Metoprolol ( DrugBank: Metoprolol )

6 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
17	多系統萎縮症	1
57	特発性拡張型心筋症	2
58	肥大型心筋症	4
113	筋ジストロフィー	3
193	プラダー・ウィリ症候群	4
226	間質性膀胱炎（ハンナ型）	1

17. 多系統萎縮症

臨床試験数 : 119 / 薬物数 : 138 - (DrugBank : 44) / 標的遺伝子数 : 59 - 標的パスウェイ数 : 111

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01044693 (ClinicalTrials.gov)	January 2010	6/1/2010	Nebivolol in the Supine Hypertension of Autonomic Failure	Effect of Nebivolol on Blood Pressure in a Model of Hypertension Sensitive to Potentiation of Nitric ...	Hypertension;Pure Autonomic Failure;Multiple System Atrophy	Drug: Placebo;Drug: Nebivolol 5 mg;Drug: metoprolol tartrate 50 mg;Drug: Sildenafil25 mg	Vanderbilt University	Forest Laboratories	Completed	18 Years	80 Years	All	20	N/A	United States

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57. 特発性拡張型心筋症

臨床試験数 : 11 / 薬物数 : 23 - (DrugBank : 12) / 標的遺伝子数 : 9 - 標的パスウェイ数 : 35

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01917149 (ClinicalTrials.gov)	March 2005	30/7/2013	Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy	Efficacy and Safety Study of Supramaximal Titrated Inhibition of RAAS in Idiopathic Dilated Cardiomy ...	Dilated Cardiomyopathy	Drug: Benazepril;Drug: Valsartan;Drug: Metoprolol	Xijing Hospital	NULL	Completed	18 Years	70 Years	Both	480	Phase 4	China
2	NCT01798992 (ClinicalTrials.gov)	September 2000	22/2/2013	Effect of Beta-blockers on Structural Remodeling and Gene Expression in the Failing Human Heart	Beta-blocker Effect on Structural Remodeling and Gene Expression in the Failing Human Heart	Idiopathic Dilated Cardiomyopathy	Drug: Carvedilol;Drug: Metoprolol succinate;Drug: Metoprolol succinate + doxazosin	University of Colorado, Denver	National Heart, Lung, and Blood Institute (NHLBI);GlaxoSmithKline;AstraZeneca	Completed	18 Years	N/A	All	56	Phase 4	United States

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58. 肥大型心筋症

臨床試験数 : 126 / 薬物数 : 135 - (DrugBank : 42) / 標的遺伝子数 : 46 - 標的パスウェイ数 : 162

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04133532 (ClinicalTrials.gov)	March 5, 2020	16/10/2019	Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy	Effect of Metoprolol in Post Alcohol Septal Ablation Patients With Hypertrophic Cardiomyopathy	Hypertrophic Cardiomyopathy	Drug: Metoprolol	University Hospital, Motol	NULL	Recruiting	18 Years	75 Years	All	50	Phase 4	Czechia
2	ChiCTR-IIR-17013661	2018-10-10	2017-12-03	Effect of beta-blockers combined with angiotensin II receptor blockers in regression of cardiac hype ...	Effect of beta-blockers combined with angiotensin II receptor blockers in regression of cardiac hype ...	Hypertrophic cardiomyopathy	Experimental group:MetoprololSuccinate Sustained-release Tablets combined with candesartan treatment ...	The First Affiliated Hospital, Sun Yat-sen University	NULL	Recruiting	18	65	Both	Experimental group:130;Control group:130;	4 (Phase 4 study)	China
3	NCT03532802 (ClinicalTrials.gov)	May 1, 2018	19/4/2018	The Effect of Metoprolol in Patients With Hypertrophic Obstructive Cardiomyopathy.	The Effect of Metoprololon Myocardial Function, Perfusion, Hemodynamics and Heart Failure Symptoms i ...	Hypertrophic Cardiomyopathy	Drug: Metoprolol Succinate;Drug: Placebo oral capsule	Steen Hvitfeldt Poulsen	NULL	Completed	18 Years	N/A	All	30	Phase 2	Denmark
4	EUCTR2017-004478-32-DK (EUCTR)	10/01/2018	14/12/2017	The effect of metoprolol in hypertrophic obstructive cardiomyopathy	The effect of metoprololon myocardial function, hemodynamics and heart failure symptoms in patients ...	Hypertrophic obstructive cardiomyopathy MedDRA version: 20.0;Level: LLT;Classification code 10020876 ...	Trade Name: Metoprololsuccinat INN or Proposed INN: metoprololsuccinat Other descriptive name: METOPRO ...	Aarhus University Hospital	NULL	Not Recruiting			Female: yes Male: yes	32	Phase 2	Denmark

