TIRATRICOL ( DrugBank: Tiratricol )


2 diseases
告示番号疾患名(ページ内リンク)臨床試験数
78下垂体前葉機能低下症2
139先天性大脳白質形成不全症6

78. 下垂体前葉機能低下症


臨床試験数 : 492 薬物数 : 341 - (DrugBank : 47) / 標的遺伝子数 : 45 - 標的パスウェイ数 : 100
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1EUCTR2019-003370-35-IT
(EUCTR)
30/04/202024/05/2021Tiratricol treatment of children with Monocarboxylate Transporter 8 deficiency: Triac Trial IITiratricol treatment of children with Monocarboxylate Transporter 8 deficiency: Triac Trial II - Triac Trial II Monocarboxylate Transporter 8 (MCT8) deficiency
MedDRA version: 20.0;Level: PT;Classification code 10078564;Term: Thyroid stimulating hormone deficiency;System Organ Class: 10014698 - Endocrine disorders;Therapeutic area: Diseases [C] - Hormonal diseases [C19]
Product Name: emcitate
Product Code: [emcitate]
INN or Proposed INN: Tiratricol
Other descriptive name: Tiratricol
Product Name: Emcitate
Product Code: [Emcitate]
INN or Proposed INN: Tiratricol
Other descriptive name: Tiratricol
Rare Thyroid Therapeutics InternationalNULLAuthorised-recruitment may be ongoing or finishedFemale: no
Male: yes
18Phase 2France;United States;Czechia;Czech Republic;Netherlands;Germany;United Kingdom;Italy
2EUCTR2019-003370-35-GB
(EUCTR)
28/02/202007/01/2020Tiratricol treatment of children with Monocarboxylate Transporter 8 deficiency: Triac Trial IITiratricol treatment of children with Monocarboxylate Transporter 8 deficiency: Triac Trial II - Triac Trial II Monocarboxylate Transporter 8 (MCT8) deficiency
MedDRA version: 20.0;Level: PT;Classification code 10078564;Term: Thyroid stimulating hormone deficiency;System Organ Class: 10014698 - Endocrine disorders;Therapeutic area: Diseases [C] - Hormonal diseases [C19]
Product Name: Emcitate
INN or Proposed INN: TIRATRICOL
Product Name: Emcitate
INN or Proposed INN: TIRATRICOL
Rare Thyroid Therapeutics International ABNULLAuthorised-recruitment may be ongoing or finishedFemale: no
Male: yes
22Phase 2United States;France;Czech Republic;Netherlands;Germany;Italy;United Kingdom

