97. 潰瘍性大腸炎 Ulcerative colitis Clinical trials / Disease details


臨床試験数 : 2,630 薬物数 : 1,459 - (DrugBank : 265) / 標的遺伝子数 : 144 - 標的パスウェイ数 : 202

  
17 trials found
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1NCT04968951
(ClinicalTrials.gov)
November 10, 20219/7/2021Refined Fecal Microbiota Transplantation (FMT) for Ulcerative Colitis (UC)REFOCUS: Refined Fecal Microbiota Transplantation (FMT) Delivered by Oral Capsules for Induction of Remission in Mild to Moderate Ulcerative Colitis - a Phase I StudyUlcerative Colitis;FMT;Fecal Microbiota TransplantDrug: Metronidazole;Drug: Placebo;Drug: Vancomycin;Biological: Fecal Microbiota TransplantationAri M GrinspanNULLRecruiting18 Years75 YearsAll20Early Phase 1United States
2NCT04979832
(ClinicalTrials.gov)
September 6, 202130/6/2021GM-CSF, Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative IPAA SurgeryA Combined Treatment With GM-CSF, Fosfomycin and Metronidazole for Pouchitis in Ulcerative Colitis Patients After Restorative Ileal Pouch Anal Anastomosis SurgeryPouchitisDrug: GM-CSF, fosfomycin and metronidazoleZealand University HospitalNULLRecruiting18 YearsN/AAll18Phase 1/Phase 2Denmark
3EUCTR2020-000609-10-DK
(EUCTR)
06/07/202123/09/2020A combination of immunesystem stimulating- and antibiotic treatment for inflammation of the pouch in ulcerative colitis patientsA combined treatment with GM-CSF, fosfomycin and metronidazole for pouchitis in ulcerative colitis patients after restorative ileal pouch anal anastomosis surgeryA clinical safety and proof-of-concept study A combination of GM-CSF and metronidazole/fosfomycin treatment for pouchitis in Ulcerative Colitis patients after ileal-pouch-anal anastomosis surgery given as an enema or spray in the pouch.
MedDRA version: 20.0;Level: PT;Classification code 10036463;Term: Pouchitis;System Organ Class: 10017947 - Gastrointestinal disorders;Therapeutic area: Diseases [C] - Digestive System Diseases [C06]
Product Name: Repomol
INN or Proposed INN: Molgramostim
Trade Name: Metronidazole
Product Name: Metronidazole
INN or Proposed INN: METRONIDAZOLE
Other descriptive name: Metronidazole
Trade Name: Fosfomycin
Product Name: Infectofos
INN or Proposed INN: Fosfomycin disodium
Other descriptive name: FOSFOMYCIN DISODIUM
Center for Surgical ScienceNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
26Phase 1;Phase 2Denmark
4NCT03986996
(ClinicalTrials.gov)
July 25, 20194/6/2019Antimicrobial Therapy for Ulcerative Colitis (UC)Antimicrobial Therapy for Ulcerative Colitis : Evaluation of Two Antibiotic Combinations for Refractory Ulcerative ColitisUlcerative ColitisDrug: amoxicillin, metronidazole and doxycycline;Drug: amoxicillin and doxycyclinWolfson Medical CenterNULLTerminated13 Years60 YearsAll20Phase 2Israel
5NCT03794765
(ClinicalTrials.gov)
April 1, 20194/1/2019Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative ColitisUse of Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis: A Randomised TrialUlcerative Colitis;Inflammatory Bowel Diseases;Acute Severe ColitisDrug: Ceftriaxone;Drug: Metronidazole;Other: Placebo infusionPostgraduate Institute of Medical Education and ResearchNULLCompleted13 YearsN/AAll50Phase 2India
6JPRN-jRCTs031180415
01/02/201722/03/2019A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel diseaseSingle center non-randomized study: A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease)
Inflammatory Bowel Disease (Ulcerative Colitis, Crohn's Disease)
AFM therapy arm : three antibiotics, amoxicillin (1500 mg/day), fosfomycin (3000 mg/day) and metronidazole (750 mg/day) are administered orally to patients for 2 weeks. For pediatric patients, amoxicillin (50mg/kg), fosfomycin (120mg/kg) and metronidazole (20mg/kg) are administered orally for 2 weeks (the upper limit is the same amount as adults).
