Nitrate ( DrugBank: Nitrate )

4 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
58	肥大型心筋症	2
67	多発性嚢胞腎	1
113	筋ジストロフィー	3
299	嚢胞性線維症	4

58. 肥大型心筋症

臨床試験数 : 126 / 薬物数 : 135 - (DrugBank : 42) / 標的遺伝子数 : 46 - 標的パスウェイ数 : 162

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT03832660 (ClinicalTrials.gov)	May 3, 2019	1/2/2019	Sacubitril/Valsartan vs Lifestyle in Hypertrophic Cardiomyopathy	Clinical and Genetic Determinants of Disease Progression and Response to Sacubitril/Valsartan vs Lif ...	Hypertrophic Cardiomyopathy	Behavioral: Lifestyle;Drug: Sacubitril/Valsartan	Newcastle University	Azienda Ospedaliero-Universitaria Careggi;University Hospital Regensburg;Institute for Cardiovascula ...	Completed	18 Years	70 Years	All	168	Phase 2	Germany;Italy;Serbia;United Kingdom
2	NCT03251287 (ClinicalTrials.gov)	November 2017	11/8/2017	Nitrite in Hypertrophic Cardiomyopathy (HCM) Study	Mechanistic Study of the Effect of Inorganic Sodium Nitrateon Cardiac and Skeletal Muscle Metabolic ...	Cardiomyopathy, Hypertrophic	Drug: Sodium Nitrate;Drug: Placebo;Diagnostic Test: Phosphorous Magnetic Resonance Spectroscopy;Diag ...	University of East Anglia	Norfolk and Norwich University Hospitals NHS Foundation Trust;British Medical Research Council	Recruiting	18 Years	80 Years	All	18	Phase 1	United Kingdom

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67. 多発性嚢胞腎

臨床試験数 : 221 / 薬物数 : 212 - (DrugBank : 55) / 標的遺伝子数 : 40 - 標的パスウェイ数 : 151

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT05401409 (ClinicalTrials.gov)	May 5, 2022	27/5/2022	Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease	Double-Blind, Randomised Placebo-Controlled Study to Determine the Effect of Beetroot Juice on Reduc ...	Autosomal Dominant Polycystic Kidney;Hypertension;Endothelial Dysfunction	Dietary Supplement: Beetroot juice;Dietary Supplement: Nitrate-depleted beetroot juice	Western Sydney Local Health District	Westmead Institute for Medical Research	Recruiting	18 Years	70 Years	All	60	N/A	Australia

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113. 筋ジストロフィー

臨床試験数 : 646 / 薬物数 : 471 - (DrugBank : 105) / 標的遺伝子数 : 59 - 標的パスウェイ数 : 170

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02434627 (ClinicalTrials.gov)	June 2015	28/4/2015	Sodium Nitrate for Muscular Dystrophy	Sodium Nitrate for Muscular Dystrophy	Becker Muscular Dystrophy	Drug: Sodium Nitrate	Cedars-Sinai Medical Center	NULL	Completed	15 Years	45 Years	Male	5	Phase 1	United States
2	NCT02147639 (ClinicalTrials.gov)	October 2013	25/3/2014	Effects of Sodium Nitrate on Blood Flow in Becker Muscular Dystrophy		Becker Muscular Dystrophy	Dietary Supplement: Sodium Nitrate;Dietary Supplement: Sodium Nitrate- double dose;Dietary Supplemen ...	Cedars-Sinai Medical Center	NULL	Completed	15 Years	45 Years	Male	19	Phase 2/Phase 3	United States
3	NCT02847975 (ClinicalTrials.gov)	October 2013	30/4/2014	Sodium Nitrate to Improve Blood Flow	Sodium Nitrate to Improve Blood Flow	Becker Muscular Dystrophy	Dietary Supplement: Sodium nitrate	Cedars-Sinai Medical Center	NULL	Completed	15 Years	55 Years	Male	11	Phase 1	United States

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299. 嚢胞性線維症

臨床試験数 : 1,695 / 薬物数 : 1,527 - (DrugBank : 268) / 標的遺伝子数 : 111 - 標的パスウェイ数 : 174

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04294043 (ClinicalTrials.gov)	June 17, 2021	1/3/2020	IV Gallium Study for Patients With Cystic Fibrosis Who Have NTM (ABATE Study)	A Phase 1b, Multi-center Study of Intravenous (IV) Gallium Nitratein Patients With Cystic Fibrosis ( ...	Nontuberculous Mycobacterium Infection	Drug: Gallium nitrate	Chris Goss	Cystic Fibrosis Foundation	Recruiting	18 Years	N/A	All	40	Phase 1	United States
2	NCT02354859 (ClinicalTrials.gov)	March 2016	30/7/2014	A Phase 2 IV Gallium Study for Patients With Cystic Fibrosis (IGNITE Study)	A Phase 2, Multi-Center, Randomized, Placebo-Controlled Study of IV Gallium Nitratein Patients With ...	Cystic Fibrosis	Drug: Gallium nitrate;Drug: Normal Saline	University of Washington	Cystic Fibrosis Foundation	Completed	18 Years	N/A	All	119	Phase 2	United States
3	NCT02310789 (ClinicalTrials.gov)	July 31, 2015	3/9/2014	(Study: Vertex IIS) Does Ivacaftor Alter Wild Type CFTR-Open Probability In The Sweat Gland Secretor ...	(Study: Vertex IIS) A Study To Access the Effects of Ivacaftor on Wild Type CFTR-Open Probability (P ...	Cystic Fibrosis	Drug: Ivacaftor;Drug: ß-Adrenergic cocktail;Drug: Pilocarpine Nitrate5%;Device: Macroduct sweat stim ...	Richard Barry Moss	NULL	Completed	18 Years	N/A	All	8	N/A	United States
4	NCT01093521 (ClinicalTrials.gov)	April 2010	24/3/2010	A Pharmacokinetic and Safety Study of IV Gallium Nitrate (Ganite) in Cystic Fibrosis Patients	A Pharmacokinetic and Safety Study of IV Gallium Nitrate (Ganite) in Cystic Fibrosis Patients	Cystic Fibrosis	Drug: 100 mg/m2 dose;Drug: 200 mg/m2 dose	University of Washington	Cystic Fibrosis Foundation	Completed	18 Years	55 Years	All	20	Phase 1	United States

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