cervical Degenerative Disc Disease;Degenerative Spondylolisthesis;Spinal Stenosis | Biological: NeoFuse;Device: MasterGraft Granules | Mesoblast, Ltd. | NULL | Completed | 18 Years | 70 Years | All | 12 | Phase 1/Phase 2 | Australia |
| 84 | NCT01127100 (ClinicalTrials.gov) | May 2010 | 19/5/2010 | Gabapentin Versus Transdermal Fentanyl Matrix for Chronic Neuropathic Pain | Gabapentin Versus Transdermal Fentanyl Matrix (TDF) for Chronic Neuropathic Pain (of Radicular Origin): A Multicenter Randomized, Parallel Group, Rater Blinded, Non-inferiority Trial | Neuropathic Pain;Spinal Stenosis | Drug: transdermal fentanyl matrix, gabapentin | Seoul National University Hospital | Seoul National University Bundang Hospital;Asan Medical Center;Inje University;Chonnam National University Hospital;Chung-Ang University Hosptial, Chung-Ang University College of Medicine;Dankook University | Completed | 20 Years | 80 Years | Both | 108 | Phase 4 | Korea, Republic of |
| 85 | NCT01052324 (ClinicalTrials.gov) | March 2010 | 11/1/2010 | The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation | The Effect Site Concentration of Remifentanil for Conscious Sedation During Awake Nasotracheal Fiberoptic Intubation | Cervical Disc Herniation;Cervical Spinal Stenosis;Cervical Spine Damage | Drug: Remifentanil | Yonsei University | NULL | Completed | 20 Years | 65 Years | Both | 19 | Phase 4 | Korea, Republic of |
| 86 | NCT00996073 (ClinicalTrials.gov) | September 2009 | 9/10/2009 | Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion | A Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With MasterGraft Matrix in Subjects Undergoing Lumbar Interbody Fusion With Instrumentation | Degenerative Disc Disease;Degenerative Spondylolisthesis;Spinal Stenosis | Biological: Lumbar Interbody Fusion with Autograft;Biological: Lumbar Interbody Fusion with NeoFuse | Mesoblast, Ltd. | NULL | Completed | 18 Years | 70 Years | All | 24 | Phase 2 | United States |
| 87 | NCT00995371 (ClinicalTrials.gov) | August 2009 | 14/10/2009 | Study of Epidural Steroid Injection (ESI) Versus Minimally Invasive Lumbar Decompression (Mild®) in Patients With Symptomatic Lumbar Central Canal Stenosis | Comparative Study of Epidural Steroid Injection Versus Mild® (Minimally Invasive Lumbar Decompression) Procedure in Patients Diagnosed With Symptomatic Moderate to Severe Lumbar Central Canal Stenosis | Lumbar Spinal Stenosis | Device: MILD® (Minimally Invasive Lumbar Decompression);Drug: Epidural Steroid Injection | Coastal Orthopedics & Sports Medicine | Vertos Medical, Inc. | Completed | 18 Years | N/A | All | 38 | Phase 4 | United States |
| 88 | NCT00808665 (ClinicalTrials.gov) | June 2009 | 15/12/2008 | Intraoperative Infusion of Precedex to Reduce Length of Stay After Lumbar Spine Fusion | Does Continuous Perioperative Dexmedetomidine Infusion Reduce Time to Discharge in Patients Undergoing Major Lumbar Fusion? A Double-Blind, Placebo-Controlled Study | Spinal Fusion Acquired;Spinal Stenosis;Lesions of Lumbosacral Intervertebral Disc;Spinal Diseases | Drug: Dexmedetomidine;Drug: 0.9% Saline | Vanderbilt University Medical Center | NULL | Completed | 18 Years | 85 Years | All | 68 | Phase 4 | United States |
| 89 | NCT00908375 (ClinicalTrials.gov) | May 2009 | 21/5/2009 | Efficacy of Pregabalin in Patients With Radicular Pain | Efficacy of Pregabalin in Patients With Radicular Pain | Neuropathy; Radicular, Lumbar, Lumbosacral;Failed Back Surgery Syndrome;Spinal Stenosis;Herniated Disc | Drug: Pregabalin;Drug: Sugar Pill | Northwestern University | NULL | Completed | 18 Years | 64 Years | All | 39 | Phase 4 | United States |
