TNFi ( DrugBank: - )
1 disease
| ID | Disease name (Link within this page) | Number of trials |
|---|---|---|
| 46 | Malignant rheumatoid arthritis | 7 |
46. Malignant rheumatoid arthritis
Clinical trials : 4,356 / Drugs : 2,567 - (DrugBank : 415) / Drug target genes : 192 - Drug target pathways : 228
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT05306353 (ClinicalTrials.gov) | May 15, 2023 | 23/3/2022 | CD40L Antagonism in Rheumatoid Arthritis (RA) | Combining a CD40L-Binding Protein (VIB4920) With a TNF-alpha Inhibitor for the Treatment of Inadequately Controlled Rheumatoid Arthritis (ITN092AI) | Rheumatoid Arthritis | Drug: Placebo for VIB4920;Drug: VIB4920 with TNFi;Drug: VIB4920 without TNFi | National Institute of Allergy and Infectious Diseases (NIAID) | Immune Tolerance Network (ITN) | Not yet recruiting | 18 Years | 70 Years | All | 104 | Phase 2 | United States |
| 2 | NCT05305066 (ClinicalTrials.gov) | February 1, 2023 | 26/2/2022 | Stand UP to Rheumatoid Arthritis (SUPRA) | Innovative Trial Designs, Multi-omics and Advanced Computational Prediction to Transform Clinical Care in RA | Rheumatoid Arthritis | Drug: TNFi;Drug: Anti-IL6;Drug: JAKi | Marie Hudson, MD | McGill University Health Centre/Research Institute of the McGill University Health Centre;Montreal General Hospital;Lady Davis Institute | Recruiting | 18 Years | N/A | All | 75 | N/A | Canada |
| 3 | NCT04692493 (ClinicalTrials.gov) | September 22, 2021 | 15/12/2020 | RA-PRO PRAGMATIC TRIAL | A Real-World Comparative Effectiveness Trial of Treatment Strategies in Patients With Rheumatoid Arthritis: The RA-PRO Pragmatic Trial (RA-PROPR) | Rheumatoid Arthritis | Drug: targeted synthetic DMARD class;Drug: non-TNFi-biologic class | University of Alabama at Birmingham | Patient-Centered Outcomes Research Institute | Recruiting | 18 Years | N/A | All | 924 | Phase 3 | United States |
| 4 | NCT04985435 (ClinicalTrials.gov) | May 12, 2021 | 19/7/2021 | Better After CHoosing. Randomly Allocated or Patient Preference Based Treatment With Filgotinib or TNFi in RA (BACH) | Better After CHoosing. Randomly Allocated or Patient Preference Based Treatment With Filgotinib or TNFi in Patients With Active Rheumatoid Arthritis (BACH) | Rheumatoid Arthritis | Drug: Filgotinib;Drug: Anti-Tumor Necrosis Factor Alpha Drug (Product);Behavioral: 50 patients will have a Free Choice between Filgotinib and anti TNF | R.Bos | Galapagos NV;Medical Centre Leeuwarden;Leiden University Medical Center | Recruiting | 18 Years | 101 Years | All | 100 | Phase 4 | Netherlands |
| 5 | NCT04529902 (ClinicalTrials.gov) | August 17, 2020 | 25/8/2020 | Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - TNFi vs Abatacept | Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines - Tumor Necrosis Factor Inhibitors vs Abatacept | Rheumatoid Arthritis | Drug: Tumor Necrosis Factor Inhibitors;Drug: Abatacept | Brigham and Women's Hospital | National Institute on Aging (NIA);Rutgers University;Johns Hopkins University | Completed | 18 Years | N/A | All | 63013 | United States | |
| 6 | NCT01613027 (ClinicalTrials.gov) | February 2012 | 25/5/2012 | An Observational Study of MabThera in Participants With Severe Active Rheumatoid Arthritis | A Multicenter Observational Study of the Response to Rituximab (MabThera®) in Seropositive Patients With Rheumatoid Arthritis With Inadequate Response or Intolerance to Treatment With One or More Tumor Necrosis Factor Inhibitors (TNFi) | Rheumatoid Arthritis | Biological: Rituximab | Hoffmann-La Roche | NULL | Completed | 18 Years | N/A | All | 135 | N/A | Greece |
| 7 | NCT00853385 (ClinicalTrials.gov) | May 2009 | 27/2/2009 | A Phase 3 Study Comparing 2 Doses Of CP-690,550 And The Active Comparator, Humira (Adalimumab) Vs. Placebo For Treatment Of Rheumatoid Arthritis | Phase 3 Randomized, Double-Blind, Active Comparator, Placebo-Controlled Study Of The Efficacy And Safety Of 2 Doses Of CP 690,550 In Patients With Active Rheumatoid Arthritis On Background Methotrexate | Rheumatoid Arthritis | Drug: CP 690,550;Drug: CP-690,550;Other: Placebo;Biological: Biologic TNFi | Pfizer | NULL | Completed | 18 Years | N/A | All | 717 | Phase 3 | United States;Australia;Bosnia and Herzegovina;Bulgaria;Canada;Chile;Costa Rica;Croatia;Czech Republic;Denmark;Dominican Republic;Finland;Germany;Korea, Republic of;Mexico;Philippines;Poland;Slovakia;Spain;Thailand;United Kingdom |