86. Pulmonary arterial hypertension Clinical trials / Disease details

Clinical trials : 1,205 / Drugs : 684 - (DrugBank : 124) / Drug target genes : 100 - Drug target pathways : 193

1097 trials found

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05660863 (ClinicalTrials.gov)	June 1, 2023	1/12/2022	A Multiple Dose Study to Investigate Safety, Tolerability and Pharmacokinetics of MN-08 Tablets	A Bridged Phase 1, Randomized, Double-blind, Placebo-controlled Study to Investigate the Safety, Tol ...	Pulmonary Arterial Hypertension	Drug: MN-08 24 mg/day;Drug: MN-08 60 mg/day	Guangzhou Magpie Pharmaceuticals Co., Ltd.	NULL	Not yet recruiting	18 Years	45 Years	All	16	Phase 1	NULL
2	NCT05731492 (ClinicalTrials.gov)	March 28, 2023	9/2/2023	A Study of Macitentan in Children Below 2 Years of Age	A Multicenter, Open-label, Single-arm Study to Assess the Pharmacokinetics and Safety of Macitentan ...	Arterial Hypertension, Pulmonary	Drug: Macitentan	Actelion	NULL	Recruiting	1 Month	2 Years	All	10	Phase 1	Germany;Poland
3	NCT05764265 (ClinicalTrials.gov)	March 27, 2023	10/1/2023	Extension Study of Efficacy and Safety of LTP001 in Pulmonary Arterial Hypertension Participants	An Open-label Extension Study to Investigate Efficacy, Safety and Tolerability of LTP001 in Particip ...	Pulmonary Arterial Hypertension	Drug: LTP001	Novartis Pharmaceuticals	NULL	Not yet recruiting	18 Years	75 Years	All	40	Phase 2	NULL
4	NCT05649748 (ClinicalTrials.gov)	February 28, 2023	6/12/2022	A Study to Assess the Safety, Tolerability, and Effectiveness of the Long-Term Use of Treprostinil P ...	An Open-Label Extension Study to Assess the Safety, Tolerability, and Effectiveness of the Long-Term ...	Pulmonary Arterial Hypertension	Drug: Treprostinil Palmitil;Drug: Placebo	Insmed Incorporated	NULL	Recruiting	18 Years	N/A	All	100	Phase 2/Phase 3	Japan
5	NCT04778046 (ClinicalTrials.gov)	February 15, 2023	26/2/2021	Pulmonary Hypertension SOLAR	Defining a Noninvasive Signature for Pulmonary Vascular Remodeling in Group 3 PH	Interstitial Lung Disease;COPD;Pulmonary Arterial Hypertension	Drug: Hyperpolarized 129Xe	Bastiaan Driehuys	NULL	Recruiting	18 Years	N/A	All	30	Phase 2	United States
6	NCT05587712 (ClinicalTrials.gov)	January 19, 2023	17/10/2022	Study to Evaluate Sotatercept (MK-7962) in Children With Pulmonary Arterial Hypertension (PAH) (MK-7 ...	A Phase 2 Open-label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynam ...	Pulmonary Arterial Hypertension	Drug: Sotatercept	Merck Sharp & Dohme LLC	NULL	Recruiting	1 Year	17 Years	All	42	Phase 2	United States
7	NCT05179356 (ClinicalTrials.gov)	January 1, 2023	16/12/2021	Dapagliflozin in Pulmonary Arterial Hypertension	Effects of DAPAgliflozin on Cardiopulmonary Exercise Capacity and Hemodynamics in Pulmonary Arterial ...	Pulmonary Arterial Hypertension;Chronic Thromboembolic Pulmonary Hypertension	Drug: Dapagliflozin 10 MG [Farxiga];Drug: Placebo	Mads Ersbøll	NULL	Not yet recruiting	18 Years	N/A	All	52	Phase 2	NULL
8	EUCTR2022-000478-25-ES (EUCTR)	23/12/2022	13/10/2022	Sotatercept in Children with Pulmonary Artery Hypertension on Standard of Care	A Phase 2 Open-label Study to Evaluate the Safety, Tolerability,Pharmacokinetics, and Pharmacodynami ...	Pulmonary arterial hypertension MedDRA version: 21.1;Level: LLT;Classification code 10037403;Term: P ...	Product Name: Sotatercept Product Code: MK-7962 INN or Proposed INN: Sotatercept	Merck Sharp & Dohme LLC	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	42	Phase 2	United States;Spain;Turkey;Israel;Colombia;United Kingdom;France;Mexico;Poland;Australia;South Afric ...
9	EUCTR2019-004131-24-PT (EUCTR)	16/12/2022	25/08/2022	A Phase 3 study to evaluate whether macitentan 75 mg is an effective and safe treatment for patients ...	A prospective, randomized, double-blind, multicenter, placebo-controlled, parallel group, adaptive P ...	Chronic thromboembolic pulmonary hypertension MedDRA version: 21.1;Level: PT;Classification code 100 ...	Trade Name: Opsumit ® Product Name: Macitentan tablets Product Code: JNJ-67896062 / ACT-064992 INN or Pro ...	ACTELION Pharmaceuticals Ltd.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	230	Phase 3	Russian Federation;Singapore;United States;Czechia;Thailand;Portugal;Saudi Arabia;Austria;China;Kore ...
10	EUCTR2021-001910-13-NL (EUCTR)	08/12/2022	16/02/2022	Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial (IMPAHCT) or A Phase 2b/3, Randomize ...	IMPAHCT: A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confir ...	Pulmonary Arterial Hypertension (PAH) MedDRA version: 21.1;Level: PT;Classification code 10064911;Te ...	Product Name: AV-101 INN or Proposed INN: IMATINIB Other descriptive name: Not Available Product Name: ...	Aerovate Therapeutics, Inc.	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	462	Phase 2;Phase 3	United States;Portugal;Greece;Spain;Ireland;Chile;Israel;Colombia;Italy;France;Australia;South Afric ...

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