86. 肺動脈性肺高血圧症 Pulmonary arterial hypertension Clinical trials / Disease details
臨床試験数 : 1,205 / 薬物数 : 684 - (DrugBank : 124) / 標的遺伝子数 : 100 - 標的パスウェイ数 : 193
Showing 1 to 10 of 126 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05649748 (ClinicalTrials.gov) | February 28, 2023 | 6/12/2022 | A Study to Assess the Safety, Tolerability, and Effectiveness of the Long-Term Use of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Arterial Hypertension (PAH) A Study to Assess the Safety, Tolerability, and Effectiveness of the Long-Term Use of TreprostinilPa ... | An Open-Label Extension Study to Assess the Safety, Tolerability, and Effectiveness of the Long-Term Use of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertension An Open-Label Extension Study to Assess the Safety, Tolerability, and Effectiveness of the Long-Term ... | Pulmonary Arterial Hypertension | Drug: Treprostinil Palmitil;Drug: Placebo | Insmed Incorporated | NULL | Recruiting | 18 Years | N/A | All | 100 | Phase 2/Phase 3 | Japan |
| 2 | NCT05564637 (ClinicalTrials.gov) | February 2023 | 28/9/2022 | A Study of Treprostinil to Treat Interstitial Lung Disease Pulmonary Hypertension | Comprehensive O2 Transfer Analysis From the Lung to Mitochondria of Inhaled Treprostinil in Interstitial Lung Disease Pulmonary Hypertension Comprehensive O2 Transfer Analysis From the Lung to Mitochondria of Inhaled Treprostinilin Interstit ... | Pulmonary Arterial Hypertension;Interstitial Lung Disease;Healthy Adults | Drug: Treprostinil;Diagnostic Test: Right Heart Catheterization (RHC) while exercising;Diagnostic Test: Optional Muscle Biopsy Drug: Treprostinil;Diagnostic Test: Right Heart Catheterization (RHC) while exercising;Diagnostic Te ... | Mayo Clinic | United Therapeutics | Recruiting | 18 Years | N/A | All | 18 | Phase 2 | United States |
| 3 | NCT05147805 (ClinicalTrials.gov) | August 24, 2022 | 24/11/2021 | A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertension A Study to Evaluate the Efficacy, Safety and Pharmacokinetics of TreprostinilPalmitil Inhalation Pow ... | A Phase 2b, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertension A Phase 2b, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy ... | Pulmonary Arterial Hypertension | Drug: Treprostinil Palmitil;Drug: Placebo | Insmed Incorporated | NULL | Recruiting | 18 Years | 75 Years | All | 99 | Phase 2 | United States;Argentina;Australia;Austria;Belgium;Brazil;Denmark;Germany;Italy;Japan;Malaysia;Mexico;Philippines;Serbia;Spain;Switzerland;United Kingdom United States;Argentina;Australia;Austria;Belgium;Brazil;Denmark;Germany;Italy;Japan;Malaysia;Mexico ... |
| 4 | NCT05203510 (ClinicalTrials.gov) | August 10, 2022 | 10/1/2022 | A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Participants With Pulmonary Arterial Hypertension A Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid TreprostinilThera ... | A Phase 4, Prospective, Multicenter, Single-Arm Study of a Mean Pulmonary Artery Pressure-Targeted Approach With Early and Rapid Treprostinil Therapy to Reverse Right Ventricular Remodeling in Patients With Pulmonary Arterial Hypertension: ARTISAN (Afterload Reduction To Improve Right Ventricular Structure And FuNction) A Phase 4, Prospective, Multicenter, Single-Arm Study of a Mean Pulmonary Artery Pressure-Targeted A ... | Pulmonary Arterial Hypertension | Drug: Parenteral Treprostinil;Drug: Oral Treprostinil | United Therapeutics | Lung Biotechnology PBC | Recruiting | 18 Years | N/A | All | 50 | Phase 4 | United States |
| 5 | JPRN-jRCT2071220033 | 02/08/2022 | 02/08/2022 | A Randomized, Double-Blind, Placebo-Controlled Study of Treprostinil Palmitil Inhalation Powder in Participants with Pulmonary Arterial Hypertension A Randomized, Double-Blind, Placebo-Controlled Study of TreprostinilPalmitil Inhalation Powder in Pa ... | A Phase 2b, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Treprostinil Palmitil Inhalation Powder in Participants with Pulmonary Arterial Hypertension A Phase 2b, Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Efficacy ... | Pulmonary Arterial Hypertension | Experimental: Treprostinil Palmitil Inhalational Powder Participants will be administered TPIP once per day at a starting dose of 80 micrograms. Participants will be titrated to the highest tolerated dose for each individual participant of between 80 micrograms and 640 micrograms during the initial 3 weeks of treatment. The overall treatment period will be 16 weeks. Placebo Comparator: Placebo Participants will be administered a placebo matching TPIP once per day for 16 weeks. Experimental: TreprostinilPalmitil Inhalational Powder Participants will be administered TPIP once pe ... | F Ismat | NULL | Recruiting | > 18age old | < 75age old | Both | 99 | Phase 2 | United States;Argentina;Australia;Mexico;Phillipines;Japan |
