206. Fragile X syndrome Clinical trials / Disease details
Clinical trials : 108 / Drugs : 91 - (DrugBank : 36) / Drug target genes : 52 - Drug target pathways : 77
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05120505 (ClinicalTrials.gov) | December 29, 2021 | 3/11/2021 | Metformin in Children With Fragile X Syndrome | Efficacy and Safety of Metformin in the Treatment of Fragile X Syndrome | Fragile X Syndrome;Metformin | Drug: Metformin;Drug: Placebo | Children's Hospital of Fudan University | NULL | Recruiting | 2 Years | 16 Years | All | 20 | Phase 4 | China |
| 2 | NCT04141163 (ClinicalTrials.gov) | October 29, 2019 | 24/10/2019 | Metformin in Patients With Fragile X | A Parallel Group Design Randomized Double-Blind Trial of Metformin Treatment in Patients With Fragile X Syndrome on Safety and Effects on Cognition, Anxiety, Attention and Biomarkers | Fragile X Syndrome | Drug: Metformin;Drug: Placebo oral tablet | Rowan University | FRAXA Research Foundation;University of Pennsylvania | Recruiting | 18 Years | 50 Years | Male | 40 | Phase 1/Phase 2 | United States |
| 3 | NCT03862950 (ClinicalTrials.gov) | May 24, 2019 | 26/2/2019 | A Trial of Metformin in Individuals With Fragile X Syndrome (Met) | A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals With Fragile X Syndrome (FXS) | Fragile X Syndrome;Fragile X Mental Retardation Syndrome;Mental Retardation, X-Linked;Genetic Diseases, X-Linked;Trinucleotide Repeat Expansion;Fra(X) Syndrome;Intellectual Disability;FXS;Neurobehavioral Manifestations;Sex Chromosome Disorders | Drug: Placebo Medication;Drug: Metformin | University of Alberta | St. Justine's Hospital | Recruiting | 6 Years | 35 Years | All | 120 | Phase 2 | Canada |
| 4 | NCT03722290 (ClinicalTrials.gov) | September 1, 2018 | 24/10/2018 | Metformin in Children and Adults With Fragile X Syndrome | Evaluate the Efficacy and Safety of Metformin in Children and Adults With Fragile X Syndrome: an Open-label Study | Fragile X Syndrome | Drug: Metformin | Université de Sherbrooke | FRAXA Research Foundation | Completed | 10 Years | 45 Years | All | 15 | Phase 2 | Canada |
| 5 | NCT03479476 (ClinicalTrials.gov) | April 30, 2018 | 20/3/2018 | A Trial of Metformin in Individuals With Fragile X Syndrome | A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals With Fragile X Syndrome | Fragile X Syndrome;Fragile X Mental Retardation Syndrome;Mental Retardation, X Linked;Genetic Diseases, X-Linked;Trinucleotide Repeat Expansion;Fra(X) Syndrome;Intellectual Disability;FXS;Neurobehavioral Manifestations;Sex Chromosome Disorders | Drug: Placebo Medication;Drug: Metformin | University of California, Davis | NULL | Completed | 6 Years | 25 Years | All | 55 | Phase 2/Phase 3 | United States |