144. Lennox-Gastaut syndrome Clinical trials / Disease details
Clinical trials : 111 / Drugs : 72 - (DrugBank : 14) / Drug target genes : 49 - Drug target pathways : 61
Showing 1 to 10 of 111 diseases
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05485831 (ClinicalTrials.gov) | April 2023 | 29/7/2022 | Epidyolex® in Lennox Gastaut and Dravet Syndrome: an Observational Study in ITALY | Observational, Prospective, Multicenter Study of Epidyolex® (Cannabidiol CBD 100 mg/ml) Oral Solution, as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome (DS) Observational, Prospective, Multicenter Study of Epidyolex® (Cannabidiol CBD 100 mg/ml) Oral Solutio ... | Lennox Gastaut Syndrome;Dravet Syndrome | Drug: Epidiolex 100 mg/mL Oral Solution | Jazz Pharmaceuticals | Evidilya S.r.l. | Not yet recruiting | 6 Years | 17 Years | All | 70 | Italy | |
| 2 | NCT05626634 (ClinicalTrials.gov) | November 8, 2022 | 15/11/2022 | Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopa ... | A Phase 2, Multicenter, Open-label, Long-term Safety Study of LP352 in Subjects With Developmental and Epileptic Encephalopathy Who Completed Study LP352-201 and Are Candidates for Continuous Treatment for Up to 52 Weeks A Phase 2, Multicenter, Open-label, Long-term Safety Study of LP352 in Subjects With Developmental a ... | Developmental and Epileptic Encephalopathy;Dravet Syndrome;Lennox-Gastaut Syndrome | Drug: LP352 | Longboard Pharmaceuticals | NULL | Recruiting | 12 Years | 65 Years | All | 50 | Phase 2 | United States |
| 3 | NCT05066217 (ClinicalTrials.gov) | October 1, 2022 | 23/9/2021 | EPX-100 (Clemizole Hydrochloride) as Adjunctive Therapy in Children With Lennox Gastaut Syndrome | A 20-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled, Proof of Concept Trial of EPX-100 (Clemizole Hydrochloride) as Adjunctive Therapy in Children With Lennox-Gastaut Syndrome A 20-Week Multicenter, Randomized, Double-Blind, Placebo-Controlled, Proof of Concept Trial of EPX-1 ... | Lennox Gastaut Syndrome | Drug: Clemizole HCl;Drug: Placebo to match EPX-100 | Epygenix | NULL | Not yet recruiting | 14 Years | N/A | All | 24 | Phase 2 | NULL |
| 4 | NCT05219617 (ClinicalTrials.gov) | April 28, 2022 | 6/1/2022 | Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With LGS in Children and Adults Investigate Efficacy and Safety of Carisbamate as Adjunctive Treatment for Seizures Associated With ... | A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Carisbamate (YKP509) as Adjunctive Treatment for Seizures Associated With Lennox-Gastaut Syndrome in Children and Adults, With Optional Open-Label Extension A Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Caris ... | Seizures;Lennox Gastaut Syndrome | Drug: Carisbamate | SK Life Science, Inc. | NULL | Recruiting | 4 Years | 55 Years | All | 252 | Phase 3 | United States;Colombia;Israel;Korea, Republic of;Mexico |
| 5 | EUCTR2021-002482-17-ES (EUCTR) | 04/04/2022 | 20/12/2021 | Open-Label Extension Study of Soticlestat in Dravet and Lennox-Gastaut Syndromes | A Phase 3, Prospective, Open-Label, Multisite, Extension of Phase 3 Studies To Assess the Long-Term Safety and Tolerability of Soticlestat as Adjunctive Therapy in Subjects With Dravet Syndrome or Lennox-Gastaut Syndrome (ENDYMION 2). A Phase 3, Prospective, Open-Label, Multisite, Extension of Phase 3 Studies To Assess the Long-Term ... | Dravet Syndrome (DS)Lennox-Gastaut Syndrome (LGS) MedDRA version: 20.0;Level: LLT;Classification code 10073682;Term: Dravet syndrome;System Organ Class: 100000004850 MedDRA version: 20.1;Level: PT;Classification code 10048816;Term: Lennox-Gastaut syndrome;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] Dravet Syndrome (DS)Lennox-Gastaut