88. 慢性血栓塞栓性肺高血圧症 Chronic thromboembolic pulmonary hypertension Clinical trials / Disease details

臨床試験数 : 157 / 薬物数 : 107 - (DrugBank : 22) / 標的遺伝子数 : 14 - 標的パスウェイ数 : 54

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05140525 (ClinicalTrials.gov)	June 1, 2023	28/10/2021	Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodyna ...	Effects of Combination Medical Therapy Followed by Balloon Pulmonary Angioplasty on Right Ventricula ...	CTEPH	Drug: Macitentan Tablets;Drug: Riociguat;Device: balloon pulmonary angioplasty	Dr Sudarshan Rajagopal	Actelion	Not yet recruiting	18 Years	N/A	All	15	Phase 3	United States
2	NCT05179356 (ClinicalTrials.gov)	January 1, 2023	16/12/2021	Dapagliflozin in Pulmonary Arterial Hypertension	Effects of DAPAgliflozin on Cardiopulmonary Exercise Capacity and Hemodynamics in Pulmonary Arterial ...	Pulmonary Arterial Hypertension;Chronic Thromboembolic Pulmonary Hypertension	Drug: Dapagliflozin 10 MG [Farxiga];Drug: Placebo	Mads Ersbøll	NULL	Not yet recruiting	18 Years	N/A	All	52	Phase 2	NULL
3	EUCTR2019-004131-24-PT (EUCTR)	16/12/2022	25/08/2022	A Phase 3 study to evaluate whether macitentan 75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	Russian Federation;Singapore;United States;Czechia;Thailand;Portugal;Saudi Arabia;Austria;China;Kore ...
4	NCT05340023 (ClinicalTrials.gov)	November 9, 2022	17/11/2021	Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension	Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension: PR ...	Chronic Thromboembolic Pulmonary Hypertension	Biological: blood sample	Centre Hospitalier Universitaire de Saint Etienne	NULL	Recruiting	18 Years	N/A	All	120		France
5	EUCTR2021-006787-25-DK (EUCTR)	06/07/2022	22/12/2021	The effects of dapagliflozin in patients with elevated blood pressure in the lungs	Effects of DAPAgliflozin on cardiopulmonary exercise capacity and hemodynamics in Pulmonary Arterial ...	Pulmonary arterial hypertensionChronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Le ...	Trade Name: Forxiga (dapagliflozin) Product Name: Forxiga INN or Proposed INN: Dapagliflozin	Rigshospitalet The Heart Center	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	52	Phase 2	Denmark
6	JPRN-jRCT2051220042	07/06/2022	09/06/2022	Clinical trial of Nitric Oxide inhalation therapy in patients with severe PH	A Single-Center, Randomised, Controlled Trial of the Efficacy and Safety of Inhaled Nitric Oxide the ...	Pulmonary arterial hypertension (PAH), and Chronic thromboembolic pulmonary hypertension(CTEPH) PH, ...	Study drug: Nitric Oxide(INOflo for inhalation 800ppm) Start inhalation at a concentration of 20 ppm, ...	Ogo Takeshi	NULL	Pending	>= 18age old	Not applicable	Both	30	Phase 2	Japan
7	NCT04954742 (ClinicalTrials.gov)	April 13, 2022	29/6/2021	Effects of Riociguat on RIght VEntricular Size and Function in PAH and CTEPH	An Open-label, Prospective, Single Centre Study of the Effects of Riociguat on RIght VEntricular Siz ...	Primary Pulmonary Arterial Hypertension;Chronic Thromboembolic Pulmonary Hypertension	Drug: Riociguat	Heidelberg University	Merck Sharp & Dohme Corp.	Recruiting	18 Years	N/A	All	30	Phase 4	Germany
8	NCT05133713 (ClinicalTrials.gov)	April 1, 2022	1/11/2021	Ventilation and Perfusion Scan in Pulmonary Embolism Following Catheter Directed Thrombectomy Versus ...	Ventilation and Perfusion Imaging in Acute Pulmonary Embolism Following Catheter Directed Aspiration ...	Pulmonary Embolism;Pulmonary Hypertension;Chronic Thromboembolic Pulmonary Hypertension	Device: Catheter directed therapy;Drug: Systemic anticoagulation	University of Arizona	Inari Medical	Recruiting	18 Years	N/A	All	50		United States
9	ChiCTR2100052570	2021-08-01	2021-10-31	A randomized controlled study of the effectiveness of percutaneous pulmonary thrombotic tissue aspir ...	A randomized controlled study of the effectiveness of percutaneous pulmonary thrombotic tissue aspir ...	Chronic Thromboembolic Pulmonary Hypertension	Control group:Traditional simple BPAprocedure;Experimental group:Traditional simple BPA+ thrombotic ...	Fuwai Hospital, Chinese Academy of Medical Sciences	NULL	Recruiting	18	80	Both	Control group:20;Experimental group:20;		China
10	JPRN-jRCT2051200150	12/07/2021	11/03/2021	A study to evaluate efficacy and safety of macitentan 75 mg in inoperable or persistent/recurrent ch ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension	Macitentan Participant will receive macitentanat a dose of 10 milligram (mg) once daily (OD) for 4 we ...	Nakano Masayoshi	NULL	Recruiting	>= 18age old	<= 80age old	Both	144	Phase 3	USA;Germany;Hungary;South Korea;Japan

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