97. 潰瘍性大腸炎 Ulcerative colitis Clinical trials / Disease details


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35 trials found
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1NCT05202990
(ClinicalTrials.gov)
March 202310/1/2022Oral Fecal Microbiota Transplantation in Pediatric Ulcerative ColitisPilot Study of a New Technique of Oral Fecal Transplantation Using Frozen Stool Capsules for the Maintenance Treatment of Pediatric Ulcerative Colitis.Pediatric Ulcerative Colitis in RemissionDrug: Fecal Microbiota Transplantation by Stool capsules;Drug: Fecal Microbiota Transplantation by Intra-rectal enemasAssistance Publique - Hôpitaux de ParisMRSU 938 - Research Center of Saint AntoineNot yet recruiting8 Years17 YearsAll26Phase 2France
2NCT05739864
(ClinicalTrials.gov)
February 13, 202313/2/2023Superdonor FMT in Patients With Ulcerative ColitisEvaluation of the Efficacy of Superdonor Fecal Microbiota Transplantation in Patients With Mild-to-moderate Ulcerative Colitis: a Double-blind Randomized Controlled TrialActive Ulcerative ColitisBiological: FMT;Other: Placebo FMTFondazione Policlinico Universitario Agostino Gemelli IRCCSNULLRecruiting18 Years75 YearsAll42Phase 1/Phase 2Italy
3NCT04968951
(ClinicalTrials.gov)
November 10, 20219/7/2021Refined Fecal Microbiota Transplantation (FMT) for Ulcerative Colitis (UC)REFOCUS: Refined Fecal Microbiota Transplantation (FMT) Delivered by Oral Capsules for Induction of Remission in Mild to Moderate Ulcerative Colitis - a Phase I StudyUlcerative Colitis;FMT;Fecal Microbiota TransplantDrug: Metronidazole;Drug: Placebo;Drug: Vancomycin;Biological: Fecal Microbiota TransplantationAri M GrinspanNULLRecruiting18 Years75 YearsAll20Early Phase 1United States
4NCT05030064
(ClinicalTrials.gov)
September 10, 20219/8/2021Clinical Study on the Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis With DepressionClinical Study on the Efficacy and Safety of Fecal Microbiota Transplantation in the Treatment of Ulcerative Colitis With DepressionUlcerative ColitisDrug: Intestinal flora capsule;Procedure: placebo capsuleThird Military Medical UniversityNULLRecruiting18 Years65 YearsAll54N/AChina
5NCT04373473
(ClinicalTrials.gov)
September 14, 202028/4/2020Evaluation the Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Administered Orally for Prevention of Relapse or Intestinal Inflammation in Adults With Ulcerative ColitisA Phase 2a, Randomized, Double-blinded, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation (PRIM-DJ2727) Administered Orally in Combination With Standard of Care Therapy for Prevention of Relapse or Intestinal Inflammation in Adults With Ulcerative ColitisAdults With Ulcerative ColitisDrug: PRIM-DJ2727;Drug: PlacebosThe University of Texas Health Science Center, HoustonNULLRecruiting18 YearsN/AAll58Phase 2United States
6JPRN-jRCTs031200103
01/09/202001/09/2020Alginate combined fecal microbiota transplantation for ulcerative colitisSingle center randomized study: Alginate combined fecal microbiota transplantation for ulcerative colitis Ulcerative colitis
Ulcerative colitis
A-FMT plus algin acid therapy arm
Patients are performed Colonoscopy before participating in this clinical research and make sure the patients is eligible. Patient undergoes FMT two days after AFM therapy. Approximately 150 g to 200 g of fresh stool provided in advance from a donor is dissolved in 500 ml of physiological saline, and the treated stool that has been processed to remove excess residues and the like through a filter is stored frozen at minus 80 degree celsius. The diluted and filtered fecal suspension with dextrin added is transferred into the patients colon from cecum to rectum during total colonoscopy. As usual examinations, the patient undergoes biopsy of inflammatory site. For the next 8weeks, patients take algin acid two times a day every single day.

