Fexinidazole ( DrugBank: Fexinidazole )


1 disease
告示番号疾患名(ページ内リンク)臨床試験数
65原発性免疫不全症候群9

65. 原発性免疫不全症候群


臨床試験数 : 500 薬物数 : 614 - (DrugBank : 119) / 標的遺伝子数 : 92 - 標的パスウェイ数 : 217
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PhaseCountries
1NCT03974178
(ClinicalTrials.gov)
September 29, 201923/5/2019Efficacy and Safety of Fexinidazole in Patients With Human African Trypanosomiasis (HAT) Due to Trypanosoma Brucei RhodesienseEfficacy and Safety of Fexinidazole in Patients With Human African Trypanosomiasis (HAT) Due to Trypanosoma Brucei Rhodesiense: a Multicentre, Open-label Clinical TrialTrypanosoma Brucei Rhodesiense; InfectionDrug: FexinidazoleDrugs for Neglected DiseasesEuropean and Developing Countries Clinical Trials Partnership (EDCTP)Completed6 YearsN/AAll45Phase 2/Phase 3Malawi;Uganda
2NCT03025789
(ClinicalTrials.gov)
November 17, 201611/11/2016Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any StageAn Open-label Study Assessing Effectiveness, Safety and Compliance With Fexinidazole in Patients With Human African Trypanosomiasis Due to T.b. Gambiense at Any StageTrypanosomiasis, African;Sleeping Sickness;Trypanosomiasis; GambianDrug: FexinidazoleDrugs for Neglected DiseasesSanofiCompleted6 YearsN/AAll174Phase 3Congo, The Democratic Republic of the;Guinea
3NCT02571062
(ClinicalTrials.gov)
March 201524/6/2015Bioequivalence Study - Reference Clinical Fexinidazole Tablet Versus Proposed Market FormulationA Bioequivalence Study of the Reference Clinical Fexinidazole Tablet vs Proposed Market Formulation in Healthy Male Volunteers of African Sub-Saharan Origin:an Open-label,Randomized,Two-treatment,Single Dose,Replicate Design,Fed ConditionTrypanosomiasis, AfricanDrug: FexinidazoleDrugs for Neglected DiseasesNULLCompleted18 Years45 YearsMale30Phase 1France
4NCT02498782
(ClinicalTrials.gov)
July 201420/8/2014Study to Evaluate Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chagas DiseasePhase 2, Randomized, Multicenter, Placebo-controlled, Safety and Efficacy Study to Evaluate Six Oral Fexinidazole Dosing Regimens for the Treatment of Adult Patients With Chronic Indeterminate Chagas Disease.Chagas Disease;Trypanosomiasis, South American;South American Trypanosomiasis;Disease, ChagasDrug: Fexinidazole;Drug: PlaceboDrugs for Neglected DiseasesNULLRecruiting18 Years50 YearsBoth140Phase 2Bolivia
5NCT02184689
(ClinicalTrials.gov)
May 3, 201419/6/2014Efficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plug-in to the Pivotal StudyEfficacy and Safety of Fexinidazole in Children at Least 6 Years Old and Weighing Over 20 kg With Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open Study, plug-in to the Pivotal StudyHuman African Trypanosomiasis (HAT)Drug: fexinidazoleDrugs for Neglected DiseasesNULLCompleted6 Years14 YearsAll125Phase 2/Phase 3Congo, The Democratic Republic of the
6NCT02169557
(ClinicalTrials.gov)
April 30, 201415/5/2014Efficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in to the Pivotal StudyEfficacy and Safety of Fexinidazole in Patients With Stage 1 or Early Stage 2 Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: a Prospective, Multicentre, Open-label Cohort Study, plug-in to the Pivotal StudyHuman African Trypanosomiasis (HAT)Drug: FexinidazoleDrugs for Neglected DiseasesNULLCompleted15 YearsN/AAll230Phase 2/Phase 3Congo, The Democratic Republic of the
7NCT01685827
(ClinicalTrials.gov)
October 201212/9/2012Pivotal Study of Fexinidazole for Human African Trypanosomiasis in Stage 2Efficacy and Safety of Fexinidazole Compared to Nifurtimox-Eflornithine Combination Therapy (NECT) in Patients With Late-stage Human African Trypanosomiasis (HAT) Due to T.b. Gambiense: Pivotal, Non-inferiority, Multicentre, Randomised, Open-label StudyHuman African Trypanosomiasis (HAT);Sleeping SicknessDrug: Fexinidazole;Drug: Nifurtimox;Drug: EflornithineDrugs for Neglected DiseasesNULLCompleted15 YearsN/AAll394Phase 2/Phase 3Central African Republic;Congo, The Democratic Republic of the;Congo
8NCT01483170
(ClinicalTrials.gov)
September 201129/11/2011Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With FoodDouble-blind, Placebo Controlled, Randomized Multiple Ascending Dose Study in Fed Conditions for Ten Days Dosing Regimen With a Loading Dose to Evaluate the Safety, the Tolerability and the Pharmacokinetics of Oral Fexinidazole in 36 Healthy Male Sub-Saharan Volunteers.Trypanosomiasis, AfricanDrug: Tablets Fexinidazole;Drug: PlaceboDrugs for Neglected DiseasesNULLTerminated18 Years45 YearsMale30Phase 1France
9NCT00982904
(ClinicalTrials.gov)
September 200922/9/2009Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the FexinidazoleRandomized, Double-blind, Placebo-controlled Study of the Tolerability, and Pharmacokinetics of Fexinidazole After Single and Repeated Oral Ascending Doses, Completed by a Comparative Bioavailability Study of an Oral Suspension Versus a Tablet and an Exploratory Assessment of Food Effect, in Healthy Male VolunteersHuman African TrypanosomiasisDrug: Fexinidazole/PlaceboDrugs for Neglected DiseasesSanofiCompleted18 Years45 YearsMale108Phase 1France