FMT arm : Approximately 150 to 250 g of donor stool is diluted with saline (500 mL) and filtered to remove crude components. The diluted and filtered fecal suspension is transferred into the patients colon from cecum to rectum during total colonoscopy. As usual examinations, the patient undergoes biopsy of inflammatory site.
A-FMT arm : Patient undergoes FMT two days after AFM therapy.
Ishikawa DaiNULLRecruiting>= 6age oldNot applicableBoth120N/AJapan
7JPRN-UMIN000025846
2017/02/0101/02/2017A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel diseaseA trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease - A trial of a combination therapy of fecal microbial transplantation and antibiotics for inflammatory bowel disease ulcerative colitis, Crohn's diseaseAdministration of the fecal material from healthy donors to patients after taking three kinds of antibiotics (Amoxicillin, fosmycin, metronidazole) for two weeksJuntendo university school of medicineDepartment of gastroenterologyNULLRecruiting16years-oldNot applicableMale and Female60Not selectedJapan
8JPRN-UMIN000026485
2016/08/0110/03/2017Research on the Efficacy of Fecal Microbiota Transplantation and Microbiota in Japanese Children with Ulcerative Colitis.Research on the Efficacy of Fecal Microbiota Transplantation and Microbiota in Japanese Children with Ulcerative Colitis. - Research on the Efficacy of FMT to the Children with UC ulcerative colitisFecal Microbiota Transplantation(on Day1, 2 and 3, week 2, 3 and 5) after antibiotic pretreatment using amoxicillin 40mg/kg/day, fosfomycin 100mg/kg/day and metronidazole 16mg/kg/day.National Center for Child Health and Development10Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan. Yakult Central Institute, Tokyo, JapanRecruiting2years-old18years-oldMale and Female12Not selectedJapan
9NCT02606032
(ClinicalTrials.gov)
May 201613/11/2015Trial of Antimicrobials Versus Placebo in Addition to Fecal Transplant Therapy in Ulcerative ColitisRandomized Trial of Antimicrobials Versus Placebo in Addition to Fecal Microbiota Therapy in for the Induction of Remission in Active Ulcerative ColitisUlcerative ColitisDrug: Metronidazole;Drug: Doxycycline;Drug: Terbinafine;Drug: PlaceboHamilton Health Sciences CorporationHamilton Academic Health Sciences OrganizationCompleted18 YearsN/AAll75Phase 2Canada
10JPRN-UMIN000018642
2015/08/1211/08/2015A trial of fecal microbiota transplantation and / or antibiotics therapy for ulcerative colitisA trial of fecal microbiota transplantation and / or antibiotics therapy for ulcerative colitis - A trial of fecal microbiota transplantation and / or antibiotics therapy for ulcerative colitis ulcerative colitisAntibiotics therapy:Taking three kinds of antibiotics (Amoxicillin, fosmycin, metronidazole) for two weeks.
FMT:Administration of the fecal material from healthy donors to patients.
Juntendo university school of medicine Department of gastroenterologyNULLComplete: follow-up complete6years-oldNot applicableMale and Female50Not selectedJapan
11JPRN-UMIN000017844
2015/06/2222/06/2015Antibiotic combination therapy for ulcerative colitisAntibiotic combination therapy for ulcerative colitis - Antibiotic combination therapy for ulcerative colitis ulcerative colitisamoxicillin, tetracycline, and metronidazoleShiga University of Medical ScienceNULLComplete: follow-up complete20years-old80years-oldMale and Female20Not selectedJapan
12JPRN-UMIN000014152
2014/06/0404/06/2014A trial of a combination therapy of fecal microbiota transplantation and antibiotics or simple fecal microbiota therapy for ulcerative colitisA trial of a combination therapy of fecal microbiota transplantation and antibiotics or simple fecal microbiota therapy for ulcerative colitis - A trial of a combination therapy of FMT and antibiotics or FMT for ulcerative colitis ulcerative colitisAdministration of the fecal material from healthy donors to patients after taking three kinds of antibiotics (Amoxicillin, fosmycin, metronidazole) for two weeksJuntendo university school of medicine Department of gastroenterologyNULLComplete: follow-up complete20years-oldNot applicableMale and Female30Not selectedJapan
13JPRN-UMIN000009811
2013/01/2321/01/2013Comparison of randomized trials of antibiotic combination therapies for patients with ulcerative colitisComparison of randomized trials of antibiotic combination therapies for patients with ulcerative colitis - Antibiotics trials for ulcerative colitis Ulcerative colitisOne group is to receive two-week combination therapy consisting of amoxicillin (Sawacillin) 500 mg t.i.d, tetracycline (Acromycin) 500 mg t.i.d, and metronidazole (Flagyl) 250 mg t.i.d. with an inhibitor of gastric acid secretion. Patients are to be followed for 3 months (first endpoint).
