Zidovudine ( DrugBank: Zidovudine )

6 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
25	進行性多巣性白質脳症	3
26	HTLV-1関連脊髄症	3
135	アイカルディ症候群	1
265	脂肪萎縮症	7
325	遺伝性自己炎症疾患	1
331	特発性多中心性キャッスルマン病	2

25. 進行性多巣性白質脳症

臨床試験数 : 26 / 薬物数 : 35 - (DrugBank : 22) / 標的遺伝子数 : 8 - 標的パスウェイ数 : 37

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00001048 (ClinicalTrials.gov)	February 1998	2/11/1999	Comparison of Anti HIV Drugs Used Alone or in Combination With Cytosine Arabinoside to Treat Progres ...	A Phase II Multicenter Study Comparing Antiretroviral Therapy Alone to Antiretroviral Therapy Plus C ...	HIV Infections;Leukoencephalopathy, Progressive Multifocal	Drug: Filgrastim;Drug: Cytarabine;Drug: Zidovudine;Drug: Zalcitabine;Drug: Didanosine	National Institute of Allergy and Infectious Diseases (NIAID)	Bristol-Myers Squibb;Upjohn	Completed	18 Years	65 Years	All	90	Phase 2	United States
2	NCT00002274 (ClinicalTrials.gov)	October 1997	2/11/1999	A Study of ddI in Patients With AIDS Who Become Sicker While Taking Zidovudine	An Open Label Study Regimen of Videx (2',3'-Dideoxyinosine, ddI) in Patients With Acquired Immunodef ...	HIV Infections;Leukoencephalopathy, Progressive Multifocal	Drug: Didanosine	Bristol-Myers Squibb	NULL	Completed	12 Years	N/A	Both		N/A	United States
3	NCT00002270 (ClinicalTrials.gov)	October 1997	2/11/1999	A Pilot Study of the Efficacy of Recombinant Alpha Interferon (IFN-A2b) and Zidovudine(AZT) in the T ...	A Pilot Study of the Efficacy of Recombinant Alpha Interferon (IFN-A2b) and Zidovudine(AZT) in the T ...	HIV Infections;Leukoencephalopathy, Progressive Multifocal	Drug: Interferon alfa-2b;Drug: Zidovudine	University of Miami	NULL	Completed	18 Years	65 Years	Both		N/A	United States

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26. HTLV-1関連脊髄症

臨床試験数 : 29 / 薬物数 : 47 - (DrugBank : 29) / 標的遺伝子数 : 34 - 標的パスウェイ数 : 119

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02655471 (ClinicalTrials.gov)	July 1, 2017	16/11/2015	Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Vir ...	Effect of Raltegravir in Patients With Myelopathy/Tropical Spastic Paraparesis Associated With Infec ...	HTLV-I Infections;Tropical Spastic Paraparesis	Drug: Raltegravir and Zidovudine	Universidad Peruana Cayetano Heredia	Merck Sharp & Dohme Corp.	Completed	18 Years	N/A	All	10	Early Phase 1	Peru
2	NCT00041327 (ClinicalTrials.gov)	October 2002	8/7/2002	Combination Chemotherapy Followed By Antiviral Therapy and Interferon Alfa in Treating Patients With ...	Phase II Trial Of Induction Therapy With EPOCH Chemotherapy And Maintenance Therapy With Combivir/In ...	Lymphoma	Biological: filgrastim;Biological: recombinant interferon alfa;Drug: Etoposide;Drug: cyclophosphamid ...	AIDS Malignancy Consortium	National Cancer Institute (NCI)	Completed	18 Years	120 Years	Both	19	Phase 2	United States
3	NCT00272480 (ClinicalTrials.gov)	November 8, 1999	4/1/2006	Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial	Zidovudine Plus Lamivudine in HTLV-I-associated Myelopathy: a Randomised Trial	HTLV-I-associated Myelopathy	Drug: Zidovudine/lamivudine;Drug: Placebos	Imperial College London	NULL	Completed	16 Years	75 Years	All	16	Phase 2/Phase 3	United Kingdom

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135. アイカルディ症候群

臨床試験数 : 1 / 薬物数 : 9 - (DrugBank : 3) / 標的遺伝子数 : 0 - 標的パスウェイ数 : 0

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2014-002710-23-FR (EUCTR)		18/06/2015	N/A	N/A - AGS	MedDRA version: 18.0;Level: PT;Classification code 10054935;Term: Aicardi's syndrome;System Organ C ...	Trade Name: Zidovudine Product Name: Zidovudine Product Code: J05A F01 INN or Proposed INN: Zidovudine O ...	ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)	NULL	Not Recruiting			Female: yes Male: yes	24	Phase 2	France

