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No. Drug (Description in trials) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY Disease ID
111C-flumazenil[1] Flumazenil[1] D00697 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 206
218F-FTC-146----[1] 206
35-Hydroxytryptophan / Vitamin B6[1] Pyridoxine[1] D08454 --[1] 206
4[15-O]water[1] Water[1] D00001 --[1] 206
5[18F]flumazenil[1] Flumazenil[1] D00697 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 206
6[18F]FPEB----[3] 6, 8, 206
7[18F]FPEB PET imaging----[1] 206
8Acamprosate[1] Acamprosate[1] D07058 [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[2] 6, 206
9Acetate[1] Acetate---[41] 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299
10Acidum ascorbicum[1] Ascorbic acid[1] D00018 --[1] 206
11ACIDUM ASCORBICUM D6[1] Ascorbic acid[1] D00018 --[1] 206
12AF056----[1] 206
13AFQ056----[3] 6, 8, 206
14Alpha-tocopherol[2] Tocopherol,
Vitamin E		[2] D02331 ,
D02332 		--[2] 49, 206
15Ampalex----[1] 206
16Arbaclofen[1] Arbaclofen[1] D09791 [2] GABBR1,
GABBR2 💬		[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬[2] 13, 206
17Aripiprazole[1] Aripiprazole[1] D01164 [4] DRD2,
DRD3,
HTR1A,
HTR2A 💬		[12] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, Taste transduction, cAMP signaling pathway 💬[2] 6, 206
18Ascorbic acid[1] Ascorbic acid[1] D00018 --[4] 10, 97, 206, 298
19Ascorbic Acid (Vitamin C) and Alpha-tocopherol (Vitamin E)[3] Ascorbic acid,
Tocopherol,
Vitamin E		[3] D00018 ,
D02331 ,
D02332 		--[1] 206
20AZD7325----[1] 206
21AZD7325 (High-Dose)----[1] 206
22AZD7325 (Low-Dose)----[1] 206
23Baclofen[1] Baclofen[1] D00241 [2] GABBR1,
GABBR2 💬		[7] Estrogen signaling pathway, GABAergic synapse, GnRH secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Taste transduction, cAMP signaling pathway 💬[8] 2, 10, 13, 18, 65, 70, 149, 206
24BPN14770----[1] 206
25BPN14770/ zatolmilast[1] Zatolmilast[1] D12173 [1] PDE4D 💬[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[1] 206
26Cannabidiol[1] Cannabidiol[1] D10915 [2] CNR1,
CNR2 💬		[4] Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬[18] 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
27CBD----[13] 2, 6, 8, 13, 36, 46, 51, 140, 144, 145, 156, 158, 206
28CCD 1042, MD 9150000, Mepalon 1042, SPT316----[2] 152, 206
29CX516[1] CX516---[1] 206
30CX516 (Ampalex®)[1] CX516---[1] 206
31Donepezil[1] Donepezil[1] D07869 [1] ACHE 💬[2] Cholinergic synapse, Glycerophospholipid metabolism 💬[9] 5, 6, 13, 46, 78, 124, 127, 156, 206
32EGCG[1] Epigallocatechin gallate---[9] 6, 8, 13, 17, 28, 85, 113, 206, 299
33EGCG FontUp[1] Epigallocatechin gallate---[1] 206
34Ergoloid Mesylate[1] Ergoloid mesylate---[1] 206
35Flumazenil[1] Flumazenil[1] D00697 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[5] 6, 13, 17, 18, 206
36Fluoxetin[1] Fluoxetine[1] D00326 [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[3] 13, 179, 206
37Gaboxadol[1] Gaboxadol[1] D04282 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[2] 201, 206
38Gaboxadol (HLX-0206)[1] Gaboxadol[1] D04282 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 206
39Ganaxolone[1] Ganaxolone[1] D04300 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[4] 145, 152, 158, 206
40Lovastatin[1] Lovastatin[1] D00359 [1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[11] 6, 34, 46, 79, 156, 160, 195, 206, 263, 280, 310
41Lovastatin, then Minocycline/Lovastatin[2] Lovastatin,
Minocycline		[2] D00359 ,
D05045 		[1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[1] 206
42Mavoglurant[1] Mavoglurant---[2] 6, 206
43Memantine[1] Memantine[1] D08174 [5] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬[8] 2, 6, 8, 13, 49, 127, 205, 206
44Metformin[1] Metformin[1] D04966 [2] PRKAA1,
PRKAA2 💬		[20] AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬[25] 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301
