Droxidopa ( DrugBank: Droxidopa )

5 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
5	進行性核上性麻痺	1
6	パーキンソン病	13
17	多系統萎縮症	6
169	メンケス病	1
170	オクシピタル・ホーン症候群	1

5. 進行性核上性麻痺

臨床試験数 : 89 / 薬物数 : 107 - (DrugBank : 40) / 標的遺伝子数 : 65 - 標的パスウェイ数 : 108

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03446807 (ClinicalTrials.gov)	December 2021	20/2/2018	Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism	Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism	Parkinson Disease;Multiple System Atrophy;Progressive Supranuclear Palsy	Drug: Droxidopa;Drug: Placebo Oral Tablet	Loma Linda University	H. Lundbeck A/S	Not yet recruiting	50 Years	N/A	All	32	Phase 2	United States

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6. パーキンソン病

臨床試験数 : 2,307 / 薬物数 : 2,007 - (DrugBank : 349) / 標的遺伝子数 : 188 - 標的パスウェイ数 : 199

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03446807 (ClinicalTrials.gov)	December 2021	20/2/2018	Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism	Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism	Parkinson Disease;Multiple System Atrophy;Progressive Supranuclear Palsy	Drug: Droxidopa;Drug: Placebo Oral Tablet	Loma Linda University	H. Lundbeck A/S	Not yet recruiting	50 Years	N/A	All	32	Phase 2	United States
2	NCT04510922 (ClinicalTrials.gov)	February 11, 2019	9/7/2020	Lundbeck TOMs Orthostatic Hypotension	Technology-Based Objective Measures for Gait and Postural Assessment in Parkinson Disease Patients W ...	Orthostatic Hypotension;Idiopathic Parkinson Disease	Drug: Droxidopa 100 MG [Northera]	Alberto Espay, MD, MSc	Lundbeck LLC	Completed	30 Years	80 Years	All	10	Phase 4	United States
3	NCT03229174 (ClinicalTrials.gov)	August 23, 2018	21/4/2017	Brain Perfusion & Oxygenation in Parkinson's Disease With NOH	Evaluation of Brain Perfusion and Oxygenation in PD Patients With Neurogenic Orthostatic Hypotension ...	Parkinson Disease;Neurogenic Orthostatic Hypotension	Drug: Droxidopa;Drug: Placebo	William Ondo, MD	Lundbeck LLC	Completed	18 Years	85 Years	All	17	Phase 4	United States
4	NCT03567447 (ClinicalTrials.gov)	August 17, 2018	21/5/2018	Effect of L-Dihydroxyphenylserine (L-DOPS) on Falls in Patients With Neurogenic Orthostatic Hypotens ...	Effect of L-Dihydroxyphenylserine (L-DOPS) on Falls in Patients With Neurogenic Orthostatic Hypotens ...	Parkinson Disease;Falls Patient	Drug: Droxidopa;Other: Placebo	St. Joseph's Hospital and Medical Center, Phoenix	H. Lundbeck A/S;Arizona State University	Recruiting	30 Years	83 Years	All	10	Phase 2	United States
5	NCT03115827 (ClinicalTrials.gov)	April 18, 2017	9/3/2017	Norepinephrine-targeted Therapy for Action Control in Parkinson Disease	Norepinephrine-targeted Therapy for Action Control in Parkinson Disease	Parkinson Disease	Drug: Droxidopa;Drug: Carbidopa	Vanderbilt University Medical Center	H. Lundbeck A/S;American Academy of Neurology	Completed	18 Years	N/A	All	15	Phase 4	United States
6	NCT03034564 (ClinicalTrials.gov)	January 2017	25/1/2017	A Randomized, Double-Blind, Placebo-Controlled Study of Droxidopa for Fatigue in Parkinson's Disease	A Randomized, Double-Blind, Placebo-Controlled Study of Droxidopa for Fatigue in Parkinson's Disease	Parkinson Disease;Fatigue;Parkinsonism	Drug: Northera;Drug: Placebo Oral Tablet	The Cooper Health System	NULL	Terminated	18 Years	N/A	All	1	Phase 4	United States
7	NCT02897063 (ClinicalTrials.gov)	September 2016	7/9/2016	Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure	The Effects of Midodrine and Droxidopaon Splanchnic Capacitance in Autonomic Failure Aim 2 of RDCRN ...	Autonomic Failure;Pure Autonomic Failure;Multiple System Atrophy;Parkinson Disease;Orthostatic Hypot ...	Drug: Droxidopa;Drug: Midodrine;Drug: Placebo	Vanderbilt University Medical Center	NULL	Recruiting	40 Years	80 Years	All	34	Phase 1	United States
8	NCT03173781 (ClinicalTrials.gov)	April 2016	10/8/2016	Effects of DroxidopaWhen Measuring Gait Speed, Kyphosis, and Functional Reach in Parkinson's Disease ...	Effects of DroxidopaWhen Measuring Gait Speed, Kyphosis, and Functional Reach in Parkinson's Disease ...	Parkinson's Disease	Drug: droxidopa;Drug: Placebo	Colorado Springs Neurological Associates	H. Lundbeck A/S	Completed	18 Years	N/A	All	21	N/A	United States
9	NCT02066571 (ClinicalTrials.gov)	March 2015	18/2/2014	Study to Assess the Clinical Benefit and Safety of Droxidopa in Parkinson's Disease	A Phase II, Double-Blind, Placebo-Controlled, Crossover Study to Assess Clinical Benefit and Safety ...	Parkinson's Disease;Freezing of Gait;Cognitive Ability, General	Drug: Droxidopa;Drug: sugar pill	Henry Ford Health System	NULL	Enrolling by invitation	30 Years	N/A	Both	20	Phase 2	United States
10	NCT01927055 (ClinicalTrials.gov)	November 2013	16/8/2013	A Clinical Study of Patients With Symptomatic NOH to Assess Sustained Effects of Droxidopa Therapy	A Clinical Study of Patients With Symptomatic Neurogenic Orthostatic Hypotension to Assess Sustained ...	Symptomatic Neurogenic Orthostatic Hypotension;Parkinson's Disease;Multiple Systems Atrophy;Pure Aut ...	Drug: Droxidopa;Drug: Placebo	Chelsea Therapeutics	NULL	Terminated	18 Years	N/A	All	61	Phase 3	United States