A-FMT plus placebo arm
Patients are performed Colonoscopy before participating in this clinical research and make sure the patients is eligible. Patient undergoes FMT two days after AFM therapy. Approximately 150 g to 200 g of fresh stool provided in advance from a donor is dissolved in 500 ml of physiological saline, and the treated stool that has been processed to remove excess residues and the like through a filter is stored frozen at minus 80 degree celsius. The diluted and filtered fecal suspension with dextrin added is transferred into the patients colon from cecum to rectum during total colonoscopy. As usual examinations, the patient undergoes biopsy of inflammatory site. For the next 8weeks, patients take Placebo two times a day every single day.
Ishikawa DaiNULLRecruiting>= 20age oldNot applicableBoth60N/AJapan
7NCT05538026
(ClinicalTrials.gov)
September 1, 20209/9/2022Effectiveness of Fecal Microbiota Transplantation as add-on Therapy in Mild-to-moderate Ulcerative ColitisEfficacy and Safety of Fecal Microbiota Transplantation as add-on Therapy in Patients With Mild-To-Moderate Ulcerative Colitis: A Randomized, Clinical TrialUlcerative Colitis Chronic Mild;Inflammatory Bowel DiseasesDrug: Mesalazine;Biological: Fecal transplantationBogomolets National Medical UniversityUkrainian Research and Practical Centre of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of UkraineCompleted18 Years60 YearsAll53N/AUkraine
8NCT04521205
(ClinicalTrials.gov)
September 202018/8/2020A Multicenter Clinical Trial: Efficacy, Safety of Fecal Microbiota Transplantation for Inflammatory Bowel DiseaseA Multicenter Clinical Trial: Efficacy, Safety of Fecal Microbiota Transplantation for Inflammatory Bowel DiseaseInflammatory Bowel Disease, Ulcerative Colitis TypeDrug: fecal microbiota capsuleZhongshan Hospital Xiamen UniversityNULLRecruiting18 Years65 YearsAll200Phase 1China
9NCT04202211
(ClinicalTrials.gov)
February 202013/12/2019FMT for Remission of Active Ulcerative Colitis in AdultsA Randomized Double-blind, Placebo-controlled Trial of Lyophilized Fecal Microbiota Transplantation for the Induction of Remission in Adults With Active Ulcerative ColitisUlcerative Colitis;Inflammatory Bowel DiseasesBiological: FMT oral;Biological: FMT enema;Other: Placebo oral;Other: Placebo enemaUniversity of British ColumbiaCrohn's and Colitis Canada;Vancouver Island Health AuthorityNot yet recruiting18 YearsN/AAll145Phase 2Canada
10NCT03998488
(ClinicalTrials.gov)
January 31, 202024/6/2019Examining the Efficacy of Fecal Microbiota Transplantation (FMT) and Dietary Fiber in Patients With Ulcerative ColitisA Randomized, Placebo-controlled Clinical Trial Examining the Efficacy of Fecal Microbiota Transplantation (FMT) and Subsequent Dietary Fiber in Patients With Moderate Ulcerative ColitisUlcerative Colitis;Inflammatory Bowel DiseasesDrug: Fecal Microbiota Transplantation;Dietary Supplement: Psyllium Husk PowderWeill Medical College of Cornell UniversityCrohn's and Colitis FoundationRecruiting18 Years89 YearsAll135Phase 2United States
11NCT03716388
(ClinicalTrials.gov)
December 1, 201821/10/2018Fecal Microbiota Therapy Vs 5-aminosalicylates for Induction of Remission in Newly Diagnosed Mild-moderately Active UCFecal Microbiota Therapy Vs 5-aminosalicylates for Induction of Remission in Newly Diagnosed Mild-moderately Active UC : a Pilot StudyUlcerative Colitis Chronic Mild;Ulcerative Colitis Chronic ModerateBiological: Fecal Microbiota Transplantation;Drug: Mesalamine Granules;Other: Placebo infusion;Other: Placebo granulesDayanand Medical College and HospitalColitis & Crohn's Foundation (India)Recruiting18 Years75 YearsAll20Phase 3India
12NCT03483246
(ClinicalTrials.gov)
