Human Heterologous Liver Cells ( DrugBank: - )


1 disease
告示番号疾患名(ページ内リンク)臨床試験数
251尿素サイクル異常症3

251. 尿素サイクル異常症


臨床試験数 : 54 薬物数 : 61 - (DrugBank : 15) / 標的遺伝子数 : 3 - 標的パスウェイ数 : 28
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1NCT00718627
(ClinicalTrials.gov)
July 200816/7/2008Human Heterologous Liver Cells for Infusion in Children With Urea Cycle DisordersOpen, Prospective, Uncontrolled, Multicentre Study to Evaluate The Safety and Efficacy of Multiple Applications of Liver Cell Suspension Into The Portal Vein in Children With Urea Cycle Disorders (UCDs)Urea Cycle Disorders;Carbamoylphosphate Synthetase I Deficiency;Ornithine Transcarbamylase Deficiency;CitrullinemiaBiological: Human Heterologous Liver CellsCytonet GmbH & Co. KGNULLCompletedN/A5 YearsBoth12Phase 2Germany
2EUCTR2006-000136-27-DE
(EUCTR)
17/03/200804/09/2007Open, Prospective, Uncontrolled, Multicentre Study to Evaluate The Safety and Efficacy of Multiple Applications of Liver Cell Suspension Into The Portal Vein in Children with Urea Cycle Disorders (UCDs)Open, Prospective, Uncontrolled, Multicentre Study to Evaluate The Safety and Efficacy of Multiple Applications of Liver Cell Suspension Into The Portal Vein in Children with Urea Cycle Disorders (UCDs) Neonates and Infants up to 3 months including with prenatally or postnatally confirmed urea cycle disorder with below listed deficiency and children aged > 3 months up to 5 years including with confirmed urea cycle disorder and unstable metabolism with deficiency of either: - Carbamyl-phosphate Synthetase I Deficiency (CPS1D) - Ornithine Transcarbamylase Deficiency (OTCD) - Argininosuccinate Synthetase Deficiency (ASSD/Citrullinaemia)can be included.
MedDRA version: 18.1;Level: PT;Classification code 10052450;Term: Ornithine transcarbamoylase deficiency;System Organ Class: 10010331 - Congenital, familial and genetic disorders
MedDRA version: 18.1;Classification code 10058298;Term: Argininosuccinate synthetase deficiency;Classification code 10058297;Term: Carbamoyl phosphate synthetase deficiency;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Nutritional and Metabolic Diseases [C18]
Product Name: Human heterologous liver cells (for infusion)
Product Code: HHLivC
Cytonet GmbH & Co KGNULLNot RecruitingFemale: yes
Male: yes
Germany
3EUCTR2015-000988-14-Outside-EU/EEA
(EUCTR)
12/10/2016Human Heterologous Liver Cells for Infusion in Children With Urea Cycle DisordersTitle: Open, Prospective, Historic-Controlled, Multicenter Study toEvaluate the Safety and Efficacy of Infusion of Liver Cell Suspension(HHLivC) in Children with Urea Cycle Disorders Neonatal-onset type of the following urea cycle disorders(UCD):ornithine transcarbamylase deficiency (OTCD),carbamoylphosphate synthetase I deficiency (CPS1D), orargininosuccinate synthetase deficiency (ASSD orcitrullinemia);Therapeutic area: Diseases [C] - Nutritional and Metabolic Diseases [C18]Product Name: Heparesc
Product Code: HHLivC
INN or Proposed INN: not available
Other descriptive name: ALLOGENIC HUMAN HETEROLOGOUS LIVER CELLS
PROMETHERA Biosciences S.A./N.V.NULLNAFemale: yes
Male: yes
21Phase 2United States;Canada