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17. 多系統萎縮症

臨床試験数 : 119 / 薬物数 : 138 - (DrugBank : 44) / 標的遺伝子数 : 59 - 標的パスウェイ数 : 111

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03446807 (ClinicalTrials.gov)	December 2021	20/2/2018	Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism	Safety and Efficacy of Droxidopa for Fatigue in Patients With Parkinsonism	Parkinson Disease;Multiple System Atrophy;Progressive Supranuclear Palsy	Drug: Droxidopa;Drug: Placebo Oral Tablet	Loma Linda University	H. Lundbeck A/S	Not yet recruiting	50 Years	N/A	All	32	Phase 2	United States
2	NCT02897063 (ClinicalTrials.gov)	September 2016	7/9/2016	Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure	The Effects of Midodrine and Droxidopaon Splanchnic Capacitance in Autonomic Failure Aim 2 of RDCRN ...	Autonomic Failure;Pure Autonomic Failure;Multiple System Atrophy;Parkinson Disease;Orthostatic Hypot ...	Drug: Droxidopa;Drug: Midodrine;Drug: Placebo	Vanderbilt University Medical Center	NULL	Recruiting	40 Years	80 Years	All	34	Phase 1	United States
3	NCT02071459 (ClinicalTrials.gov)	January 21, 2014	21/2/2014	Efficacy of L-threo DOPS on Orthostatic Hypotension Symptoms and Other Non-motor Symptoms in Patient ...	Evaluate the Long-term (3 Months) Efficacy of L-threo DOPS (DroxiDopa) on Orthostatic Hypotension Sy ...	Multiple System Atrophy	Drug: L-Threo DOPS;Drug: placebo	University Hospital, Toulouse	NULL	Completed	30 Years	80 Years	All	107	Phase 2/Phase 3	France
4	NCT00738062 (ClinicalTrials.gov)	January 2008	19/8/2008	Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)	An Open-label Study, to Assess the Long-term Safety and Clinical Benefit of Droxidopain Subjects Wit ...	Neurogenic Orthostatic Hypotension;Non-Diabetic Autonomic Neuropathy;Multiple System Atrophy;Dopamin ...	Drug: Droxidopa;Drug: Placebo	Chelsea Therapeutics	NULL	Completed	18 Years	N/A	All	103	Phase 3	United States;Australia;Canada;New Zealand
5	NCT00547911 (ClinicalTrials.gov)	October 2007	19/10/2007	Augmenting Effects of L-DOPS With Carbidopa and Entacapone	L-Dihydroxyphenylserine (L-DOPS) for Norepinephrine Deficiency: Interactions With Carbidopa and Enta ...	Parkinson Disease;Multiple System Atrophy;Autonomic Nervous System Diseases	Drug: Droxidopa;Drug: Carbidopa;Drug: Entacapone	National Institute of Neurological Disorders and Stroke (NINDS)	NULL	Terminated	18 Years	N/A	All	14	Phase 1/Phase 2	United States
6	NCT00004478 (ClinicalTrials.gov)	March 1999	18/10/1999	Droxidopa in Treating Patients With Neurogenic Hypotension	Study of Droxidopa in Patients With Neurologic Hypotension	Shy-Drager Syndrome;Orthostatic Hypotension	Drug: droxidopa	Mount Sinai School of Medicine	NULL	Completed	20 Years	N/A	Both		N/A	United States

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169. メンケス病

臨床試験数 : 6 / 薬物数 : 6 - (DrugBank : 4) / 標的遺伝子数 : 9 - 標的パスウェイ数 : 14

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04977388 (ClinicalTrials.gov)	July 12, 2021	9/7/2021	NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Occipital Horn Syndro ...	Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and A ...	Menkes Disease;Occipital Horn Syndrome	Drug: Droxidopa;Other: Placebo	Stephen G. Kaler, MD	NULL	Recruiting	18 Years	50 Years	All	6	Phase 1/Phase 2	United States

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170. オクシピタル・ホーン症候群

臨床試験数 : 2 / 薬物数 : 4 - (DrugBank : 3) / 標的遺伝子数 : 9 - 標的パスウェイ数 : 14

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04977388 (ClinicalTrials.gov)	July 12, 2021	9/7/2021	NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and Occipital Horn Syndro ...	Phase I/II Study of NORTHERA (DROXIDOPA) for Dysautonomia in Adult Survivors of Menkes Disease and A ...	Menkes Disease;Occipital Horn Syndrome	Drug: Droxidopa;Other: Placebo	Stephen G. Kaler, MD	NULL	Recruiting	18 Years	50 Years	All	6	Phase 1/Phase 2	United States

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