DDrare: Database of Drug Development for Rare Diseases

35. 天疱瘡
［臨床試験数：87，薬物数：114（DrugBank：37），標的遺伝子数：17，標的パスウェイ数：158］

Searched query = "Pemphigus"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = ALXN1830; ARGX-113; Acetaminophen; Acetaminophen/paracetamol; Acetate; Antihistamine (cetirizine or equivalent); Azathioprine; CELLCEPT®; CORTANCYL 20 mg; Carboxymethylcellulose; CellCept 500 mg comprimidos recubiertos; CellCept®500 mg comprimidos; Cellcept® in autoimmune bullous dermatoses; Cellulose; Cetirizine; Cohort 1: 1.0 x 10^8 PolyTregs; Cohort 2: 2.5x10^8 PolyTregs; Combination of Protein A Immunoadsorption, Rituximab, Dexamethasone plus Azathioprine; Cortancyl; Corticosteroids'therapy; Cotton; Cyclophosphamide; DSG3-CAART; Dapsone; Dermoval; Device: Carboxymethylcellulose with ionic silver (Aquacel Ag); Device: Cellulose acetate with petrolatum; Device: Cotton gauze with petrolatum; Device: Nanocrystalline silver (Acticoat); Dexamethasone; Dexamethasone (50mg 1dd6, 3 consecutive days/month); Dexamethasone 0.5mg/5ml solution; Dexamethasone 0.5mg/5ml solution in Mucolox™; EFGARTIGIMOD ALFA; Efgartigimod; Efgartigimod PH20 SC; Efgartigimod alfa; Enbrel (Etanercept); Etanercept; Filgrastim; GLYCINE; GSK1841157; General Corticotherapy; Glycine; Hematopoietic stem cell transplantation; Human interleukin-2; INCB050465; INCB050465 0.3 mg; INCB050465 0.3mg; INCB050465 1.0 mg; INCB050465 1.0mg; INCB050465 2.5mg; INCB050465 HYDROCHLORIDE; INTERLEUKIN-2; IVIg; Ianalumab; Imatinib; Infliximab; Intratect; Intratect 5%; Intravenous immunoglobulin; KC706; MABTHERA; MABTHERA®; MMF; MTX; MabThera; Mabthera; Mabthéra; Mathéra; Methotrexate; Methylprednisolone; Micofenolato mofetilo; Mycophenolate; Mycophenolate Mofetil; Mycophenolate Mofetil (MMF) 3 g/Day; Mycophenolate Mofetil 2 g/Day; Mycophenolate mofetil; OFATUMUMAB; ONO-4059; Ofatumumab; Other: Autologous Platelet rich plasma; Other: IVIg; PI-0824; PREDNISONE; PRN1008; PRN1008 (Rilzabrutinib); PRN1008 Freebase; PRN1008 Oral Tablet; Paracetamol; Parsaclisib; Petrolatum; Prednisolone; Prednisone; Prednisone/Prednisolone; RITUXIMAB; RO0452294/V02; RO1061443/F02; Rapamycin; Recombinant human interleukin-2 (rhIL-2); Rituximab; Rituximab (MABTHERA® or RITUXAN®).; Rituximab and Cyclophosphamide IV; Silver; Sirolimus; Sirolimus (formerly known as Rapamycin); TPM203; Tirabrutinib; Triamcinolone; Triamcinolone Acetonide; VAY736; WATER FOR INJECTION; Water; [NA]

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	ChiCTR-OIC-17011759	2016-08-01	2017-06-26	pharmacogenomics of Azathioprine induced myelosuppression in the treatment of Pemphigus Vulgaris--study of mutation in TPMT*3 and NUDT15 gene in Chinese people and changes in blood configuration(hemogram).	pharmacogenomics of Azathioprine induced myelosuppression in the treatment of Pemphigus Vulgaris--study of mutation in TPMT*3 and NUDT15 gene in Chinese people and changes in blood configuration(hemogram).	Pemphigus Vulgaris	Case series:Azathioprine;	Dermatological Department, West China hospital, Sichuan University	NULL	Completed	18	65	Both	Case series:60;	I (Phase 1 study)	China
2	NCT00626678 (ClinicalTrials.gov)	January 2008	21/2/2008	Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone	A Randomized, Double-Blind, Placebo-Controlled Phase II Trial of Adjuvant Azathioprine Therapy in New Cases of Pemphigus Vulgaris Receiving Prednisone	Pemphigus Vulgaris	Drug: Azathioprine;Drug: Prednisone;Drug: Placebo	Tehran University of Medical Sciences	NULL	Completed	10 Years	75 Years	Both	48	Phase 2	Iran, Islamic Republic of
3	NCT00656656 (ClinicalTrials.gov)	January 2008	7/4/2008	Immunoadsorption, Dexamethasone Pulse Therapy and Rituximab for Pemphigus	Combined Treatment of Autoimmune Bullous Diseases With Protein A Immunoadsorption, Dexamethasone Pulse Therapy and Rituximab	Pemphigus	Drug: Combination of Protein A Immunoadsorption, Rituximab, Dexamethasone plus Azathioprine	University of Luebeck	NULL	Completed	18 Years	N/A	All	23	Phase 2	Germany

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

ChiCTR-OIC-17011759

2016-08-01

2017-06-26

pharmacogenomics of Azathioprine induced myelosuppression in the treatment of Pemphigus Vulgaris--study of mutation in TPMT*3 and NUDT15 gene in Chinese people and changes in blood configuration(hemogram).

Pemphigus Vulgaris

Case series:Azathioprine;

Dermatological Department, West China hospital, Sichuan University

NULL

Completed

Both

Case series:60;

I (Phase 1 study)

China

NCT00626678
(ClinicalTrials.gov)

January 2008

21/2/2008

Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone

A Randomized, Double-Blind, Placebo-Controlled Phase II Trial of Adjuvant Azathioprine Therapy in New Cases of Pemphigus Vulgaris Receiving Prednisone

Pemphigus Vulgaris

Drug: Azathioprine;Drug: Prednisone;Drug: Placebo

Tehran University of Medical Sciences

NULL

Completed

10 Years

75 Years

Both

Phase 2

Iran, Islamic Republic of

NCT00656656
(ClinicalTrials.gov)

January 2008

7/4/2008

Immunoadsorption, Dexamethasone Pulse Therapy and Rituximab for Pemphigus

Combined Treatment of Autoimmune Bullous Diseases With Protein A Immunoadsorption, Dexamethasone Pulse Therapy and Rituximab

Pemphigus

Drug: Combination of Protein A Immunoadsorption, Rituximab, Dexamethasone plus Azathioprine

University of Luebeck

NULL

Completed

18 Years

N/A

All

Phase 2

Germany