September 17, 201826/2/2018Impact of Fecal Microbiota Transplantation in Ulcerative ColitisImpact of Fecal Microbiota Transplantation in Ulcerative Colitis: a Randomized, Sham Controlled TrialUlcerative ColitisDrug: Fecal Microbiota Transplantation (FMT);Drug: Sham-transplantation PlaceboAssistance Publique - Hôpitaux de ParisCRB-HUEP;Institut National de la Santé Et de la Recherche Médicale, FranceRecruiting18 Years74 YearsAll150Phase 3France
13EUCTR2017-004967-11-FR
(EUCTR)
26/06/201806/04/2018Prospective multicenter randomized controlled double-blind label study of the prophylaxis of recurrent pouchitis after fecal microbiota transplant in UC with ileo-anal anastomosis.Poca - Poca Patients operated with an IPAA for Ulcerative Colitis with active recurrent pouchitis, who respond after 4 weeks of an antibiotherapy, will be randomized
MedDRA version: 20.1;Level: LLT;Classification code 10000638;Term: Active ileal inflammation;System Organ Class: 100000004856;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: suspension de microbiote fécal
Product Code: PRD5973697
CHU NantesNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
42Phase 3France
14NCT03378921
(ClinicalTrials.gov)
February 27, 201811/12/2017Fecal Microbiota Transplantation in the Treatment of PouchitisDouble-blinded Randomized Placebo Controlled Study: Fecal Microbiota Transplantation in the Treatment of Chronic PouchitisPouchitis;Ulcerative ColitisBiological: Fecal microbiota transplantation;Biological: PlaceboHelsinki University Central HospitalNULLCompleted18 Years75 YearsAll26Phase 2Finland
15ChiCTR2100043797
2018-01-012021-02-28The efficacy and mechanism of fecal microbiota transplantation in the treatment of patients with ulcerative colitisThe efficacy and mechanism of fecal microbiota transplantation in the treatment of patients with ulcerative colitis Ulcerative colitisCase series:Single or multiple FMT were performed via the working channel of the colonoscope or transendoscopic enteral tubing in 2 months. All patients were given concomitant oral mesalamine (4g/d) and patients who were taking corticosteroid did a mandatory taper of 2.5 mg per week until it was withdrawn.;Department of Gastroenterology, Jinan Central HospitalNULLCompleted2181BothCase series:28;N/AChina
16NCT03006809
(ClinicalTrials.gov)
March 2, 201721/12/2016Optimal Fecal Microbiota Transplant Dosing for Mild to Moderate Ulcerative ColitisOptimal Fecal Microbiota Transplant Dosing for Mild to Moderate Ulcerative ColitisUlcerative ColitisBiological: Fecal Microbiota Transplantation (FMT), OpenBiome;Other: pretreatment antibioticsNajwa ElnachefNULLCompleted18 Years64 YearsAll30Phase 1United States
17NCT02998112
(ClinicalTrials.gov)
December 201613/12/2016Fecal Microbiota Transplantation for Ulcerative Colitis Through Colonic Transendoscopic Enteral TubingUlcerative ColitisDrug: fecal microbiota transplantation;Drug: SalineThe Second Hospital of Nanjing Medical UniversityFourth Military Medical University;First Hospital of Guangzhou;Daping Hospital and the Research Institute of Surgery of the Third Military Medical University;Zhongshan Hospital Xiamen UniversityRecruiting18 Years65 YearsBoth188Phase 4China
18NCT02516384
(ClinicalTrials.gov)
October 1, 201629/7/2015Fecal Microbiota Transplantation (FMT) in the Management of Ulcerative Colitis (UC)Fecal Microbiota Transplantation (FMT) in the Management of Ulcerative Colitis (UC)Ulcerative ColitisBiological: Fecal Microbiota TransplantationWeill Medical College of Cornell UniversityNULLCompleted18 YearsN/AAll20Phase 1United States
19JPRN-UMIN000026485
2016/08/0110/03/2017Research on the Efficacy of Fecal Microbiota Transplantation and Microbiota in Japanese Children with Ulcerative Colitis.Research on the Efficacy of Fecal Microbiota Transplantation and Microbiota in Japanese Children with Ulcerative Colitis. - Research on the Efficacy of FMT to the Children with UC ulcerative colitisFecal Microbiota Transplantation(on Day1, 2 and 3, week 2, 3 and 5) after antibiotic pretreatment using amoxicillin 40mg/kg/day, fosfomycin 100mg/kg/day and metronidazole 16mg/kg/day.National Center for Child Health and Development10Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan. Yakult Central Institute, Tokyo, JapanRecruiting2years-old18years-oldMale and Female12Not selectedJapan
