79. 家族性高コレステロール血症（ホモ接合体） Homozygous familial hypercholesterolemia Clinical trials / Disease details

臨床試験数 : 145 / 薬物数 : 114 - (DrugBank : 26) / 標的遺伝子数 : 8 - 標的パスウェイ数 : 17

28 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2017-003170-13-AT (EUCTR)	23/07/2019	11/02/2019	Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hyperc ...	An open-label study to evaluate the long-term safety and efficacy of evinacumab in patients with hom ...	Homozygous familial hypercholesterolemia MedDRA version: 21.0;Level: LLT;Classification code 1002060 ...	Product Name: Evinacumab (REGN1500) Product Code: REGN1500 INN or Proposed INN: Evinacumab Other descrip ...	Regeneron Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	121	Phase 3	United States;Greece;Ukraine;Austria;United Kingdom;Italy;France;Czech Republic;Canada;Australia;Sou ...
2	EUCTR2017-003170-13-IT (EUCTR)	18/02/2019	22/01/2021	Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hyperc ...	An open-label study to evaluate the long-term safety and efficacy of evinacumab in patients with hom ...	Homozygous familial hypercholesterolemia MedDRA version: 20.0;Level: LLT;Classification code 1005708 ...	Trade Name: na Product Name: Evinacumab (REGN1500) Product Code: [REGN1500] INN or Proposed INN: Evinacu ...	REGENERON PHARMACEUTICALS, INC.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	100	Phase 3	United States;Czechia;Greece;Ukraine;Austria;United Kingdom;Italy;France;Czech Republic;Canada;Austr ...
3	EUCTR2017-003170-13-GR (EUCTR)	01/02/2019	14/01/2019	Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hyperc ...	An open-label study to evaluate the long-term safety and efficacy of evinacumab in patients with hom ...	Homozygous familial hypercholesterolemia MedDRA version: 21.0;Level: LLT;Classification code 1002060 ...	Product Name: Evinacumab (REGN1500) Product Code: REGN1500 INN or Proposed INN: Evinacumab Other descrip ...	Regeneron Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	121	Phase 3	United States;Czechia;Greece;Ukraine;Austria;United Kingdom;Italy;France;Czech Republic;Canada;Austr ...
4	EUCTR2017-003170-13-CZ (EUCTR)	17/12/2018	11/10/2018	Evaluate the Long-Term Safety and Efficacy of Evinacumab in Patients With Homozygous Familial Hyperc ...	An open-label study to evaluate the long-term safety and efficacy of evinacumab in patients with hom ...	Homozygous familial hypercholesterolemia MedDRA version: 21.0;Level: LLT;Classification code 1002060 ...	Product Name: Evinacumab (REGN1500) Product Code: REGN1500 INN or Proposed INN: Evinacumab Other descrip ...	Regeneron Pharmaceuticals, Inc.	NULL	Not Recruiting			Female: yes Male: yes	121	Phase 3	United States;Greece;Ukraine;Austria;United Kingdom;Italy;France;Czech Republic;Canada;Australia;Sou ...
5	EUCTR2017-002297-39-SI (EUCTR)	25/09/2018	20/06/2018	An Efficacy and Safety Study of Alirocumabin Children and Adolescents with Homozygous Familial Hyper ...	An Open-Label Study to Evaluate the Efficacy and Safety of Alirocumabin Children and Adolescents wit ...	Homozygous Familial Hypercholesterolemia MedDRA version: 20.0;Level: PT;Classification code 10020603 ...	Product Name: Alirocumab Product Code: SAR236553 INN or Proposed INN: Alirocumab Other descriptive name ...	Sanofi-Aventis Recherche & Développement	NULL	Not Recruiting			Female: yes Male: yes	50	Phase 3	United States;Taiwan;Slovenia;Spain;Turkey;Austria;Russian Federation;Italy;France;Mexico;Canada;Arg ...