| 6 | NCT04791514 (ClinicalTrials.gov) | March 29, 2022 | 8/3/2021 | A Study of Treprostinil Palmitil Inhalation Powder (TPIP) In Pulmonary Arterial Hypertension (PAH) | An Open-Label Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of Treprostinil Palmitil Inhalation Powder in Participants With Pulmonary Arterial Hypertension An Open-Label Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of TreprostinilPalm ... | Pulmonary Arterial Hypertension | Drug: Treprostinil Palmitil | Insmed Incorporated | NULL | Terminated | 18 Years | N/A | All | 1 | Phase 2 | United States |
| 7 | EUCTR2021-004002-21-AT (EUCTR) | 26/11/2021 | 06/09/2021 | A non-randomized, single-center, open, two-period study with paired design to compare measured steady-state treprostinil concentrations in human plasma under treatment with a 10 mg/ml treprostinil formulation and following a switch to a 20 mg/ml treprostinil formulation in patients with pulmonary arterial hypertension (PAH) A non-randomized, single-center, open, two-period study with paired design to compare measured stead ... | A single center, open-label, two-period, non-randomized, paired-design study to compare steady-state plasma levels following switch from a 10 mg/ml treprostinil formulation to a 20 mg/ml treprostinil formulation in patients with pulmonary arterial hypertension (PAH) A single center, open-label, two-period, non-randomized, paired-design study to compare steady-state ... | pulmonary arterial hypertension MedDRA version: 21.1;Level: PT;Classification code 10064911;Term: Pulmonary arterial hypertension;System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disorders;Therapeutic area: Diseases [C] - Cardiovascular Diseases [C14] pulmonary arterial hypertension MedDRA version: 21.1;Level: PT;Classification code 10064911;Term: Pu ... | Product Name: 20 mg/ml Treprostinil INN or Proposed INN: treprostinil sodium Other descriptive name: TREPROSTINIL SODIUM Trade Name: Trisuva(r) Product Name: Trisuva(r) INN or Proposed INN: treprostinil sodium Other descriptive name: TREPROSTINIL SODIUM Product Name: 20 mg/ml Treprostinil INN or Proposed INN: treprostinilsodium Other descriptive name: TR ... | AOP Orphan Pharmaceuticals GmbH | NULL | Not Recruiting | Female: yes Male: yes | 16 | Phase 2 | Austria | ||
| 8 | NCT03833323 (ClinicalTrials.gov) | August 1, 2020 | 5/2/2019 | Implantable System for Remodulin Post-Approval Study | Implantable System for Remodulin Post-Approval Study | Pulmonary Arterial Hypertension | Combination Product: Implantable System for Remodulin (treprostinil) | Medtronic Cardiac Rhythm and Heart Failure | United Therapeutics | Withdrawn | 22 Years | N/A | All | 0 | NULL | |
| 9 | NCT04309838 (ClinicalTrials.gov) | March 2020 | 20/2/2020 | Observation Study With Implantable Medication Pump for Intravenous Treprostinil Therapy in Patients With Pulmonary Arterial Hypertension Observation Study With Implantable Medication Pump for Intravenous TreprostinilTherapy in Patients W ... | LENUS Pro® Study (LPS-II) - Observation Study With Implantable Medication Pump for Intravenous REMODULIN® (Treprostinil) Therapy in Patients With Pulmonary Arterial Hypertension LENUS Pro® Study (LPS-II) - Observation Study With Implantable Medication Pump for Intravenous REMOD ... | Pulmonary Arterial Hypertension;PAH | Combination Product: Treprostinil via implanted pump | University Medicine Greifswald | OMT GmbH & Co. KG | Not yet recruiting | 18 Years | N/A | All | 30 | Germany | |
| 10 | NCT03884465 (ClinicalTrials.gov) | November 11, 2019 | 4/3/2019 | Hemodynamic Evaluation of Dose-response and Safety of Dry Powder Inhalation of Treprostinil | A Two Part, Phase 2 Open-label, Multi-Centre, Dose Escalation Hemodynamic Study to Evaluate Dose-Response and Safety of Inhaled LIQ861 (Treprostinil) in Pulmonary Arterial Hypertension (WHO Group 1) Subjects A Two Part, Phase 2 Open-label, Multi-Centre, Dose Escalation Hemodynamic Study to Evaluate Dose-Res ... | Pulmonary Arterial Hypertension | Drug: Inhaled dry powder treprostinil (LIQ861) | Liquidia Technologies, Inc. | FGK Clinical Research GmbH | Recruiting | 18 Years | N/A | All | 32 | Phase 2 | France;Germany |