20NCT02636517
(ClinicalTrials.gov)
December 201516/12/2015Fecal Microbiome TransplantFecal Microbiome Transplant in Pediatric C. DifficileClostridium Difficile;Inflammatory Bowel Disease;Crohn's Disease;Ulcerative ColitisBiological: Fecal Microbiota TransplantChildren's Hospital of PhiladelphiaNULLActive, not recruiting3 Years21 YearsAll250N/AUnited States
21NCT02390726
(ClinicalTrials.gov)
December 201519/2/2015Fecal Microbiota Transplant in the Treatment of Ulcerative ColitisFecal Microbiota Transplant in the Treatment of Ulcerative ColitisUlcerative Colitis, Active ModerateBiological: Fecal Microbiota Transplant;Biological: PlaceboUniversity of VermontNULLUnknown status18 Years75 YearsAll20Early Phase 1United States
22NCT02330653
(ClinicalTrials.gov)
November 201529/12/2014Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis and Pediatric Active Crohn's ColitisA Phase I/II, Double Blinded, Placebo Controlled, Single-center Study of Fecal Microbiota Transplant (FMT) for the Treatment of Active Pediatric Ulcerative Colitis and Pediatric Active Crohn's ColitisInflammatory Bowel Diseases;Ulcerative Colitis;Crohn DiseaseBiological: Fecal Microbiota Transplant (FMT);Biological: PlaceboStacy A. KahnNULLCompleted5 Years30 YearsAll15Phase 1/Phase 2United States
23NCT02487238
(ClinicalTrials.gov)
November 201525/6/2015Pediatric FEcal Microbiota Transplant for Ulcerative ColitisA Single-Blind, Randomized, Placebo-Controlled Trial of Human Fecal Microbiota Transplantation for the Therapy of Pediatric Ulcerative Colitis and Inflammatory Bowel Disease UnclassifiedInflammatory Bowel Disease;Ulcerative ColitisBiological: Fecal Microbiota Enema;Biological: Normal Saline EnemaMcMaster Children's HospitalLondon Health Sciences Centre;St. Justine's HospitalCompleted3 Years17 YearsAll35Phase 1Canada
24JPRN-UMIN000018642
2015/08/1211/08/2015A trial of fecal microbiota transplantation and / or antibiotics therapy for ulcerative colitisA trial of fecal microbiota transplantation and / or antibiotics therapy for ulcerative colitis - A trial of fecal microbiota transplantation and / or antibiotics therapy for ulcerative colitis ulcerative colitisAntibiotics therapy:Taking three kinds of antibiotics (Amoxicillin, fosmycin, metronidazole) for two weeks.
FMT:Administration of the fecal material from healthy donors to patients.
Juntendo university school of medicine Department of gastroenterologyNULLComplete: follow-up complete6years-oldNot applicableMale and Female50Not selectedJapan
25NCT02575040
(ClinicalTrials.gov)
May 20156/10/2015Efficacy of Fecal Microbiota Transplantation for Inflammatory Bowel DiseaseEfficacy of Fecal Microbiota Transplantation for Refractory Inflammatory Bowel DiseaseUlcerative Colitis;Crohn Disease;Constipation (Excl Faecal Impaction)Biological: Fecal microbiota transplantationGulhane Military Medical AcademyNULLRecruiting18 YearsN/ABoth60Phase 3Turkey
26NCT02435160
(ClinicalTrials.gov)
May 201523/4/2015The Study of Efficacy and Mechanism in Fecal Microbiota Transplantation in the Treatment of Ulcerative ColitisUlcerative Colitis;Fecal Microbiota TransplantationBiological: Fecal Microbiota TransplantationJun LiuNULLNot yet recruiting25 Years60 YearsMale20Phase 2/Phase 3NULL
27NCT02335281
(ClinicalTrials.gov)
January 20157/1/2015Standardized Fecal Microbiota Transplantation for Inflammatory Bowel DiseaseEfficacy, Durability and Safety of Standardized Fecal Microbiota Transplantation for Severe Inflammatory Bowel DiseaseInflammatory Bowel Disease;Ulcerative Colitis;Crohn's DiseaseProcedure: FMT;Drug: MesalazineYanling WeiNULLRecruiting16 Years70 YearsBoth40Phase 2China