6	EUCTR2017-002297-39-NO (EUCTR)	19/09/2018	15/05/2018	An Efficacy and Safety Study of Alirocumabin Children and Adolescents with Homozygous Familial Hyper ...	An Open-Label Study to Evaluate the Efficacy and Safety of Alirocumabin Children and Adolescents wit ...	Homozygous Familial Hypercholesterolemia MedDRA version: 20.0;Level: PT;Classification code 10020603 ...	Product Name: Alirocumab Product Code: SAR236553 INN or Proposed INN: Alirocumab Other descriptive name ...	Sanofi-Aventis Recherche & Développement	NULL	Not Recruiting			Female: yes Male: yes	50	Phase 3	Netherlands;United States;Taiwan;Slovenia;Spain;Turkey;Austria;Russian Federation;Italy;France;Mexic ...
7	EUCTR2017-002297-39-BG (EUCTR)	11/09/2018	31/07/2018	An Efficacy and Safety Study of Alirocumabin Children and Adolescents with Homozygous Familial Hyper ...	An Open-Label Study to Evaluate the Efficacy and Safety of Alirocumabin Children and Adolescents wit ...	Homozygous Familial Hypercholesterolemia MedDRA version: 20.0;Level: PT;Classification code 10020603 ...	Product Name: Alirocumab Product Code: SAR236553 INN or Proposed INN: Alirocumab Other descriptive name ...	Sanofi-Aventis Recherche & Développement	NULL	Not Recruiting			Female: yes Male: yes	50	Phase 3	United States;Taiwan;Slovenia;Spain;Turkey;Austria;Russian Federation;Italy;France;Mexico;Canada;Arg ...
8	EUCTR2017-002297-39-AT (EUCTR)	04/09/2018	07/06/2018	An Efficacy and Safety Study of Alirocumabin Children and Adolescents with Homozygous Familial Hyper ...	An Open-Label Study to Evaluate the Efficacy and Safety of Alirocumabin Children and Adolescents wit ...	Homozygous Familial Hypercholesterolemia MedDRA version: 20.0;Level: PT;Classification code 10020603 ...	Product Name: Alirocumab Product Code: SAR236553 INN or Proposed INN: Alirocumab Other descriptive name ...	Sanofi-Aventis Recherche & Développement	NULL	Not Recruiting			Female: yes Male: yes	50	Phase 3	Austria;United States;Taiwan;Slovenia;Spain;Turkey;Russian Federation;Italy;France;Mexico;Canada;Arg ...
9	EUCTR2017-002297-39-DK (EUCTR)	03/09/2018	04/06/2018	An Efficacy and Safety Study of Alirocumabin Children and Adolescents with Homozygous Familial Hyper ...	An Open-Label Study to Evaluate the Efficacy and Safety of Alirocumabin Children and Adolescents wit ...	Homozygous Familial Hypercholesterolemia MedDRA version: 20.0;Level: PT;Classification code 10020603 ...	Trade Name: Praluent Product Name: Alirocumab Product Code: SAR236553 INN or Proposed INN: Alirocumab Ot ...	Sanofi-Aventis Recherche & Développement	NULL	Not Recruiting			Female: yes Male: yes	50	Phase 3	United States;Taiwan;Slovenia;Spain;Turkey;Austria;Russian Federation;Italy;France;Mexico;Canada;Arg ...
10	NCT03510715 (ClinicalTrials.gov)	August 31, 2018	18/4/2018	An Efficacy and Safety Study of Alirocumabin Children and Adolescents With Homozygous Familial Hyper ...	An Open-Label Study to Evaluate the Efficacy and Safety of Alirocumabin Children and Adolescents Wit ...	Hypercholesterolemia	Drug: Alirocumab SAR236553 (REGN727);Drug: Rosuvastatin;Drug: Ezetimibe;Drug: Cholestyramine;Drug: Ni ...	Sanofi	Regeneron Pharmaceuticals	Completed	8 Years	17 Years	All	18	Phase 3	Brazil;Canada;Denmark;Mexico;Netherlands;Russian Federation;Slovenia;Spain;Taiwan;Turkey;Austria;Fra ...

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