Metformin Hydrochloride ( DrugBank: Metformin )


5 diseases
IDDisease name (Link within this page)Number of trials
81Congenital adrenal hyperplasia1
158Tuberous sclerosis1
265Lipodystrophy1
299Cystic fibrosis1
301Macular dystrophy1

81. Congenital adrenal hyperplasia


Clinical trials : 87 Drugs : 87 - (DrugBank : 23) / Drug target genes : 12 - Drug target pathways : 68
No.TrialIDDate_
enrollment
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Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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PhaseCountries
1EUCTR2013-002395-40-BE
(EUCTR)
24/03/201419/11/2013Prospective intervention trial with adjuvant metformin in girls and boys with classic congenital adrenal hyperplasia.Prospective intervention trial with adjuvant metformin in girls and boys with classic CAH (METFOR CAH). - METFOR CAH congenital adrenal hyperplasia (CAH)
MedDRA version: 16.1;Level: LLT;Classification code 10010323;Term: Congenital adrenal hyperplasia;System Organ Class: 100000004850;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Trade Name: Metformine Sandoz 850 mg filmomhulde tabletten
Product Name: Metformine
INN or Proposed INN: METFORMIN HYDROCHLORIDE
Other descriptive name: METFORMIN HYDROCHLORIDE
Ghent University HospitalNULLNot RecruitingFemale: yes
Male: yes
90Phase 3Belgium

158. Tuberous sclerosis


Clinical trials : 112 Drugs : 71 - (DrugBank : 19) / Drug target genes : 35 - Drug target pathways : 118
No.TrialIDDate_
enrollment
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registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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PhaseCountries
1EUCTR2011-001319-30-GB
(EUCTR)
04/04/201205/09/2011Metformin as a treatment for people with the genetic disease Tuberous Sclerosis Complex.A randomized, double-blind, parallel group, placebo-controlled trial of metformin in tuberous sclerosis complex. - Metformin in Tuberous Sclerosis Complex (MiTS) V1.0 Tuberous Sclerosis Complex
MedDRA version: 14.1;Level: PT;Classification code 10045138;Term: Tuberous sclerosis;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Trade Name: metformin (generic)
Product Name: Metformin
Product Code: n/a
INN or Proposed INN: metformin hydrochloride
Other descriptive name: -
University Hospitals Bristol NHS Foundation TrustNULLNot RecruitingFemale: yes
Male: yes
100Phase 4United Kingdom

265. Lipodystrophy


Clinical trials : 112 Drugs : 155 - (DrugBank : 55) / Drug target genes : 25 - Drug target pathways : 97
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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Inclusion_
agemin
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PhaseCountries
1NCT00015691
(ClinicalTrials.gov)
April 20011/5/2001Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Patients With Insulin and Fat AbnormalitiesA Randomized, Double-Blind, Placebo-Controlled Study of Metformin and Rosiglitazone, Alone or in Combination, in HIV-Infected Subjects With Hyperinsulinemia and Elevated Waist/Hip RatioHIV Infections;Lipodystrophy;HyperinsulinemiaDrug: Metformin hydrochloride;Drug: Rosiglitazone maleateNational Institute of Allergy and Infectious Diseases (NIAID)NULLCompleted18 Years65 YearsBoth105N/AUnited States

299. Cystic fibrosis


Clinical trials : 1,695 Drugs : 1,527 - (DrugBank : 268) / Drug target genes : 111 - Drug target pathways : 174
No.TrialIDDate_
enrollment
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registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
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agemin
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PhaseCountries
1NCT04530383
(ClinicalTrials.gov)
February 14, 202224/8/2020Effects of Metformin on Airway Ion Channel Dysfunction in Cystic Fibrosis-related DiabetesA Randomized, Double-blind, Crossover Clinical Trial of Metformin in Those With CFRD on CFTR Modulator Therapy to Improve Ion Channel FunctionCystic Fibrosis-related Diabetes;Cystic FibrosisDrug: Metformin HydrochlorideUniversity of Kansas Medical CenterNULLRecruiting18 YearsN/AAll36Phase 2United States

301. Macular dystrophy


Clinical trials : 46 Drugs : 42 - (DrugBank : 11) / Drug target genes : 9 - Drug target pathways : 67
No.TrialIDDate_
enrollment
Date_
registration
Public_titleScientific_titleConditionInterventionPrimary_
sponsor
Secondary_
sponsor
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Inclusion_
agemin
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PhaseCountries
1NCT04545736
(ClinicalTrials.gov)
November 23, 202010/9/2020Oral Metformin for Treatment of ABCA4 RetinopathyOral Metformin for Treatment of ABCA4 RetinopathyABCA4 Retinopathy;Stargardt Disease;Retinal Dystrophy;Retinal DegenerationDrug: Metformin hydrochlorideNational Eye Institute (NEI)NULLRecruiting12 YearsN/AAll38Phase 1/Phase 2United States