Ritonavir ( DrugBank: Ritonavir )

3 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
2	筋萎縮性側索硬化症	1
86	肺動脈性肺高血圧症	2
265	脂肪萎縮症	10

2. 筋萎縮性側索硬化症

臨床試験数 : 645 / 薬物数 : 589 - (DrugBank : 163) / 標的遺伝子数 : 150 - 標的パスウェイ数 : 225

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02437110 (ClinicalTrials.gov)	April 1, 2019	5/5/2015	HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (AL ...	HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (AL ...	Amyotrophic Lateral Sclerosis	Drug: Darunavir;Drug: Ritonavir;Drug: Dolutegravir;Drug: Tenofovir alafenamide (TAF)	National Institute of Neurological Disorders and Stroke (NINDS)	NULL	Active, not recruiting	18 Years	N/A	All	122	Phase 1	United States

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86. 肺動脈性肺高血圧症

臨床試験数 : 1,205 / 薬物数 : 684 - (DrugBank : 124) / 標的遺伝子数 : 100 - 標的パスウェイ数 : 193

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02023450 (ClinicalTrials.gov)	December 2013	23/12/2013	Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamic ...		Pulmonary Arterial Hypertension	Drug: saquinavir and ritonavir	The Third Xiangya Hospital of Central South University	Xiangya Hospital of Central South University	Recruiting	18 Years	60 Years	Both	20	Phase 0	China
2	NCT01251848 (ClinicalTrials.gov)	January 2011	1/12/2010	Drug Interaction Between Ritonavir And Sitaxsentan	A Phase 1, Open Label, Randomized, Multiple Dose Study To Assess The Two-Way Drug Interaction Betwee ...	Pulmonary Arterial Hypertension	Drug: Sitaxentan;Drug: Ritonavir;Drug: Sitaxsentan	Pfizer	NULL	Withdrawn	21 Years	55 Years	Both	0	Phase 1	NULL

