Isosorbide ( DrugBank: Isosorbide )


1 disease
告示番号疾患名(ページ内リンク)臨床試験数
113筋ジストロフィー2

113. 筋ジストロフィー


臨床試験数 : 646 薬物数 : 471 - (DrugBank : 105) / 標的遺伝子数 : 59 - 標的パスウェイ数 : 170
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1EUCTR2013-004427-37-IT
(EUCTR)
01/10/201404/09/2014Efficacy and tolerability of ibuprofen and isosorbide dinitrate (20 mg, 40 mg, 60 mg, 80 mg)Multicentre, randomised, double-blind, dose titration design in patients with Duchenne muscular dystrophy to evaluate the efficacy and the tolerability of the combinations of Ibuprofen (200 mg bid) and Isosorbide Dinitrate (20 mg, 40 mg, 60 mg, 80 mg) - ESPP001 Restrictive respiratory syndrome with frequent pulmonary infections and cardiomyopathy.wasting of skeletal muscle, severe local inflammation and, at least initially, muscle regeneration.
MedDRA version: 17.0;Level: PT;Classification code 10064571;Term: Gene mutation;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Body processes [G] - Genetic Phenomena [G05]
Trade Name: Isosorbide Dinitrate 20 mg
Product Name: Isosorbide Dinitrate
INN or Proposed INN: ISOSORBIDE DINITRATE
Trade Name: IBUPROFEN 200MG
INN or Proposed INN: IBUPROFEN
Trade Name: Isosorbide Dinitrate 40 mg
Product Name: Isosorbide Dinitrate
INN or Proposed INN: ISOSORBIDE DINITRATE
Trade Name: Isosorbide Dinitrate 60 mg
Product Name: Isosorbide Dinitrate
INN or Proposed INN: ISOSORBIDE DINITRATE
Trade Name: Isosorbide Dinitrate 80 mg
Product Name: Isosorbide Dinitrate
INN or Proposed INN: ISOSORBIDE DINITRATE
PARENT PROJECT ONLUSNULLAuthorised-recruitment may be ongoing or finishedFemale: no
Male: yes
188Italy
2NCT01478022
(ClinicalTrials.gov)
October 201114/11/2011To Compare the Pharmacokinetics Profiles of ISO 20, IBU 200 and IBU Plus ISO Combinations 200 + 20Open, Randomized, 3 Period Cross-over Design, in Healthy Volunteers to Compare the Pharmacokinetics Profiles of 3 Treatments: ISO 20, IBU 200 and IBU Plus ISO Combinations (200 + 20) Administered Per os as Single DosesDuchenne Muscular Dystrophy (DMD)Drug: Isosorbide Dinitrate;Drug: Ibuprofen;Other: Ibuprofen and Isosorbide Dinitrate combinationParent Project, ItalyNULLCompleted18 Years27 YearsAll12Phase 1Italy