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113. 筋ジストロフィー

臨床試験数 : 646 / 薬物数 : 471 - (DrugBank : 105) / 標的遺伝子数 : 59 - 標的パスウェイ数 : 170

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2020-004901-29-PL (EUCTR)	01/06/2021	20/01/2021	MetoprololSafety and Efficacy in the Prevention of Cardiomyopathy in Patients with Duchenne Muscular ...	The efficacy and safety of Metoprololas add-on treatment to standard of care in preventing cardiomyo ...	Duchenne muscular dystrophyCardiomyopathyTachycardia MedDRA version: 20.0;Level: PT;Classification c ...	Trade Name: Betaloc ZOK 25, 23,75 mg INN or Proposed INN: Metoprolol Other descriptive name: METOPROLO ...	Medical University of Gdansk	NULL	Authorised-recruitment may be ongoing or finished			Female: no Male: yes	144	Phase 3	Poland
2	ChiCTR2000032525	2020-05-01	2020-05-01	Early intervention for subclinical myocardial prevention of ACEI and beta-blocker in patients with D ...	Early intervention for subclinical myocardial prevention of ACEI and beta-blocker in patients with D ...	Duchenne muscular dystrophy	Group A:Perindopril;Group B:metoprolol;Group C:Perindopril and metoprolol;	West China Second University Hospital, Sichuan University	NULL	Recruiting	1	18	Male	Group A:106;Group B:106;Group C:106;	Phase 4	China
3	EUCTR2009-009871-36-DE (EUCTR)		06/08/2009	Study within children with Duchenne Muscular Dystrophy	Effect and Safety of preventive Treatment with ACE-Inhibitor and Beta-Blocker on the onset of Left V ...	Therapeutic area: Diseases [C] - Musculoskeletal Diseases [C05]	Trade Name: EnalHexal®, 5 mg INN or Proposed INN: ENALAPRIL Trade Name: EnaHexal®, 10mg INN or Proposed ...	Friedrich- Alexander- Universität Erlangen Nürnberg	NULL	Not Recruiting			Female: no Male: yes			Germany

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193. プラダー・ウィリ症候群

臨床試験数 : 113 / 薬物数 : 111 - (DrugBank : 26) / 標的遺伝子数 : 48 - 標的パスウェイ数 : 102

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2021-000127-12-SE (EUCTR)	03/01/2022	08/11/2021	A 16-week phase 2b, double-blind, placebo-controlled, Multi center, dose finding safety and efficacy ...	A Phase 2b, Double-blind, Randomized, Placebo-controlled, Multi center, 16-week Dose finding, Safety ...	Prader-Willi Syndrome MedDRA version: 20.0;Level: PT;Classification code 10036476;Term: Prader-Willi ...	Product Name: Tesomet INN or Proposed INN: Tesofensine Other descriptive name: TESOFENSINE CITRATE INN ...	Saniona A/S	NULL	Not Recruiting			Female: yes Male: yes	120	Phase 2	France;United States;Spain;Belgium;Ireland;Australia;United Kingdom;New Zealand;Italy;Sweden
2	NCT03149445 (ClinicalTrials.gov)	March 30, 2017	3/4/2017	Co-administration of Tesofensine/Metoprolol in Subjects With Prader-Willi Syndrome (PWS)	A Double-blind, Randomized, Placebo-controlled, Multiple-dose, Multi-centre Safety and Efficacy Stud ...	Confirmed Genetic Diagnosis of Prader-Willi Syndrome	Drug: Tesofensine/Metoprolol;Drug: Placebos	Saniona	NULL	Completed	18 Years	30 Years	All	18	Phase 2	Czechia
3	EUCTR2016-003694-18-CZ (EUCTR)	18/01/2017	04/10/2016	Safety and efficacy of tesofensine/metoprolol in subjects with Prader-Willi syndrome	A double-blind, randomized, placebo-controlled, multiple-dose, multi-centre safety and efficacy stud ...	Prader Willi syndrome (PWS) MedDRA version: 20.0;Level: PT;Classification code 10036476;Term: Prader ...	Product Name: Tesofensine INN or Proposed INN: Tesofensine Other descriptive name: TESOFENSINE Trade Na ...	Saniona A/S	NULL	Not Recruiting			Female: yes Male: yes	35	Phase 2	Hungary;Czech Republic
4	EUCTR2016-003694-18-HU (EUCTR)	22/12/2016	13/10/2016	Safety and efficacy of tesofensine/metoprolol in subjects with Prader-Willi syndrome	A double-blind, randomized, placebo-controlled, multiple-dose, multi-centre safety and efficacy stud ...	Prader Willi syndrome (PWS) MedDRA version: 20.0;Level: PT;Classification code 10036476;Term: Prader ...	Product Name: Tesofensine INN or Proposed INN: Tesofensine Other descriptive name: TESOFENSINE INN or P ...	Saniona A/S	NULL	Not Recruiting			Female: yes Male: yes	35	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): yes Therapeutic confirmatory - ( ...	Czech Republic;Hungary

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226. 間質性膀胱炎（ハンナ型）

臨床試験数 : 145 / 薬物数 : 156 - (DrugBank : 51) / 標的遺伝子数 : 64 - 標的パスウェイ数 : 146

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03008382 (ClinicalTrials.gov)	March 1, 2017	28/12/2016	Interstitial Cystitis: Examination of the Central Autonomic Network	Interstitial Cystitis: Examination of the Central Autonomic Network	Interstitial Cystitis/Painful Bladder Syndrome;Myofascial Pelvic Pain	Drug: Metoprolol Tartrate Oral Tablet;Drug: Placebo Oral Tablet	Medical College of Wisconsin	NorthShore University HealthSystem;Case Western Reserve University	Completed	18 Years	80 Years	Female	80	Phase 4	United States

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