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265. 脂肪萎縮症

臨床試験数 : 112 / 薬物数 : 155 - (DrugBank : 55) / 標的遺伝子数 : 25 - 標的パスウェイ数 : 97

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00865007 (ClinicalTrials.gov)	December 2008	18/3/2009	Lopinavir/r Monotherapy Versus Abacavir/Lamivudine and Lopinavir/r for Limb Fat Recovery in Persons ...	A Phase IV-III Comparative, Randomized, Open-label Study to Evaluate the Efficacy for the Recovery o ...	HIV Infection;Lipodystrophy;HIV Infections	Drug: Monotherapy (Lopinavir/ritonavir);Drug: Monotherapy (Lopinavir/ritonavir) + ABC/3TC	Fundacion SEIMC-GESIDA	Abbott	Completed	18 Years	N/A	Both	88	Phase 4	Spain
2	NCT00426296 (ClinicalTrials.gov)	August 2006	23/1/2007	SHARE: Simple HAART With Abacavir, Reyataz, and Epivir	An Open-Label, Multicenter Study to Evaluate the Efficacy and Safety of a Fixed-Dose Combination of ...	HIV Infections;Lipodystrophy	Drug: atazanavir (Reyataz);Drug: ritonavir (Norvir)	Clinical Alliance for Research & Education - Infectious Diseases, LLC.	GlaxoSmithKline	Recruiting	18 Years	N/A	Both		Phase 4	United States
3	EUCTR2004-002740-10-DE (EUCTR)	07/11/2005	04/10/2005	A PHASE IV, OPEN-LABEL, RANDOMIZED, MULTICENTER TRIAL ASSESSING A REYATAZ-BASED SUBSTITUTION APPROAC ...	A PHASE IV, OPEN-LABEL, RANDOMIZED, MULTICENTER TRIAL ASSESSING A REYATAZ-BASED SUBSTITUTION APPROAC ...	HIV-infected individuals with lipodystrophy	Trade Name: Reyataz Product Name: Reyataz Product Code: BMS-232632 INN or Proposed INN: Atazanavir Other ...	Bristol-Myers Squibb International Corporation	NULL	Not Recruiting			Female: yes Male: yes	300	Phase 4	United Kingdom;Germany;Spain;Italy
4	NCT00135356 (ClinicalTrials.gov)	July 2005	25/8/2005	Study of Reyataz in HIV-infected Patients With Lipodystrophy Syndrome	A Phase IV, Open-Label, Randomized, Multicenter Trial Assessing a Reyataz-Based Substitution Approac ...	HIV-Associated Lipodystrophy Syndrome	Drug: Atazanavir (ATV) + ritonavir(RTV), continuation of backbone 2 nucleoside reverse transcriptase ...	Bristol-Myers Squibb	NULL	Completed	18 Years	N/A	All	219	Phase 4	United States;Canada;France;Germany;Italy;Mexico;Poland;Spain;United Kingdom;Netherlands
5	EUCTR2004-002740-10-ES (EUCTR)	16/05/2005	17/05/2006	A PHASE IV, OPEN-LABEL, RANDOMIZED, MULTICENTER TRIAL ASSESSING A REYATAZ-BASED SUBSTITUTION APPROAC ...	A PHASE IV, OPEN-LABEL, RANDOMIZED, MULTICENTER TRIAL ASSESSING A REYATAZ-BASED SUBSTITUTION APPROAC ...	HIV-infected individuals with lipodystrophy	Trade Name: Reyataz Product Name: Reyataz Product Code: BMS-232632 INN or Proposed INN: Atazanavir Other ...	Bristol-Myers Squibb International Corporation	NULL	Not Recruiting			Female: yes Male: yes	300	Phase 4	Germany;United Kingdom;Spain;Italy
6	EUCTR2004-002740-10-GB (EUCTR)	12/05/2005	19/04/2005	A PHASE IV, OPEN-LABEL, RANDOMIZED, MULTICENTER TRIAL ASSESSING A REYATAZ-BASED SUBSTITUTION APPROAC ...	A PHASE IV, OPEN-LABEL, RANDOMIZED, MULTICENTER TRIAL ASSESSING A REYATAZ-BASED SUBSTITUTION APPROAC ...	HIV-infected individuals with lipodystrophy	Trade Name: Reyataz Product Name: Reyataz Product Code: BMS-232632 INN or Proposed INN: Atazanavir Other ...	Bristol-Myers Squibb International Corporation	NULL	Not Recruiting			Female: yes Male: yes	300	Phase 4	Spain;Germany;Italy;United Kingdom
7	NCT00139178 (ClinicalTrials.gov)	March 2004	30/8/2005	Switching From Zidovudine to an NNRTI or Lopinavir/Ritonavirin Patients Treated With Zidovudine/ Lam ...	Switching From Zidovudine to an NNRTI or Lopinavir/Ritonavirin Patients Treated With Zidovudine/ Lam ...	HIV Associated Lipodystrophy Syndrome.;HIV;Hypercholesterolemia;Lipoatrophy	Drug: Different HAART regimens	Danish HIV Research Group	Odense University Hospital;Rigshospitalet, Denmark;Hvidovre University Hospital;Aarhus University Ho ...	Completed	18 Years	N/A	Both	100	Phase 4	Denmark
8	NCT00192660 (ClinicalTrials.gov)	February 2003	12/9/2005	HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001)	Analysis of Lipodystrophy in HIV-Infected Individuals A Prospective, Non-randomised, 48 Week Study o ...	HIV-Associated Lipodystrophy Syndrome;Cardiovascular Disease	Drug: Lamivudine;Drug: Stavudine;Drug: Didanosine;Drug: Zidovudine;Drug: Tenofovir;Drug: Abacavir;Dr ...	Kirby Institute	St Vincent's Hospital, Sydney;National Heart, Lung, and Blood Institute (NHLBI)	Completed	18 Years	N/A	Both	80	Phase 4	Australia
9	NCT00122226 (ClinicalTrials.gov)	January 2003	14/7/2005	MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS)	MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS)	HIV Infections;HIV-Associated Lipodystrophy Syndrome	Drug: Lopinavir/ritonavir + zidovudine + lamivudine;Drug: Lopinavir/ritonavir + nevirapine	VU University Medical Center	Abbott;Boehringer Ingelheim	Active, not recruiting	18 Years	70 Years	Male	50	Phase 4	Finland;Netherlands;Spain;United Kingdom
10	NCT00028314 (ClinicalTrials.gov)	March 2002	20/12/2001	Effects of Treatment Changes on Fat Wasting in the Arms and Legs of HIV Patients	A Restrictively Randomized, Open-Label, Controlled, Pilot Study of the Effect of a Thymidine Analogu ...	HIV Infections;Lipodystrophy;Wasting Disease	Drug: Abacavir sulfate;Drug: Atazanavir/Ritonavir;Drug: Lopinavir/Ritonavir;Drug: Nevirapine	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Completed	13 Years	N/A	Both	150	N/A	United States

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