TOPIRAMATE ( DrugBank: Topiramate )

6 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
6	パーキンソン病	4
97	潰瘍性大腸炎	1
140	ドラベ症候群	2
144	レノックス・ガストー症候群	3
156	レット症候群	1
193	プラダー・ウィリ症候群	3

6. パーキンソン病

臨床試験数 : 2,307 / 薬物数 : 2,007 - (DrugBank : 349) / 標的遺伝子数 : 188 - 標的パスウェイ数 : 199

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01789047 (ClinicalTrials.gov)	March 2013	7/2/2013	Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease	Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease	Idiopathic Parkinson's Disease;Drug Induced Dyskinesia	Drug: Topiramate;Drug: Placebo;Drug: Amantadine	Rush University Medical Center	Michael J. Fox Foundation for Parkinson's Research	Terminated	30 Years	90 Years	All	42	Phase 2	United States
2	NCT00794313 (ClinicalTrials.gov)	September 2009	19/11/2008	Quantification of the Antidyskinetic Effect of Amantadine and Topiramate in Parkinson's Disease	Quantification of the Antidyskinetic Effect of Amantadine and Topiramate in Parkinson's Disease	Parkinson's Disease	Drug: Amantadine 300 mg;Drug: Topiramate;Drug: Sugar Pill	Oregon Health and Science University	NULL	Terminated	21 Years	N/A	All	3	N/A	United States
3	EUCTR2007-002467-27-GB (EUCTR)	24/01/2008	26/11/2007	Antidyskinetic Properties of Topiramate: A Double-Blind, Placebo-Controlled Trial in Patients with P ...	Antidyskinetic Properties of Topiramate: A Double-Blind, Placebo-Controlled Trial in Patients with P ...	Patients with idiopathic Parkinson's disease and levodopa-induced dyskinesias MedDRA version: 13.1;L ...	Product Name: Topiramate INN or Proposed INN: TOPIRAMATE	Salford Royal NHS Foundation Trust	NULL	Not Recruiting			Female: yes Male: yes			United Kingdom
4	NCT00296959 (ClinicalTrials.gov)	September 2004	23/2/2006	Topiramate as a Treatment for Levodopa-Induced Dyskinesia in Parkinson's Disease	Anti-Dyskinetic Properties of Topiramate: A Double-Blind, Placebo-Controlled Trial in Patients With ...	Parkinson's Disease	Drug: topiramate (drug)	University Health Network, Toronto	NULL	Terminated	30 Years	75 Years	Both	20	Phase 2	Canada

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97. 潰瘍性大腸炎

臨床試験数 : 2,630 / 薬物数 : 1,459 - (DrugBank : 265) / 標的遺伝子数 : 144 - 標的パスウェイ数 : 202

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04721873 (ClinicalTrials.gov)	December 18, 2020	19/1/2021	Pharmacologic Weight Loss as Adjunct Therapy for Ulcerative Colitis in Obese Patients	Pharmacologic Weight Loss as Adjunct Therapy for Ulcerative Colitis in Obese Patients: A Phase 2A, R ...	Colitis, Ulcerative;Obesity	Drug: Phentermine-Topiramate;Drug: Placebo	University of California, San Diego	NULL	Recruiting	18 Years	80 Years	All	40	Phase 2	United States

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140. ドラベ症候群

臨床試験数 : 116 / 薬物数 : 65 - (DrugBank : 17) / 標的遺伝子数 : 50 - 標的パスウェイ数 : 64

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	EUCTR2007-003702-95-IT (EUCTR)	03/07/2007	07/09/2007	A MULTICENTRE RANDOMIZED CONTROLLED TRIAL COMPARING TOPIRAMATE, STIRIPENTOL AND CLOBAZAM AS ADJUNCTI ...	A MULTICENTRE RANDOMIZED CONTROLLED TRIAL COMPARING TOPIRAMATE, STIRIPENTOL AND CLOBAZAM AS ADJUNCTI ...	Dravet Syndrome Level: PTClassification code 10054859	Trade Name: stiripentolo Trade Name: TOPAMAX INN or Proposed INN: Topiramate Trade Name: FRISIUM*30CPS ...	ISTITUTO C. MONDINO	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	90		Italy
2	EUCTR2007-002198-30-IT (EUCTR)	03/07/2007	17/01/2012	A MULTICENTRE RANDOMIZED CONTROLLED TRIAL COMPARING TOPIRAMATE, STIRIPENTOL AND CLOBAZAM AT THE MAXI ...	A MULTICENTRE RANDOMIZED CONTROLLED TRIAL COMPARING TOPIRAMATE, STIRIPENTOL AND CLOBAZAM AT THE MAXI ...	Dravet Syndrome MedDRA version: 14.1;Level: PT;Classification code 10054859;Term: Myoclonic epilepsy ...	Trade Name: stiripentolo INN or Proposed INN: Other antiepileptics Trade Name: TOPAMAX INN or Proposed ...	Inserm-ISP Pole Recherches cliniques et thérapeutiques	NULL	Not Recruiting			Female: yes Male: yes	90		Italy

