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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1(R)-[N-metil-11C1-PK11195(PK)----1件: 127
218-F]DPA-714----1件: 127
318F-AV-1451----3件: 5, 7, 127
418F-AV-45----2件: 6, 127
518F-FDG1件: Fludeoxyglucose (18F)---13件: 5, 6, 7, 8, 13, 41, 46, 53, 84, 85, 96, 127, 300
618F-RO6958948----3件: 5, 7, 127
718F]DPA-714----2件: 13, 127
8[18F]PI-2620----2件: 6, 127
9AL----10件: 5, 7, 13, 28, 51, 67, 86, 97, 114, 127
10AL001----2件: 2, 127
11AMANTADINE1件: Amantadine2件: D00777 ,
D07441 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬4件: 6, 8, 13, 127
12Amiodarone1件: Amiodarone2件: D00636 ,
D02910 		16件: ADRA1A,
ADRA1B,
ADRA1D,
ADRB1,
KCND3,
KCNJ11,
KCNJ12,
KCNJ3,
KCNJ5,
KCNJ8,
KCNQ1,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		32件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Dilated cardiomyopathy, Dopaminergic synapse, Estrogen signaling pathway, Gap junction, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, Insulin secretion, Morphine addiction, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, Pancreatic secretion, Protein digestion and absorption, Regulation of lipolysis in adipocytes, Renin secretion, Retrograde endocannabinoid signaling, Salivary secretion, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Type II diabetes mellitus, Vascular smooth muscle contraction, Vibrio cholerae infection, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 28, 127
13Amyvid1件: Florbetapir (18F)---2件: 13, 127
14AV1451 Tau----1件: 127
15Behavioral: Cognitive and Behavioral experimental tasks----2件: 6, 127
16Behavioral: ECOCAPTURE----2件: 6, 127
17Behavioral: ICM_APATHY_TASKS----2件: 6, 127
18BIIB092----3件: 5, 7, 127
19Blood sample----18件: 8, 13, 46, 49, 51, 53, 61, 65, 66, 84, 96, 97, 107, 127, 235, 274, 288, 299
20Brain PET scan----3件: 5, 7, 127
21C-11 PiB1件: Pittsburgh Compound B---1件: 127
22Carbonate1件: Carbonate ion---12件: 2, 13, 17, 18, 19, 46, 53, 75, 96, 127, 235, 299
23CENSAVUDINE1件: Censavudine1件: D10550 --2件: 2, 127
24Chloride1件: Chloride ion---29件: 6, 11, 13, 14, 34, 46, 50, 51, 53, 60, 65, 67, 78, 96, 97, 107, 127, 168, 171, 193, 227, 228, 251, 271, 288, 296, 297, 299, 338
25Citalopram1件: Citalopram2件: D00822 ,
D07704 		1件: SLC6A4 💬2件: Serotonergic synapse, Synaptic vesicle cycle 💬7件: 6, 8, 13, 18, 46, 98, 127
26Davunetide1件: Davunetide1件: D09401 --3件: 5, 7, 127
27Davunetide (AL-108, NAP)1件: Davunetide1件: D09401 --3件: 5, 7, 127
28Diagnostic Test: [18F]-RO6958948----5件: 5, 6, 7, 17, 127
29Diagnostic Test: Elecsys (Roche) Abeta42, Ttau and Ptau----5件: 5, 6, 7, 17, 127
30Diagnostic Test: Flutemetamol F18 Injection2件: Flutemetamol,
Flutemetamol (18F)		---5件: 5, 6, 7, 17, 127
31Diagnostic Test: Lumipulse (Fujirebio) Abeta42, Ttau and Ptau----5件: 5, 6, 7, 17, 127
32Diagnostic Test: Neuropsychological assessment----2件: 6, 127
33Diagnostic Test: Supplementary Neuropsychological Assessment - Parkinson's Disease----2件: 6, 127
34DNL593----1件: 127
35Donepezil1件: Donepezil2件: D00670 ,
D07869 		1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬9件: 5, 6, 13, 46, 78, 124, 127, 156, 206
36DPA----5件: 2, 6, 13, 85, 127
37EVP-0334----1件: 127
38F 18 T807----1件: 127
39F-18----2件: 5, 127
40F-18 FDG----1件: 127
41Ferulic acid1件: Ferulic acid---1件: 127
42Florbetapir (18F)1件: Florbetapir (18F)---1件: 127
43Florbetapir 18F----1件: 127
44Florbetapir 18F Injection----1件: 127
45Flortaucipir1件: Flortaucipir1件: D11210 1件: MAPT 💬4件: Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬3件: 5, 7, 127
46Flortaucipir F181件: Flortaucipir1件: D11210 1件: MAPT 💬4件: Alzheimer disease, MAPK signaling pathway, Parkinson disease, Pathways of neurodegeneration - multiple diseases 💬3件: 5, 7, 127
47Flutemetamol1件: Flutemetamol (18F)---5件: 5, 6, 7, 17, 127
48Flutemetamol F182件: Flutemetamol,
Flutemetamol (18F)		---5件: 5, 6, 7, 17, 127
49FRM-0334----1件: 127
50GALANTAMINE1件: Galantamine2件: D02173 ,
D04292 		1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬2件: 6, 127
51Galantamine hydrobromide1件: Galantamine2件: D02173 ,