28NCT02227342
(ClinicalTrials.gov)
July 201422/7/2014Fecal Microbiota Transplantation (FMT) in the Management of Active Ulcerative ColitisA Prospective, Single Center, Open Label Trial of Fecal Microbiota Transplantation (FMT) in the Management of Active Ulcerative ColitisUlcerative ColitisBiological: Fecal Microbiota TransplantUniversity of AlbertaNULLCompleted18 Years65 YearsBoth3Phase 1/Phase 2Canada
29NCT02049502
(ClinicalTrials.gov)
July 201427/1/2014FMT in Ulcerative Colitis-Associated PouchitisThe Use of Fecal Microbiota Transplantation in Patients With Ulcerative Colitis-associated PouchitisUlcerative Colitis Associated PouchitisBiological: biologically active human fecal microbiota;Procedure: sigmoidoscopyVirginia O. ShafferNULLCompleted18 Years65 YearsAll8Phase 2United States
30JPRN-UMIN000014152
2014/06/0404/06/2014A trial of a combination therapy of fecal microbiota transplantation and antibiotics or simple fecal microbiota therapy for ulcerative colitisA trial of a combination therapy of fecal microbiota transplantation and antibiotics or simple fecal microbiota therapy for ulcerative colitis - A trial of a combination therapy of FMT and antibiotics or FMT for ulcerative colitis ulcerative colitisAdministration of the fecal material from healthy donors to patients after taking three kinds of antibiotics (Amoxicillin, fosmycin, metronidazole) for two weeksJuntendo university school of medicine Department of gastroenterologyNULLComplete: follow-up complete20years-oldNot applicableMale and Female30Not selectedJapan
31NCT02108821
(ClinicalTrials.gov)
March 201421/3/2014Fecal Microbiota Transplantation in Pediatric PatientsA Study of Fecal Microbiota Transplantation in Pediatric Patients With Relapsed Inflammatory Bowel Disease.Inflammatory Bowel Diseases (IBD);Crohn's Disease (CD);Ulcerative Colitis (UC)Biological: Fecal Microbiota Transplantation (FMT)Children's Mercy Hospital Kansas CityUniversity of Pittsburgh;Stanford UniversityCompleted2 Years22 YearsAll23Phase 1United States
32NCT01947101
(ClinicalTrials.gov)
February 201413/9/2013Fecal Microbiota Transplantation (FMT) for Treatment of Ulcerative Colitis in ChildrenA Phase I Study of Fecal Microbiota Transplantation (FMT) in Immunomodulator Dependent Pediatric Ulcerative Colitis (UC)Ulcerative ColitisBiological: Fecal Microbiota TransplantBaylor College of MedicineNULLCompleted12 Years20 YearsBoth6Phase 1United States
33NCT02033408
(ClinicalTrials.gov)
January 20143/12/2013Manipulating the Microbiome in IBD by Antibiotics and FMTManipulating the Microbiome in IBD by Antibiotics and Fecal Microbiota Transplantation (FMT): a Randomized Controlled TrialExacerbation of Ulcerative Colitis;Ulcerative Colitis, Active Severe;Crohn's ColitisDrug: AB (antibiotics);Drug: CS (corticosteroids) OnlyShaare Zedek Medical CenterNULLCompleted2 Years75 YearsAll28N/ACanada;Finland;Israel;Italy;Poland;Spain
34NCT02058524
(ClinicalTrials.gov)
June 201327/8/2013A Pilot and Feasibility Study of Fecal Microbiota Transplantation for Ulcerative ColitisA Pilot and Feasibility Study of Fecal Microbiota Transplantation for Ulcerative ColitisUlcerative ColitisBiological: fecal microbiota transplantationUniversity of ChicagoNULLTerminated18 Years65 YearsBoth1Phase 1United States
35NCT01790061
(ClinicalTrials.gov)
November 20129/2/2013Standardized Fecal Microbiota Transplantation for Ulcerative ColitisEfficacy, Durability and Safety of Standardized Fecal Microbiota Transplantation in Patients With Moderate to Severe Ulcerative ColitisBacteria;Microbiota;Fecal Microbiota Transplantation;Inflammatory Bowel Disease;Ulcerative ColitisProcedure: Standardized FMT;Drug: Traditional treatmentsThe Second Hospital of Nanjing Medical UniversityAir Force Military Medical University, ChinaRecruiting6 Years80 YearsAll500Phase 2/Phase 3China