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144. レノックス・ガストー症候群

臨床試験数 : 111 / 薬物数 : 72 - (DrugBank : 14) / 標的遺伝子数 : 49 - 標的パスウェイ数 : 61

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00297349 (ClinicalTrials.gov)	November 2003	24/2/2006	A Study of the Safety of TopiramateGiven in Combination With Other Medications in Adults and Childre ...	An Open-label Observation Study of TopiramateAdministration as Adjuvant Therapy for Focal Epilepsy, ...	Seizures;Epilepsy	Drug: Topiramate	Janssen Cilag Pharmaceutica S.A.C.I., Greece	NULL	Completed	2 Years	N/A	Both	153	N/A	NULL
2	NCT00004776 (ClinicalTrials.gov)	November 1993	24/2/2000	Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Topiramatefor Lennox-Gastaut Sy ...		Lennox-Gastaut Syndrome	Drug: topiramate	National Center for Research Resources (NCRR)	University of California, Los Angeles	Completed	4 Years	30 Years	Both	10	Phase 3	NULL
3	NCT00236756 (ClinicalTrials.gov)	August 1993	7/10/2005	A Study of the Efficacy and Safety of Topiramateas an add-on Therapy in the Treatment of Epilepsy Pa ...	A Double-Blind Trial of Topiramate in Subjects With Lennox-Gastaut Syndrome.	Epilepsy;Seizures	Drug: topiramate	Johnson & Johnson Pharmaceutical Research & Development, L.L.C.	NULL	Completed	12 Months	30 Years	Both	100	Phase 3	NULL

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156. レット症候群

臨床試験数 : 44 / 薬物数 : 61 - (DrugBank : 23) / 標的遺伝子数 : 57 - 標的パスウェイ数 : 83

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00004807 (ClinicalTrials.gov)	January 1995	24/2/2000	Study of the Pathogenesis of Rett Syndrome		Rett Syndrome	Drug: dextromethorphan;Drug: topiramate;Drug: Donepezil	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	Johns Hopkins University	Completed	N/A	45 Years	Both	120	N/A	NULL

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193. プラダー・ウィリ症候群

臨床試験数 : 113 / 薬物数 : 111 - (DrugBank : 26) / 標的遺伝子数 : 48 - 標的パスウェイ数 : 102

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No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT02810483 (ClinicalTrials.gov)	December 2012	17/5/2016	Study of the Efficacy of Topiramate in Patients With Prader Willi Syndrome Over 8 Weeks	Randomized, Placebo Controlled Double-blind Study of the Efficacy of Topiramateon the Symptoms of Ir ...	Prader-Willi Syndrome	Drug: Topiramate;Drug: Placebo Comparator	Assistance Publique - Hôpitaux de Paris	NULL	Terminated	12 Years	45 Years	All	69	Phase 3	France
2	NCT00065923 (ClinicalTrials.gov)	July 2002	1/8/2003	Treatment of Self-Injurious Behavior in Individuals With Prader-Willi Syndrome	Topiramate Effects on SIB in Prader-Willi Syndrome	Prader-Willi Syndrome;Self-Injurious Behavior	Drug: Topiramate	Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)	NULL	Completed	18 Years	66 Years	Both	10	N/A	United States
3	EUCTR2011-003432-32-FR (EUCTR)		13/10/2011	N/A	N/A - TOPRADER	MedDRA version: 14.0;Level: PT;Classification code 10036476;Term: Prader-Willi syndrome;System Orga ...	Trade Name: Topiramate Product Name: Topiramate INN or Proposed INN: topiramate	ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (AP-HP)	NULL	Not Recruiting			Female: yes Male: yes	125	Human pharmacology (Phase 1): no Therapeutic exploratory (Phase 2): no Therapeutic confirmatory - (P ...	France

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