88. 慢性血栓塞栓性肺高血圧症 Chronic thromboembolic pulmonary hypertension Clinical trials / Disease details

臨床試験数 : 157 / 薬物数 : 107 - (DrugBank : 22) / 標的遺伝子数 : 14 - 標的パスウェイ数 : 54

34 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05140525 (ClinicalTrials.gov)	June 1, 2023	28/10/2021	Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodyna ...	Effects of Combination Medical Therapy Followed by Balloon Pulmonary Angioplasty on Right Ventricula ...	CTEPH	Drug: Macitentan Tablets;Drug: Riociguat;Device: balloon pulmonary angioplasty	Dr Sudarshan Rajagopal	Actelion	Not yet recruiting	18 Years	N/A	All	15	Phase 3	United States
2	EUCTR2019-004131-24-PT (EUCTR)	16/12/2022	25/08/2022	A Phase 3 study to evaluate whether macitentan75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	Russian Federation;Singapore;United States;Czechia;Thailand;Portugal;Saudi Arabia;Austria;China;Kore ...
3	JPRN-jRCT2051200150	12/07/2021	11/03/2021	A study to evaluate efficacy and safety of macitentan75 mg in inoperable or persistent/recurrent chr ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension	Macitentan Participant will receive macitentanat a dose of 10 milligram (mg) once daily (OD) for 4 we ...	Nakano Masayoshi	NULL	Recruiting	>= 18age old	<= 80age old	Both	144	Phase 3	USA;Germany;Hungary;South Korea;Japan
4	EUCTR2017-003934-10-PL (EUCTR)	23/06/2021	26/07/2019	A clinical study to investigate the long term safety of the drug macitentanin patients with pulmonar ...	mUlticenter, single-arM, open-laBel, long-teRm safety study with macitEntanin patients with puLmonar ...	Pulmonary arterial hypertension (PAH)Chronic thromboembolic pulmonary hypertension (CTEPH) MedDRA ve ...	Trade Name: Opsumit Product Name: Macitentan Product Code: ACT-064992 INN or Proposed INN: MACITENTAN	Actelion Pharmaceuticals Ltd	NULL	Not Recruiting			Female: yes Male: yes	176	Phase 3	France;Belarus;Belgium;Poland;Ukraine;Turkey;Russian Federation;Germany
5	NCT04780932 (ClinicalTrials.gov)	June 14, 2021	15/2/2021	Initial Dual Oral Combination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Ball ...	Initial Dual Oral coMbination Therapy Versus Standard-of-care Initial Oral Monotherapy Prior to Ball ...	Thromboembolic Pulmonary Hypertension;Chronic Disease;Inoperable Disease	Drug: Macitentan 10mg;Drug: Placebo	Assistance Publique - Hôpitaux de Paris	Janssen, LP	Recruiting	18 Years	80 Years	All	96	Phase 2/Phase 3	France
6	EUCTR2019-004131-24-GB (EUCTR)	23/11/2020	26/05/2020	A Phase 3 study to evaluate whether macitentan75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	United States;United Arab Emirates;Serbia;Taiwan;Saudi Arabia;Slovakia;Spain;Ukraine;Israel;Russian ...
7	EUCTR2019-004131-24-LT (EUCTR)	10/11/2020	22/09/2020	A Phase 3 study to evaluate whether macitentan75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	Serbia;United States;Saudi Arabia;Taiwan;Slovakia;Spain;Ukraine;Russian Federation;Israel;Colombia;I ...
8	EUCTR2019-004131-24-DE (EUCTR)	10/08/2020	26/05/2020	A Phase 3 study to evaluate whether macitentan75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	Serbia;United States;Saudi Arabia;Taiwan;Slovakia;Spain;Ukraine;Russian Federation;Israel;Colombia;I ...
9	EUCTR2019-004131-24-HU (EUCTR)	27/07/2020	28/05/2020	A Phase 3 study to evaluate whether macitentan75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	Serbia;United States;United Arab Emirates;Saudi Arabia;Taiwan;Slovakia;Spain;Ukraine;Russian Federat ...
10	NCT04271475 (ClinicalTrials.gov)	July 7, 2020	13/2/2020	A Study to Evaluate Efficacy and Safety of Macitentan75 mg in Inoperable or Persistent/Recurrent Chr ...	A Prospective, Randomized, Double-blind, Multicenter, Placebo-controlled, Parallel Group, Adaptive P ...	Chronic Thromboembolic Pulmonary Hypertension	Drug: Macitentan;Drug: Placebo	Actelion	NULL	Recruiting	18 Years	80 Years	All	230	Phase 3	Portugal;United States;Argentina;Australia;Austria;Bulgaria;Canada;China;Colombia;Czechia;Denmark;Fr ...

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