Syndrome(LGS) MedDRA version: 20.0;Level: LLT;Classification code ... | Product Name: soticlestat Product Code: TAK-935 INN or Proposed INN: SOTICLESTAT Product Name: soticlestat Product Code: TAK-935 INN or Proposed INN: SOTICLESTAT Product Name: soticlestat Product Code: TAK-935 INN or Proposed INN: SOTICLESTAT Product Name: soticles ... | Takeda Development Center Americas, Inc | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 376 | Phase 3 | United States;Serbia;Greece;Spain;Ukraine;Russian Federation;Italy;France;Hungary;Canada;Belgium;Poland;Australia;Latvia;Netherlands;China;Japan United States;Serbia;Greece;Spain;Ukraine;Russian Federation;Italy;France;Hungary;Canada;Belgium;Pol ... | ||
| 6 | EUCTR2021-002482-17-GR (EUCTR) | 17/03/2022 | 24/01/2022 | Open-Label Extension Study of Soticlestat in Dravet and Lennox-Gastaut Syndromes | A Phase 3, Prospective, Open-Label, Multisite, Extension of Phase 3 Studies To Assess the Long-Term Safety and Tolerability of Soticlestat as Adjunctive Therapy in Subjects With Dravet Syndrome or Lennox-Gastaut Syndrome (ENDYMION 2). A Phase 3, Prospective, Open-Label, Multisite, Extension of Phase 3 Studies To Assess the Long-Term ... | Dravet Syndrome (DS)Lennox-Gastaut Syndrome (LGS) MedDRA version: 20.0;Level: LLT;Classification code 10073682;Term: Dravet syndrome;System Organ Class: 100000004850 MedDRA version: 20.1;Level: PT;Classification code 10048816;Term: Lennox-Gastaut syndrome;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] Dravet Syndrome (DS)Lennox-Gastaut Syndrome(LGS) MedDRA version: 20.0;Level: LLT;Classification code ... | Product Name: soticlestat Product Code: TAK-935 INN or Proposed INN: SOTICLESTAT Product Name: soticlestat Product Code: TAK-935 INN or Proposed INN: SOTICLESTAT Product Name: soticlestat Product Code: TAK-935 INN or Proposed INN: SOTICLESTAT Product Name: soticles ... | Takeda Development Center Americas, Inc | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 376 | Phase 3 | Serbia;United States;Greece;Spain;Ukraine;Russian Federation;Italy;France;Hungary;Canada;Poland;Belgium;Australia;Latvia;Netherlands;China;Japan Serbia;United States;Greece;Spain;Ukraine;Russian Federation;Italy;France;Hungary;Canada;Poland;Belg ... | ||
| 7 | EUCTR2021-002482-17-NL (EUCTR) | 17/03/2022 | 27/12/2021 | Open-Label Extension Study of Soticlestat in Dravet and Lennox-Gastaut Syndromes | A Phase 3, Prospective, Open-Label, Multisite, Extension of Phase 3 Studies To Assess the Long-Term Safety and Tolerability of Soticlestat as Adjunctive Therapy in Subjects With Dravet Syndrome or Lennox-Gastaut Syndrome (ENDYMION 2). A Phase 3, Prospective, Open-Label, Multisite, Extension of Phase 3 Studies To Assess the Long-Term ... | Dravet Syndrome (DS)Lennox-Gastaut Syndrome (LGS) MedDRA version: 20.0;Level: LLT;Classification code 10073682;Term: Dravet syndrome;System Organ Class: 100000004850 MedDRA version: 20.1;Level: PT;Classification code 10048816;Term: Lennox-Gastaut syndrome;System Organ Class: 10029205 - Nervous system disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10] Dravet Syndrome (DS)Lennox-Gastaut Syndrome(LGS) MedDRA version: 20.0;Level: LLT;Classification code ... | Product Name: soticlestat Product Code: TAK-935 INN or Proposed INN: SOTICLESTAT Product Name: soticlestat Product Code: TAK-935 INN or Proposed INN: SOTICLESTAT Product Name: soticlestat Product Code: TAK-935 INN or Proposed INN: SOTICLESTAT Product Name: soticles ... | Takeda Development Center Americas, Inc | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: yes | 376 | Phase 3 | United States;Serbia;Greece;Spain;Ukraine;Russian Federation;Italy;France;Hungary;Canada;Belgium;Poland;Australia;Netherlands;Latvia;China;Japan United States;Serbia;Greece;Spain;Ukraine;Russian Federation;Italy;France;Hungary;Canada;Belgium;Pol ... | ||
