Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	Disease ID
1	SIGMAR1	[2] Amyotrophic lateral sclerosis, Pathways of neurodegeneration - multiple diseases	D07945	Fenfluramine	[4] 140, 144, 145, 149
2	CYP46A1	[1] Primary bile acid biosynthesis	D11590	Soticlestat	[1] 144
3	CNR1	[4] Rap1 signaling pathway, Neuroactive ligand-receptor interaction, Thermogenesis, Retrograde endoc ...	D10915	Cannabidiol	[20] 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
4	CNR2	[1] Neuroactive ligand-receptor interaction	D10915	Cannabidiol	[9] 144, 145, 156, 157, 158, 193, 206, 226, 271
5	GABRA1	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...	D00537	Topiramate	[6] 6, 97, 140, 144, 156, 193
6	GABRA1	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...	D01253	Clobazam	[2] 140, 144
7	GABRA2	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...	D00537	Topiramate	[6] 6, 97, 140, 144, 156, 193
8	GABRA2	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...	D01253	Clobazam	[2] 140, 144
9	GABRA3	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...	D00537	Topiramate	[6] 6, 97, 140, 144, 156, 193
10	GABRA3	[6] Neuroactive ligand-receptor interaction, Retrograde endocannabinoid signaling, GABAergic synapse ...	D01253	Clobazam	[2] 140, 144

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