HYDROXYCHLOROQUINE SULFATE ( DrugBank: Hydroxychloroquine, Sulfate )

4 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
13	多発性硬化症／視神経脊髄炎	1
46	悪性関節リウマチ	7
53	シェーグレン症候群	6
66	IgA腎症	3

13. 多発性硬化症／視神経脊髄炎

臨床試験数 : 3,340 / 薬物数 : 2,163 - (DrugBank : 383) / 標的遺伝子数 : 241 - 標的パスウェイ数 : 238

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2022-003170-23-FI (EUCTR)	20/12/2022	30/09/2022	Hydroxychloroquine in progressive MS	Prospective, randomized, double-blind, placebo-controlled, single-center comparative trial evaluatin ...	Progressive multiple sclerosis MedDRA version: 21.1;Level: PT;Classification code 10053395;Term: Pro ...	Trade Name: Oxiklorin Product Name: Oxiklorin INN or Proposed INN: Hydroxychloroquine sulfate	Varsinais-Suomen sairaanhoitopiirin kuntayhtymä	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	30	Phase 2	Finland

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46. 悪性関節リウマチ

臨床試験数 : 4,356 / 薬物数 : 2,567 - (DrugBank : 415) / 標的遺伝子数 : 192 - 標的パスウェイ数 : 228

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2011-004720-35-NO (EUCTR)	04/05/2015	26/01/2015	A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheuma ...	A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheuma ...	Rheumatoid arthritis (RA) MedDRA version: 18.0;Level: PT;Classification code 10039073;Term: Rheumato ...	Trade Name: Cimzia INN or Proposed INN: CERTOLIZUMAB PEGOL Trade Name: Orencia INN or Proposed INN: ABA ...	Karolinska Institutet	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	800	Phase 4	Finland;Denmark;Norway;Sweden
2	EUCTR2011-004720-35-FI (EUCTR)	10/09/2014	09/09/2014	A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheuma ...	A multicenter, randomized, open-label, blinded-assessor, phase 4 study in patients with early rheuma ...	Rheumatoid arthritis (RA) MedDRA version: 17.0;Level: PT;Classification code 10039073;Term: Rheumato ...	Trade Name: Cimzia INN or Proposed INN: CERTOLIZUMAB PEGOL Trade Name: Orencia INN or Proposed INN: ABA ...	Karolinska Institutet	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes		Phase 4	Finland;Denmark;Sweden
3	ChiCTR-TRC-14004520	2014-05-01	2014-04-13	To study the signal pathways of Rheumatoid Arthritis Syndrome of Accumulated Dampness and interventi ...	To study the signal pathways of Rheumatoid Arthritis Syndrome of Accumulated Dampness and interventi ...	rheumatoid arthritis	two:Methotrexate, hydroxychloroquine sulfatepills and NSAIDs in both groups; Sanhuang Yinong decocti ...	General Hospital of Chengdu Military Region	NULL	Recruiting	45	65	Both	two:240;RA patients:40;	I (Phase 1 study)	China
4	EUCTR2013-003658-26-NL (EUCTR)	13/11/2013	18/10/2013	Individualised treatment strategy based on disease activity for early RA patients in usual clinical ...	Treat-to-target strategy for early RA patients in usual clinical practice: The COBRA Cohort Study - ...	Early Active Rheumatoid Arthritis;Therapeutic area: Diseases [C] - Immune System Diseases [C20]	Trade Name: Methotrexate Product Name: Methotrexate INN or Proposed INN: Methotrexate Other descriptive ...	VU University Medical Center	NULL	Not Recruiting			Female: yes Male: yes	120	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (P ...	Netherlands
5	EUCTR2009-015740-42-DE (EUCTR)	12/05/2010	12/01/2010	A PHASE 3, MULTICENTER, RANDOMIZED, OPEN, PROSPECTIVE, CONTROLLED, PARALLEL-GROUP STUDY OF REDUCTION ...	A PHASE 3, MULTICENTER, RANDOMIZED, OPEN, PROSPECTIVE, CONTROLLED, PARALLEL-GROUP STUDY OF REDUCTION ...	Rheumatoid arthritis MedDRA version: 17.1;Level: PT;Classification code 10039073;Term: Rheumatoid ar ...	Product Name: Prednisolon Product Code: Prednisolon INN or Proposed INN: PREDNISOLONE Trade Name: Humir ...	Universitätsklinkum Erlangen	NULL	Not Recruiting			Female: yes Male: yes	318	Phase 3	Germany
6	ChiCTR2100043373	2009-07-01	2021-02-12	Clinical study of Hydroxychloroquine Sulfateand sulfasalazine in the treatment of active rheumatoid ...	Clinical study of Hydroxychloroquine Sulfateand sulfasalazine in the treatment of active rheumatoid ...	rheumatoid arthritis	group one:HCQ(200mg/d)+MTX;group two:HCQ(400mg/d)+MTX;group three:HCQ(200mg/d)+SASP+MTX;group four:S ...	Renji Hospital, Shanghai Jiaotong University School of Medicine	NULL	Completed			Both	group one:50;group two:50;group three:50;group four:50;	Phase 4	china
7	EUCTR2006-006186-16-NL (EUCTR)	30/01/2007	16/07/2007	IMPROVED: Induction therapy with Methotrexate and Prednisone in Rheumatoid Or Very Early arthritic D ...	IMPROVED: Induction therapy with Methotrexate and Prednisone in Rheumatoid Or Very Early arthritic D ...	rheumatoid arthritis and undifferentiated arthritis MedDRA version: 8.1;Level: LLT;Classification co ...	Product Name: Methotrexate Product Code: MTX INN or Proposed INN: METHOTREXATE Product Name: Prednisone ...	Leiden University Medical Center, department of rheumatology	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes			Netherlands