| 8 | NCT05163314 (ClinicalTrials.gov) | March 4, 2022 | 15/12/2021 | A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Ga ... | A Phase 3, Prospective, Open-Label, Multisite, Extension of Phase 3 Studies To Assess the Long-Term Safety and Tolerability of Soticlestat as Adjunctive Therapy in Subjects With Dravet Syndrome or Lennox-Gastaut Syndrome (ENDYMION 2) A Phase 3, Prospective, Open-Label, Multisite, Extension of Phase 3 Studies To Assess the Long-Term ... | Dravet Syndrome (DS);Lennox Gastaut Syndrome (LGS) | Drug: Soticlestat | Takeda | NULL | Recruiting | 2 Years | 56 Years | All | 376 | Phase 3 | United States;Australia;Belgium;Brazil;Canada;China;France;Germany;Greece;Hungary;Italy;Japan;Latvia;Mexico;Netherlands;Poland;Russian Federation;Serbia;Spain;Ukraine United States;Australia;Belgium;Brazil;Canada;China;France;Germany;Greece;Hungary;Italy;Japan;Latvia ... |
| 9 | JPRN-jRCT2051210182 | 04/03/2022 | 02/03/2022 | A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Ga ... | A Phase 3, Prospective, Open-Label, Multisite, Extension of Phase 3 Studies To Assess the Long-Term Safety and Tolerability of Soticlestat as Adjunctive Therapy in Subjects With Dravet Syndrome or Lennox-Gastaut Syndrome (ENDYMION 2) - ENDYMION 2 A Phase 3, Prospective, Open-Label, Multisite, Extension of Phase 3 Studies To Assess the Long-Term ... | Dravet Syndrome (DS), Lennox Gastaut Syndrome (LGS) | Participants with DS and LGS will receive: Participants weighing <45 kg: Soticlestat, mini-tablets, titrated from lower dose level (60mg to 140mg) to higher dose (100mg to 200mg) twice daily (BID), based on body weight, orally/via gastrostomy tube (G-tube) or percutaneous endoscopic gastrostomy (PEG) tube, up to 2 weeks in Titration Period. Will continue to receive dose that they are on at the end of Titration Period, for approximately 4 years in Maintenance Period. Dose will be tapered down to lower dose (not less than the lowest dose level based on weight) every 3 days until study drug is discontinued (up to 1 week) in Taper Period. Participants weighing >= 45kg or adults: Soticlestat mini-tablets or tablets with starting dose of 200 mg BID followed by 300 mg BID, up to 2 weeks in Titration Period. Will continue to receive 300 mg BID for approximately 4 years in Maintenance Period. Dose will be tapered down up to 100 mg every 3 days until study drug is discontinued (up to 1 week) in Taper Period. Participants with DS and LGS will receive: Participants weighing <45 kg: Soticlestat, mini-tablets, ... | Nonomura Hidenori | NULL | Recruiting | >= 2age old | <= 36age old | Both | 376 | Phase 3 | Australia;Belgium;Canada;China;Spain;France;United Kingdom;Greece;Hungary;Italy;Latvia;Netherlands;Poland;Serbia;Russia;Ukraine;USA;Japan Australia;Belgium;Canada;China;Spain;France;United Kingdom;Greece;Hungary;Italy;Latvia;Netherlands;P ... |
| 10 | NCT05364021 (ClinicalTrials.gov) | March 3, 2022 | 22/3/2022 | Study to Investigate LP352 in Subjects With Developmental and Epileptic Encephalopathies | Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose-escalation Study to Investigate the Safety, Tolerability, PK, PD, and Exploratory Efficacy of LP352 in Subjects With Developmental and Epileptic Encephalopathies Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose-escalation Study to Investigate t ... | Developmental and Epileptic Encephalopathy;Dravet Syndrome;Lennox Gastaut Syndrome | Drug: LP352;Drug: Placebo | Longboard Pharmaceuticals | NULL | Recruiting | 12 Years | 65 Years | All | 50 | Phase 1/Phase 2 | United States |