Another group will receive two week combination therapy consisting of amoxicillin (Sawacillin) 500 mg t.i.d, fosfomycin (Fosmicin) 1000mg t.i.d, and metrozole (Flagyl) 250 mg t.i.d, with an inhibitor of gastric acid secretion. Patients are to be followed for 3 months.
Division of General Medicine, Department of Internal Medicine, Nihon University School of MedicineNULLComplete: follow-up complete16years-old75years-oldMale and Female40Phase 3Japan
14EUCTR2009-015136-14-BE
(EUCTR)
20/11/200912/10/2009Modified release metronidazole for the treatment of pouchitis after colectomy with ileo-anal pouch anastomosis for ulcerative colitis: a pharmacokinetic studyModified release metronidazole for the treatment of pouchitis after colectomy with ileo-anal pouch anastomosis for ulcerative colitis: a pharmacokinetic study Pouchitis
MedDRA version: 12.0;Level: LLT;Classification code 10036463;Term: Pouchitis
Product Name: Metronidazole capsule 50 mg
Product Code: FP-110
INN or Proposed INN: Metronidazole
Trade Name: Flagyl
INN or Proposed INN: Metronidazole
FORMAC Pharmaceuticals NVNULLNot RecruitingFemale: yes
Male: yes
Belgium
15JPRN-UMIN000048515
2008/10/0131/07/2022A comparative trial between antibiotic combination therapy and steroid therapy for ulcerative colitis patientsA comparative trial between antibiotic combination therapy and steroid therapy for ulcerative colitis patients - A comparative trial between antibiotic combination therapy and steroid therapy for ulcerative colitis patients Ulcerative colitis14 days oral intake of amoxicillin 1500 mg/day, tetracycline 1500 mg/day and metronidazole 750 mg/dayJuntendo UniversityNULLComplete: follow-up continuing18years-oldNot applicableMale and Female350Not selectedJapan
16NCT00355602
(ClinicalTrials.gov)
July 200621/7/2006Antibiotics for the Treatment of Ulcerative ColitisUse of Antibiotics to Eradicate Bacterial Pathogens Colonising the Colonic Mucosa in Ulcerative Colitis PatientsColitis, UlcerativeDrug: Cefuroxime;Drug: Ciprofloxacin;Drug: Clarithromycin;Drug: Cotrimoxazole;Drug: Coamoxiclav;Drug: metronidazole;Drug: neomycin;Drug: rifaximin;Drug: Vancomycin;Drug: DoxycyclineUniversity of DundeeTenovus ScotlandCompleted18 Years79 YearsBoth40N/AUnited Kingdom
17JPRN-C000000078
2003/10/0126/08/2005Antibiotic Combination Therapy in Patients with Active Refractory Ulcerative Colitis: A Prospective Randomized Placebo-controlled Multicenter StudyAntibiotic Combination Therapy in Patients with Active Refractory Ulcerative Colitis: A Prospective Randomized Placebo-controlled Multicenter Study - Antibiotic Combination Therapy in Patients with Active Refractory Ulcerative Colitis Ulcerative ColitisPatients in the treatment group receive an antibiotic combination consisting of amoxicillin 500mg tid, tetracycline 500mg tid, and metronidazole 250mg tid for two weeks.
patients in the control group recieve three kinds of placebo contained sugar.
Japan UC Antibiotics-therapy Study Group(JUCASG)Nihon University,Iwate Medical University, Kyoto Central HospitalYamagata Central HospitalOita University, Tokyo Medical UniversityToyama Medical & Pharmaceutical University, Showa UniversityComplete: follow-up complete15years-old70years-oldMale and Female210Phase 2Japan