| 90 | NCT00810212 (ClinicalTrials.gov) | November 2008 | 17/12/2008 | Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion | A Prospective, Multicenter, Randomized, Open-Label, Controlled Study Evaluating Safety and Preliminary Efficacy of NeoFuse When Combined With Mastergraft Granules in Subjects Undergoing Posterolateral Lumbar Fusion With Instrumentation | Degenerative Disc Disease;Degenerative Spondylolisthesis;Spinal Stenosis | Procedure: PLF with autograft;Biological: PLF with NeoFuse | Mesoblast, Ltd. | NULL | Withdrawn | 18 Years | 70 Years | All | 0 | Phase 1/Phase 2 | United States |
| 91 | NCT00652093 (ClinicalTrials.gov) | March 2008 | 11/3/2008 | Lumbar Stenosis Outcomes Research II | Lumbar Stenosis Outcomes Research II: Opana IR Versus Placebo and Active Control (Darvocet) for the Treatment of Walking Impairment in Lumbar Spinal Stenosis: A Double-Blind Randomized, Cross-Over Trial | Lumbar Spinal Stenosis | Drug: opana then darvocet then placebo;Drug: opana then placebo then darvocet;Drug: placebo then opana then darvocet;Drug: Placebo then darvocet then opana;Drug: Darvocet then opana then placebo;Drug: Darvocet then placebo then opana | University of Rochester | Endo Pharmaceuticals | Terminated | 50 Years | N/A | All | 24 | Phase 4 | United States |
| 92 | NCT00638443 (ClinicalTrials.gov) | March 2008 | 12/3/2008 | Lumbar Stenosis Outcomes Research (LUSTOR) | Lumbar Stenosis Outcomes Research (LUSTOR)- A Randomized, Double-blind, Cross-over Trial of Pregabalin vs. Diphenhydramine in Patients With Lumbar Spinal Stenosis and Neuropathic Low Back Pain | Lumbar Spinal Stenosis | Drug: Pregabalin;Drug: Diphenhydramine | University of Rochester | Pfizer | Completed | 50 Years | N/A | All | 29 | Phase 4 | United States |
| 93 | NCT00549913 (ClinicalTrials.gov) | October 2007 | 24/10/2007 | Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF) | A Dose-escalation Study to Assess the Feasibility and Safety of 3 Different Doses of NeoFuse When Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion With Instrumentation. | Degenerative Disc Disease;Spondylolisthesis;Spinal Stenosis | Biological: NeoFuse;Procedure: posterolateral spinal fusion with instrumentation | Mesoblast, Ltd. | NULL | Completed | 18 Years | N/A | All | 6 | Phase 1/Phase 2 | United States |
| 94 | NCT00370799 (ClinicalTrials.gov) | January 2007 | 30/8/2006 | Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain | A Randomized, Prospective, Double-Blind Controlled Evaluation of the Effectiveness of Caudal Epidural Injections in Lumbar Disc Herniations, Spinal Stenosis, Discogenic Pain, and Post-Lumbar Laminectomy Syndrome | Low Back Pain | Drug: Caudal epidural injection;Drug: Caudal Epidural Injection with generic Celestone;Drug: Caudal Epidural Injection with Celestone;Drug: Caudal Epidural Injection with DepoMedrol | Pain Management Center of Paducah | NULL | Completed | 18 Years | N/A | Both | 240 | Phase 0 | United States |
| 95 | NCT00320619 (ClinicalTrials.gov) | September 2000 | 28/4/2006 | Epsilon-Aminocaproaic Acid to Reduce the Need for Blood Transfusions During and Following Spine Surgery | Aminocaproic Acid and Bleeding in Spinal Surgery | Scoliosis;Kyphosis;Lordosis;Spondylitis;Spinal Stenosis | Drug: Epsilon-Aminocaproic Acid (EACA);Drug: Placebo | National Heart, Lung, and Blood Institute (NHLBI) | NULL | Completed | 18 Years | N/A | Both | 182 | N/A | United States |