139. 先天性大脳白質形成不全症


臨床試験数 : 10 薬物数 : 7 - (DrugBank : 2) / 標的遺伝子数 : 2 - 標的パスウェイ数 : 2
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT02396459
(ClinicalTrials.gov)
December 7, 20207/3/2015Triac Trial II in MCT8 Deficiency PatientsTiratricol Treatment of Children With Monocarboxylate Transporter 8 Deficiency: Triac Trial IIAllan-Herndon-Dudley SyndromeDrug: TriacRare Thyroid Therapeutics International ABErasmus Medical CenterActive, not recruitingN/A30 MonthsMale22Phase 2United States;Czechia;Germany;Netherlands
2EUCTR2014-000178-20-CZ
(EUCTR)
04/02/201623/06/2015Therapy of MCT8 patients with the thyroid hormone analog Triac.Thyroid hormone analog therapy of patients with severe psychomotor retardation caused by mutations in the MCT8 thyroid hormone transporter: The Triac Trial. - Triac Trial in MCT8 patients This therapuetical trial will be conducted in patient with the Allan-Herndon-Dudley Syndrome (AHDS), casued by mutations in the thyroid hormone transporter MCT8. This results in the characteristic clinical phenotype of severe psychomotor retardation due to local hypothyroidism in the brain, in combination with high serum T3 and high normal serum TSH levels that lead to local hyperthyroidism in tissues that do not dependent on MCT8, resulting in tachycardia, low body weight and muscle wasting.;Therapeutic area: Diseases [C] - Hormonal diseases [C19]Trade Name: Téatrois (Tiratricol)
Product Name: Téatrois
Erasmus Medical CentreNULLAuthorised-recruitment may be ongoing or finishedFemale: no
Male: yes
40Phase 2Czech Republic;Belgium;Germany;Italy
3EUCTR2014-000178-20-IT
(EUCTR)
01/02/201616/10/2015Therapy of MCT8 patients with the thyroid hormone analog Triac.Thyroid hormone analog therapy of patients with severe psychomotor retardation caused by mutations in the MCT8 thyroid hormone transporter: The Triac Trial. - Triac Trial in MCT8 patients This therapuetical trial will be conducted in patient with the Allan-Herndon-Dudley Syndrome (AHDS), casued by mutations in the thyroid hormone transporter MCT8. This results in the characteristic clinical phenotype of severe psychomotor retardation due to local hypothyroidism in the brain, in combination with high serum T3 and high normal serum TSH levels that lead to local hyperthyroidism in tissues that do not dependent on MCT8, resulting in tachycardia, low body weight and muscle wasting.;Therapeutic area: Diseases [C] - Hormonal diseases [C19]Trade Name: Téatrois (Tiratricol)
Product Name: Téatrois
Erasmus Medical CentreNULLAuthorised-recruitment may be ongoing or finishedFemale: no
Male: yes
40Phase 2Germany;Italy
4EUCTR2014-000178-20-FR
(EUCTR)
14/01/201614/12/2015Therapy of MCT8 patients with the thyroid hormone analog Triac.Thyroid hormone analog therapy of patients with severe psychomotor retardation caused by mutations in the MCT8 thyroid hormone transporter: The Triac Trial. - Triac Trial in MCT8 patients This therapuetical trial will be conducted in patient with the Allan-Herndon-Dudley Syndrome (AHDS), casued by mutations in the thyroid hormone transporter MCT8. This results in the characteristic clinical phenotype of severe psychomotor retardation due to local hypothyroidism in the brain, in combination with high serum T3 and high normal serum TSH levels that lead to local hyperthyroidism in tissues that do not dependent on MCT8, resulting in tachycardia, low body weight and muscle wasting.;Therapeutic area: Diseases [C] - Hormonal diseases [C19]Trade Name: Téatrois (Tiratricol)
Product Name: Téatrois
Erasmus Medical CentreCentre Hospitalier de ToulouseNot RecruitingFemale: no
Male: yes
40Phase 2France;Czech Republic;Canada;Belgium;Australia;South Africa;Germany;Italy
5EUCTR2014-000178-20-BE
(EUCTR)
12/08/201522/06/2015Therapy of MCT8 patients with the thyroid hormone analog Triac.Thyroid hormone analog therapy of patients with severe psychomotor retardation caused by mutations in the MCT8 thyroid hormone transporter: The Triac Trial. - Triac Trial in MCT8 patients This therapuetical trial will be conducted in patient with the Allan-Herndon-Dudley Syndrome (AHDS), casued by mutations in the thyroid hormone transporter MCT8. This results in the characteristic clinical phenotype of severe psychomotor retardation due to local hypothyroidism in the brain, in combination with high serum T3 and high normal serum TSH levels that lead to local hyperthyroidism in tissues that do not dependent on MCT8, resulting in tachycardia, low body weight and muscle wasting.;Therapeutic area: Diseases [C] - Hormonal diseases [C19]Trade Name: Téatrois (Tiratricol)
Product Name: Téatrois
Erasmus Medical CentreNULLAuthorised-recruitment may be ongoing or finishedFemale: no
Male: yes
40Phase 2Canada;Belgium;Australia;Chile;South Africa;Germany;Italy
6EUCTR2014-000178-20-DE
(EUCTR)
05/10/2015Therapy of MCT8 patients with the thyroid hormone analog Triac.Thyroid hormone analog therapy of patients with severe psychomotor retardation caused by mutations in the MCT8 thyroid hormone transporter: The Triac Trial. - Triac Trial in MCT8 patients This therapuetical trial will be conducted in patient with the Allan-Herndon-Dudley Syndrome (AHDS), casued by mutations in the thyroid hormone transporter MCT8. This results in the characteristic clinical phenotype of severe psychomotor retardation due to local hypothyroidism in the brain, in combination with high serum T3 and high normal serum TSH levels that lead to local hyperthyroidism in tissues that do not dependent on MCT8, resulting in tachycardia, low body weight and muscle wasting.;Therapeutic area: Diseases [C] - Hormonal diseases [C19]Trade Name: Téatrois (Tiratricol)
Product Name: Téatrois
INN or Proposed INN: Tiratricol
Erasmus Medical CentreNULLNot RecruitingFemale: no
Male: yes
40Phase 2France;Czech Republic;Canada;Belgium;Australia;Israel;South Africa;Germany;Italy