Effects of the activation of PPARs in the orphan hepatic disease primary biliary cirrhosis
Effects of the activation of peroxisome proliferator-activated receptors in patients with primary biliary cirrhosis - Effects of the activation of PPARs in patients with PBC Effects of the activation of peroxisome proliferator-activated receptors in patients with primary bi ...
Up to 67% of PBC patients have an incomplete biochemical response to UDCA and remain at increased risk for progression to cirrhosis and liver-related death. In this study we will prospectively examine the therapeutic effects of bezafibrate (a pan-agonist activating PPARalpha/delta/gamma) in patients with early-stage PBC with a specific focus on improvement of liver functions, inflammation, lipid profile, oxidative status and endothelial function.;Therapeutic area: Diseases [C] - Digestive System Diseases [C06] Up to 67% of PBC patients have an incomplete biochemical response to UDCA and remain at increased ri ...