AMILORIDE ( DrugBank: Amiloride )

4 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
13	多発性硬化症／視神経脊髄炎	5
67	多発性嚢胞腎	2
225	先天性腎性尿崩症	3
299	嚢胞性線維症	3

13. 多発性硬化症／視神経脊髄炎

臨床試験数 : 3,340 / 薬物数 : 2,163 - (DrugBank : 383) / 標的遺伝子数 : 241 - 標的パスウェイ数 : 238

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01910259 (ClinicalTrials.gov)	December 18, 2014	19/7/2013	MS-SMART: Multiple Sclerosis-Secondary Progressive Multi-Arm Randomisation Trial	A Multi-arm Phase IIB Randomised, Double Blind Placebo-controlled Clinical Trial Comparing the Effic ...	Secondary Progressive Multiple Sclerosis	Drug: Amiloride;Drug: Riluzole;Drug: Fluoxetine;Drug: Placebo	University College, London	Medical Research Council;National Institute for Health Research, United Kingdom;MS Society;Universit ...	Completed	25 Years	65 Years	All	445	Phase 2	United Kingdom
2	EUCTR2012-005394-31-GB (EUCTR)	01/04/2014	05/09/2014	MS-SMART: A Trial of Efficacy (usefulness) of 3 Neuroprotective Drugs in SPMS	MS-SMART: A Multi-Arm Phase IIb Randomised, Double Blind Placebo-Controlled Clinical Trial Comparing ...	Mutliple Sclerosis (Secondary Progressive);Therapeutic area: Diseases [C] - Nervous System Diseases ...	Trade Name: Rilutek Product Name: Rilutek INN or Proposed INN: Riluzole Trade Name: Amiloride Product Na ...	UCL	NULL	Not Recruiting			Female: yes Male: yes	440	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	United Kingdom
3	EUCTR2012-005113-39-AT (EUCTR)	08/04/2013	18/02/2013	Amiloride Hydrochlorothiazide as Treatment of Acute Inflammation of the Optic Nerve.	A Randomized, Placebo-Controlled, Double-Blind, Phase IIa Study of Amiloridein the Treatment of Acut ...	Optic neuritis is among the most common first symptoms of multiple sclerosis leading to significant ...	Trade Name: Amilostad HCT Product Name: Amilostad HCT tablets INN or Proposed INN: AMILORIDEHYDROCHLOR ...	Universitätsklinik für Neurologie, Medizinische Universität Wien	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes		Phase 2	Austria
4	NCT01802489 (ClinicalTrials.gov)	February 2013	27/2/2013	Amiloride Clinical Trial In Optic Neuritis	A Double Blind Randomised Control Trial on Neuroprotection of Amiloride in Optic Neuritis	Optic Neuritis;Multiple Sclerosis	Drug: Amiloride;Drug: Placebo	University of Oxford	Multiple Sclerosis Society of Great Britain and Northern Ireland	Completed	18 Years	55 Years	All	46	Phase 2	United Kingdom
5	EUCTR2007-004051-11-GB (EUCTR)	18/12/2008	15/07/2008	Amiloride Treatment in Multiple Sclerosis - Amiloride in MS	Amiloride Treatment in Multiple Sclerosis - Amiloride in MS	Multiple Sclerosis	Trade Name: Amiloride Product Name: Amiloride Hydrochloride	Oxford Racliffe NHS Trust	NULL	Not Recruiting			Female: yes Male: yes	23		United Kingdom