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265. 脂肪萎縮症

臨床試験数 : 112 / 薬物数 : 155 - (DrugBank : 55) / 標的遺伝子数 : 25 - 標的パスウェイ数 : 97

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00192621 (ClinicalTrials.gov)	November 2004	12/9/2005	Seronegatives and Metabolic Abnormalities Protocol 2 (SAMA002): Study to Compare the Effect of Kalet ...	A 3 Arm, Prospective Study to Compare the Effect of 6 Weeks Exposure to the Combination of Lopinavir ...	HIV Infections;Dyslipidemias;Glucose Metabolism Disorders;Metabolic Diseases;Lipodystrophy;Cardiovas ...	Drug: Combivir (zidovudine [AZT] / lamivudine [3TC]);Drug: Kaletra (lopinavir [LPVr])	Kirby Institute	St Vincent's Hospital, Sydney;National Heart, Lung, and Blood Institute (NHLBI);Garvan Institute of ...	Completed	18 Years	N/A	Both	50	Phase 4	Australia
2	NCT00139178 (ClinicalTrials.gov)	March 2004	30/8/2005	Switching From Zidovudineto an NNRTI or Lopinavir/Ritonavir in Patients Treated With Zidovudine/ Lam ...	Switching From Zidovudineto an NNRTI or Lopinavir/Ritonavir in Patients Treated With Zidovudine/ Lam ...	HIV Associated Lipodystrophy Syndrome.;HIV;Hypercholesterolemia;Lipoatrophy	Drug: Different HAART regimens	Danish HIV Research Group	Odense University Hospital;Rigshospitalet, Denmark;Hvidovre University Hospital;Aarhus University Ho ...	Completed	18 Years	N/A	Both	100	Phase 4	Denmark
3	NCT00647946 (ClinicalTrials.gov)	February 2003	27/3/2008	Study to Evaluate Changes in Limb Fat When Switching From a Thymidine Analogue	A Phase II, Open-Label, Multicentre, Randomised, Comparator Study of Substitution With Tenofovir or ...	Lipodystrophy	Drug: tenofovir DF;Drug: abacavir 300mg twice daily	Gilead Sciences	NULL	Completed	18 Years	N/A	Both	100	Phase 2	United Kingdom
4	NCT00192660 (ClinicalTrials.gov)	February 2003	12/9/2005	HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001)	Analysis of Lipodystrophy in HIV-Infected Individuals A Prospective, Non-randomised, 48 Week Study o ...	HIV-Associated Lipodystrophy Syndrome;Cardiovascular Disease	Drug: Lamivudine;Drug: Stavudine;Drug: Didanosine;Drug: Zidovudine;Drug: Tenofovir;Drug: Abacavir;Dr ...	Kirby Institute	St Vincent's Hospital, Sydney;National Heart, Lung, and Blood Institute (NHLBI)	Completed	18 Years	N/A	Both	80	Phase 4	Australia
5	NCT00122226 (ClinicalTrials.gov)	January 2003	14/7/2005	MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS)	MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS)	HIV Infections;HIV-Associated Lipodystrophy Syndrome	Drug: Lopinavir/ritonavir + zidovudine + lamivudine;Drug: Lopinavir/ritonavir + nevirapine	VU University Medical Center	Abbott;Boehringer Ingelheim	Active, not recruiting	18 Years	70 Years	Male	50	Phase 4	Finland;Netherlands;Spain;United Kingdom
6	NCT00021463 (ClinicalTrials.gov)	April 2001	14/7/2001	Changing to Nonprotease Inhibitor Treatment to Improve Side Effects	Phase II, Randomized, Open-Label Study of Switching to Protease Inhibitor-Sparing Regimens for Impro ...	HIV Infections;Lipodystrophy	Drug: Abacavir sulfate, Lamivudine and Zidovudine;Drug: Abacavir sulfate;Drug: Efavirenz;Drug: Nevir ...	National Institute of Allergy and Infectious Diseases (NIAID)	NULL	Completed	13 Years	N/A	Both	342	Phase 2	United States
7	NCT00005764 (ClinicalTrials.gov)	May 2000	30/5/2000	A Study of Increased Lactic Acid and Abnormal Fat Distribution in HIV-Positive Patients	Glaxo Wellcome Trial to Assess the Regression of Hyperlactatemia and to Evaluate the Regression of E ...	HIV Infections;Lipodystrophy	Drug: Lamivudine/Zidovudine;Drug: Abacavir sulfate;Drug: Lamivudine	Glaxo Wellcome	NULL	Completed	18 Years	N/A	Both	100	Phase 4	United States

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325. 遺伝性自己炎症疾患

臨床試験数 : 5 / 薬物数 : 11 - (DrugBank : 6) / 標的遺伝子数 : 2 - 標的パスウェイ数 : 35

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02363452 (ClinicalTrials.gov)	September 10, 2015	15/1/2015	Reverse Transcriptase Inhibitors in AGS	A Pilot Clinical Trial of Reverse Transcriptase Inhibitors in Children With Aicardi-Goutières Syndro ...	Aicardi-Goutières Syndrome (AGS)	Drug: Reverse transcriptase inhibitors: Zidovudine, Lamivudine, Abacavir	Assistance Publique - Hôpitaux de Paris	NULL	Completed	1 Month	17 Years	All	11	Phase 2	France

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331. 特発性多中心性キャッスルマン病

臨床試験数 : 33 / 薬物数 : 41 - (DrugBank : 21) / 標的遺伝子数 : 22 - 標的パスウェイ数 : 123

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01441063 (ClinicalTrials.gov)	September 13, 2011	24/9/2011	Tocilizumab for KSHV-Associated Multicentric Castleman Disease	Pilot Study of Tocilizumab in Patients With Symptomatic Kaposi Sarcoma Herpesvirus (KSHV) - Associat ...	Castleman Disease;Multicentric Castleman Disease;Giant Lymph Node Hyperplasia	Drug: Zidovudine;Drug: Tocilizumab;Drug: Valganciclovir (VGC)	National Cancer Institute (NCI)	NULL	Completed	18 Years	N/A	All	8	Phase 2	United States
2	NCT00092222 (ClinicalTrials.gov)	October 28, 2004	21/9/2004	Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Corr ...	Targeted Oncolytic Virotherapy and Natural History Study of KSHV-Associated Multicentric Castleman's ...	Lymphoproliferative Disorder;HHV-8;Malignancy;HIV	Drug: Etoposide;Drug: Interferon-alpha;Drug: Rituximab;Drug: Zidovudine;Drug: Liposomal Doxorubicin; ...	National Cancer Institute (NCI)	NULL	Active, not recruiting	18 Years	N/A	All	75	Phase 2	United States

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