THIAMINE ( DrugBank: Thiamine )


3 diseases
IDDisease name (Link within this page)Number of trials
8Huntington disease2
93Primary biliary cholangitis2
265Lipodystrophy1

8. Huntington disease


Clinical trials : 242 Drugs : 205 - (DrugBank : 62) / Drug target genes : 85 - Drug target pathways : 159
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT04478734
(ClinicalTrials.gov)
June 1, 202211/2/2020Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's DiseaseMulticentric Trial on the Use of Combined Therapy of Thiamine and Biotine in Patients With Huntington´s DiseaseHuntington DiseaseDrug: Moderate doses of Thiamine y Biotin;Drug: High doses of Thiamine y BiotinFundación Pública Andaluza para la gestión de la Investigación en SevillaCiberned (Centro de Investigación Biomédica en Red)Not yet recruiting18 YearsN/AAll24Phase 2Spain
2EUCTR2019-004360-22-ES
(EUCTR)
22/10/202110/01/2020Trial on the use of thiamine and biotin in patients with Huntington's disease.MULTI-TECHNICAL TEST ON THE USE OF COMBINED THERAPY OF THEMIN AND BIOTINE IN PATIENTS WITH HUNTINGTON'S DISEASE - Huntiam Huntington´s disease
MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]
Trade Name: Benerva
Product Name: Benerva
Product Name: Biotina
INN or Proposed INN: BIOTIN
Other descriptive name: Vitamin B7
Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (Ciberned)NULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
24Phase 2Spain

93. Primary biliary cholangitis


Clinical trials : 298 Drugs : 252 - (DrugBank : 59) / Drug target genes : 35 - Drug target pathways : 115
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT04893993
(ClinicalTrials.gov)
May 12, 20214/5/2021PBC Induced Fatigue Treated With ThiaminePBC Induced Fatigue Treated With Thiamine (PIFT) - The Effect of Oral Thiamine Supplement in 4 Weeks to Patients With Primary Biliary Cholangitis (PBC) and Chronic Fatigue. A Randomised Placebo Controlled Crossover StudyPrimary Biliary CirrhosisDrug: Thiamine;Drug: PlaceboHenning GrønbækAarhus University Hospital;Hospitalsapoteket Region Midtjylland;GCP-unit at Aarhus University Hospital, Aarhus, Denmark;Region Hovedstadens ApotekRecruiting18 YearsN/AAll36Phase 4Denmark
2EUCTR2020-004935-26-DK
(EUCTR)
25/02/202109/12/2020Vitamin B1 as treatment for chronic fatigue in patients with primary biliary cholangitisPBC induced fatigue treated with thiamine- The effect of oral thiamine supplement in 4 weeks to patients with primary biliary cholangitis (PBC) and chronic fatigue.A randomised, double-blinded, placebo-controlled, crossover study - PIFT Primary biliary cholangitis
MedDRA version: 21.0;Level: PT;Classification code 10080429;Term: Primary biliary cholangitis;System Organ Class: 10019805 - Hepatobiliary disorders
MedDRA version: 20.1;Level: LLT;Classification code 10066564;Term: Chronic fatigue;System Organ Class: 100000004867;Therapeutic area: Diseases [C] - Symptoms and general pathology [C23]
Trade Name: Tiamin SAD
INN or Proposed INN: THIAMINE
Other descriptive name: Tiamin DAK
Aarhus University HospitalNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes
36Phase 2Denmark

265. Lipodystrophy


Clinical trials : 112 Drugs : 155 - (DrugBank : 55) / Drug target genes : 25 - Drug target pathways : 97
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
Recruitment_
Status
Inclusion_
agemin
Inclusion_
agemax
Inclusion_
gender
Target_
size
PhaseCountries
1NCT00202228
(ClinicalTrials.gov)
July 200213/9/2005Lactate Metabolism Study in HIV Infected PersonsLactic Acid Metabolism in HIV-Infected Persons. Predicting Abnormalities in Lactate Production and Clearance Related to Treatment and Liver Disease and Measuring the Impact of Vitamin Supplementation.HIV Infections;AIDS;Lactic Acidosis;LipodystrophyDrug: cofactor supplementation (thiamine, riboflavin, L-carnitine)Queen's UniversityOntario HIV Treatment NetworkCompleted18 YearsN/ABoth30Phase 4Canada