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67. 多発性嚢胞腎

臨床試験数 : 221 / 薬物数 : 212 - (DrugBank : 55) / 標的遺伝子数 : 40 - 標的パスウェイ数 : 151

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05228574 (ClinicalTrials.gov)	March 11, 2022	12/1/2022	Treatment of Vascular Stiffness in ADPKD	Treatment of Vascular Stiffness in Patients With Autosomal Dominant Polycystic Kidney Disease	Autosomal Dominant Polycystic Kidney	Dietary Supplement: Sodium chloride (NaCl);Dietary Supplement: Placebo;Drug: Amiloride Hcl 5mg Tab	Erasmus Medical Center	NULL	Recruiting	18 Years	N/A	All	54	Phase 4	Netherlands
2	EUCTR2020-000433-40-NL (EUCTR)	30/12/2021	03/08/2021	Treatment of stiffness in blood vessels in patients with familial cystic kidney disease	Treatment of vascular stiffness in patients with autosomal dominant polycystic kidney disease - TRAM ...	Autosomal dominant polycystic kidney disease;Therapeutic area: Not possible to specify	Trade Name: Amiloride Product Name: Amiloride INN or Proposed INN: AMILORIDE Trade Name: Sodium Chlorid ...	Erasmus University Medical Centre Rotterdam	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	54	Phase 4	Netherlands

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225. 先天性腎性尿崩症

臨床試験数 : 15 / 薬物数 : 48 - (DrugBank : 18) / 標的遺伝子数 : 31 - 標的パスウェイ数 : 65

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05044611 (ClinicalTrials.gov)	January 11, 2023	27/8/2021	AMIloridefor the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Trea ...	AMIloridefor the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Trea ...	Bipolar Disorder	Drug: Anhydrous Amiloride Hydrochloride;Drug: Placebo	Assistance Publique - Hôpitaux de Paris	NULL	Recruiting	18 Years	70 Years	All	148	Phase 4	France
2	NCT00478335 (ClinicalTrials.gov)	May 2007	23/5/2007	Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus	Pharmacologic Treatment of Congenital Nephrogenic Diabetes Insipidus	Nephrogenic Diabetes Insipidus	Drug: sildenafil;Drug: calcitonin;Drug: hydrochlorothiazide/amiloride;Drug: indomethacin;Drug: Place ...	University of Colorado, Denver	University of Aarhus	Completed	5 Years	25 Years	Male	4	N/A	United States;Denmark
3	EUCTR2006-001202-84-NL (EUCTR)	01/02/2007	31/01/2007	Comparison of the action of amilorideand thiazide in the reduction of lithium-NDI in patients with a ...	Comparison of the action of amilorideand thiazide in the reduction of lithium-NDI in patients with a ...	Lithium-induced Nephrogenic Diabetes Insipidus MedDRA version: 9.1;Level: LLT;Classification code 10 ...	Trade Name: Midamor Product Name: Amiloride Trade Name: Hydrochloorthiazide Product Name: hydrochloorth ...	Radboud University Nijmegen Medical Centre	NULL	Not Recruiting			Female: yes Male: yes	50	Phase 4	Netherlands

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299. 嚢胞性線維症

臨床試験数 : 1,695 / 薬物数 : 1,527 - (DrugBank : 268) / 標的遺伝子数 : 111 - 標的パスウェイ数 : 174

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00547053 (ClinicalTrials.gov)	December 2006	17/10/2007	AmilorideSolution and Tobramycin Solution for Inhalation for the Eradication of Burkholderia Dolosa ...	A Six Month Open Label Study of AmilorideSolution for Inhalation and Tobramycin Solution for Inhalat ...	Cystic Fibrosis	Drug: Amiloride Solution for Inhalation	Children's Hospital Boston	Cystic Fibrosis Foundation Therapeutics	Completed	6 Years	N/A	Both	25	Phase 1	United States
2	NCT00274391 (ClinicalTrials.gov)	July 2001	9/1/2006	Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis	Efficacy of Amiloride and Hypertonic Saline in Cystic Fibrosis	Cystic Fibrosis	Drug: 7% NaCl;Drug: Amiloride HCl	University of North Carolina	Cystic Fibrosis Foundation Therapeutics	Completed	14 Years	N/A	Both	24	Phase 2	United States
3	NCT00004705 (ClinicalTrials.gov)	September 1996	24/2/2000	Study of Uridine Triphosphate (UTP) as an Aerosol Spray for Cystic Fibrosis		Cystic Fibrosis	Drug: amiloride;Drug: uridine	FDA Office of Orphan Products Development	University of North Carolina	Completed	4 Years	N/A	Both		N/A	NULL

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