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53. シェーグレン症候群

臨床試験数 : 305 / 薬物数 : 325 - (DrugBank : 104) / 標的遺伝子数 : 58 - 標的パスウェイ数 : 188

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2019-002470-32-NL (EUCTR)	12/12/2022	23/07/2021	NEw Clinical End-points in patients with primary Sjögren’s Syndrome (pSS): an Interventional Trial b ...	NEw Clinical End-points in patients with primary Sjögren’s Syndrome (pSS): an Interventional Trial b ...	Primary Sjögren’s syndrome (pSS) MedDRA version: 21.0;Level: PT;Classification code 10040767;Term: S ...	Trade Name: PLAQUENIL Product Name: Hydroxychloroquine INN or Proposed INN: Hydroxychloroquine Other de ...	ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ( AP-HP)	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	300	Phase 2	Netherlands;Italy
2	ChiCTR2200057578	2022-03-01	2022-03-15	Tofacitinib treatment in patients with primary Sjogren syndrome: a prospective pilot trial	Tofacitinib treatment in patients with primary Sjogren syndrome: a prospective pilot trial	Sjogren Syndrome	Control group:Same dose of hydroxychloroquine sulfateas before;Intervention group:Tofacitinib 5mg bi ...	Ningbo Medical Center Lihuili Hospital	NULL	Pending	15	70	Both	Control group:60;Intervention group:60;	Phase 4	China
3	EUCTR2019-002470-32-NO (EUCTR)	14/12/2021	26/08/2021	NEw Clinical End-points in patients with primary Sjögren’s Syndrome (pSS): an Interventional Trial b ...	NEw Clinical End-points in patients with primary Sjögren’s Syndrome (pSS): an Interventional Trial b ...	Primary Sjögren’s syndrome (pSS) MedDRA version: 21.0;Level: PT;Classification code 10040767;Term: S ...	Trade Name: PLAQUENIL Product Name: Hydroxychloroquine INN or Proposed INN: Hydroxychloroquine Other de ...	ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ( AP-HP)	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	300	Phase 2	Netherlands;Norway;Italy
4	EUCTR2019-002470-32-IT (EUCTR)	05/10/2021	27/01/2022	Nuovi end-points clinici in pazienti con sindrome di Sjögren primaria (pSS): uno studio interventist ...	NEw Clinical End-points in patients with primary Sjögren's Syndrome (pSS): an Interventional Trial b ...	Primary Sjögren's syndrome (pSS) MedDRA version: 21.0;Level: PT;Classification code 10040767;Term: S ...	Trade Name: Arava Product Name: Leflunomide Product Code: [Leflunomide] INN or Proposed INN: LEFLUNOMID ...	ASSITANCE PUBLIQUE DES HOPITAUX DE PARIS	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	300	Phase 2	France;Greece;Spain;Norway;Netherlands;United Kingdom;Italy;Sweden
5	ITMCTR2000003900	2020-09-08	2020-09-08	Bushen Qingre Runzao decoction for primary Sjogren's syndrome: a randomized controlled trial	Bushen Qingre Runzao decoction for primary Sjogren's syndrome: a randomized controlled trial	Primary Sjogren's syndrome	Control group:Hydroxychloroquine sulfatetablets 200ml bid po;Experimental group:Bushen Qingre Runzao ...	China-Japan Friendship Hospital	NULL	Recruiting	18	75	Both	Control group:48;Experimental group:48;	N/A	China
6	ChiCTR2000037989	2020-09-08	2020-09-08	Bushen Qingre Runzao decoction for primary Sjogren's syndrome: a randomized controlled trial	Bushen Qingre Runzao decoction for primary Sjogren's syndrome: a randomized controlled trial	Primary Sjogren's syndrome	Experimental group:Bushen Qingre Runzao Decoction 200ml bid po;Control group:Hydroxychloroquine sulf ...	China-Japan Friendship Hospital	NULL	Recruiting	18	75	Both	Experimental group:48;Control group:48;	N/A	China

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66. IgA腎症

臨床試験数 : 275 / 薬物数 : 258 - (DrugBank : 82) / 標的遺伝子数 : 36 - 標的パスウェイ数 : 140

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02942381 (ClinicalTrials.gov)	September 13, 2016	14/10/2016	A Study of Hydroxychloroquine Sulfate for Reduction of Proteinuria in Patients With IgA Nephropathy		IgA Patients;Hydroxychloroquine	Drug: Hydroxychloroquine Sulfate;Drug: Placebo	Peking University First Hospital	NULL	Completed	18 Years	75 Years	All	60	Phase 2	China
2	NCT02765594 (ClinicalTrials.gov)	June 2016	30/4/2016	Hydroxychloroquine Sulfate Alleviates Persistent Proteinuria in IgA Nephropathy	Hydroxychloroquine SulfateAlleviates Persistent Proteinuria in IgA Nephropathy:a Single Center Prosp ...	Primary IgA Nephropathy	Drug: Hydroxychloroquine Sulfate;Drug: Valsartan	Peking Union Medical College Hospital	NULL	Recruiting	18 Years	60 Years	All	98	Phase 4	China
3	NCT02351752 (ClinicalTrials.gov)	January 2015	27/1/2015	Hydroxychloroquine Sulfatefor Reduction of Proteinuria in Patients With IgA Nephropathy: a Self- Con ...	Renal Division, Peking University First Hospital, Institute of Nephrology, Peking University, Key La ...	Primary IgA Nephropathy	Drug: Hydroxychloroquine Sulfate	LLiu	NULL	Completed	18 Years	75 Years	Both	20	Phase 4	China

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