45Methylphenidate[1] Methylphenidate[1] D04999 [2] SLC6A2,
SLC6A3 💬		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[7] 6, 13, 34, 84, 113, 179, 206
46Methylphenidate Oral Solution[1] Methylphenidate[1] D04999 [2] SLC6A2,
SLC6A3 💬		[7] Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬[1] 206
47Methylphenidate, fluoxetin, risperidone[3] Fluoxetine,
Methylphenidate,
Risperidone		[3] D00326 ,
D00426 ,
D04999 		[5] DRD2,
HTR2A,
SLC6A2,
SLC6A3,
SLC6A4 💬		[14] Alcoholism, Amphetamine addiction, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Rap1 signaling pathway, Serotonergic synapse, Synaptic vesicle cycle, cAMP signaling pathway 💬[2] 179, 206
48MG01CI extended-release tablet[1] Manganese citrate---[1] 206
49MGlu5 antagonist----[1] 206
50Minocycline[1] Minocycline[1] D05045 --[13] 2, 6, 8, 13, 46, 85, 90, 94, 162, 201, 206, 280, 299
51Minocycline Hydrochloride[1] Minocycline[1] D05045 --[4] 13, 201, 206, 299
52Minocycline, then Minocycline/Lovastatin[2] Lovastatin,
Minocycline		[2] D00359 ,
D05045 		[1] HMGCR 💬[4] AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬[1] 206
53NNZ-2566----[2] 156, 206
54Non invasive prenatal diagnosis----[3] 8, 113, 206
55NPL-2009----[1] 206
56OV101----[2] 201, 206
57OV101 (gaboxadol)[1] Gaboxadol[1] D04282 [16] GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		[7] GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬[1] 206
58Oxytocin[1] Oxytocin[1] D00089 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[7] 6, 72, 127, 168, 193, 206, 226
59Oxytocin 24IU[1] Oxytocin[1] D00089 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[1] 206
60Oxytocin 48IU[1] Oxytocin[1] D00089 [1] OXTR 💬[4] Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬[1] 206
61Release[1] Manganese citrate---[12] 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299
62RILUZOLE[1] Riluzole[1] D00775 [14] GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		[23] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬[9] 2, 3, 5, 8, 13, 17, 18, 203, 206
63Risperidone[1] Risperidone[1] D00426 [2] DRD2,
HTR2A 💬		[11] Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬[5] 8, 156, 179, 187, 206
64Ro 491-7523/F18----[1] 206
65Ro 491-7523/F19----[1] 206
66RO4917523----[1] 206
67RO4917523 0.5 mg----[1] 206
68RO4917523 1.5 mg----[1] 206
69Roflumilast[1] Roflumilast[1] D05744 [4] PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[4] 84, 97, 206, 299
70Sertraline[1] Sertraline[1] D02360 [1] SLC6A4 💬[2] Serotonergic synapse, Synaptic vesicle cycle 💬[2] 6, 206
71STX107----[1] 206
72STX209----[1] 206
73Sugar pill----[8] 5, 6, 49, 67, 70, 86, 206, 210
74Sulindac[1] Sulindac[1] D00120 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 206
75Sulindac (HLX-0201), dose strength 1[1] Sulindac[1] D00120 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 206
76Sulindac (HLX-0201), dose strength 2[1] Sulindac[1] D00120 [2] PTGS1,
PTGS2 💬		[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬[1] 206
77Tocopherol[1] Tocopherol[1] D02332 --[5] 13, 49, 206, 257, 298
78TOCOPHERYL ACETATE[2] Acetate,
alpha-Tocopherol acetate		---[1] 206
79Vitamin B6[1] Pyridoxine[1] D08454 --[2] 6, 206
80Vitamin C[1] Ascorbic acid[1] D00018 --[6] 10, 192, 206, 210, 211, 212
81Vitamin E[1] Vitamin E[1] D02331 --[11] 2, 6, 13, 20, 46, 90, 96, 97, 206, 299, 317
82Water[1] Water[1] D00001 --[21] 2, 5, 6, 13, 17, 22, 35, 46, 53, 57, 63, 65, 67, 78, 84, 96, 97, 206, 226, 278, 299
83Zatolmilast[1] Zatolmilast[1] D12173 [1] PDE4D 💬[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[1] 206
84Zatolmilast/ BPN14770[1] Zatolmilast[1] D12173 [1] PDE4D 💬[5] Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬[1] 206
85ZYN002----[2] 203, 206
86ZYN002 - CBD Transdermal Gel----[1] 206
87ZYN002 - transdermal gel----[1] 206