D04292 		1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬2件: 6, 127
52Histone Deacetylase Inhibitor----1件: 127
53Intranasal oxytocin1件: Oxytocin1件: D00089 1件: OXTR 💬4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬2件: 127, 193
54Latozinemab----1件: 127
55Leucine1件: Leucine1件: D00030 --11件: 5, 6, 7, 19, 65, 96, 97, 127, 283, 284, 299
56Leuco-methylthioninium bis(hydromethanesulfonate)1件: Methylthioninium---1件: 127
57LITHIUM CARBONATE2件: Carbonate ion,
Lithium carbonate		1件: D00801 --6件: 2, 13, 17, 18, 19, 127
58LMTM----1件: 127
59LMTM/TRx0237----1件: 127
60Lumbar Puncture----6件: 6, 13, 19, 96, 97, 127
61Memantine1件: Memantine2件: D04905 ,
D08174 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬7件: 2, 6, 8, 13, 49, 127, 205
62MEMANTINE HYDROCHLORIDE1件: Memantine2件: D04905 ,
D08174 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬3件: 2, 6, 127
63Metformin1件: Metformin2件: D00944 ,
D04966 		2件: PRKAA1,
PRKAA2 💬		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
64Methylprednisolone1件: Methylprednisolone6件: D00407 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
65Methylthioninium1件: Methylthioninium---1件: 127
66Methylthioninium chloride3件: Chloride ion,
Methylene blue,
Methylthioninium		2件: D02312 ,
D10537 		--1件: 127
67MTC TRx0014-001 capsules----1件: 127
68N,N,N',N'-tetramethyl-10H-phenothiazine-3,7-diaminium bis(methanesulfonate)1件: Phenothiazine1件: D02601 --1件: 127
69N,N,N?,N?-tetramethyl-10H-phenothiazine-3,7-diaminium bis(methanesulfonate)1件: Phenothiazine1件: D02601 --1件: 127
70N,N,N’,N’-tetramethyl-10H-phenothiazine-3,7-diaminium bis(methanesulfonate)1件: Phenothiazine1件: D02601 --1件: 127
71Neurohormonal mechanisms----2件: 6, 127
72Novolin-R insulin----1件: 127
73Open label - AL001----1件: 127
74Other: 13C6 Leucine1件: Leucine1件: D00030 --3件: 5, 7, 127
75Other: MRI----3件: 6, 127, 206
76Oxytocin1件: Oxytocin1件: D00089 1件: OXTR 💬4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬6件: 6, 72, 127, 193, 206, 226
77PBFT02----1件: 127
78PEA-LUT----1件: 127
79Phenothiazine1件: Phenothiazine1件: D02601 --1件: 127
80Pittsburgh Compound B1件: Pittsburgh Compound B---2件: 6, 127
81Pittsburgh Compound B (C-11 PiB)1件: Pittsburgh Compound B---1件: 127
82PR006----1件: 127
83Prednisone1件: Prednisone1件: D00473 1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬48件: 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
84Rituximab1件: Rituximab1件: D02994 1件: MS4A1 💬1件: Hematopoietic cell lineage 💬49件: 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
85ROTIGOTINE1件: Rotigotine1件: D05768 1件: DRD2 💬8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬2件: 6, 127
86Rotigotine 4Mg/24Hrs Patch1件: Rotigotine1件: D05768 1件: DRD2 💬8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 127
87Rotigotine 6Mg/24Hrs Patch1件: Rotigotine1件: D05768 1件: DRD2 💬8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 127
88Saline Nasal Mist----1件: 127
89Sirolimus1件: Sirolimus1件: D00753 1件: MTOR 💬51件: AMPK signaling pathway, Acute myeloid leukemia, Adipocytokine signaling pathway, Alzheimer disease, Amyotrophic lateral sclerosis, Apelin signaling pathway, Autophagy - animal, Autophagy - other, Breast cancer, Cellular senescence, Central carbon metabolism in cancer, Chemical carcinogenesis - receptor activation, Choline metabolism in cancer, Colorectal cancer, Diabetic cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, Gastric cancer, Glioma, Growth hormone synthesis, secretion and action, HIF-1 signaling pathway, Hepatocellular carcinoma, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Huntington disease, Insulin resistance, Insulin signaling pathway, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Longevity regulating pathway, Longevity regulating pathway - multiple species, MicroRNAs in cancer, Neutrophil extracellular trap formation, PD-L1 expression and PD-1 checkpoint pathway in cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Phospholipase D signaling pathway, Prostate cancer, Proteoglycans in cancer, Shigellosis, Spinocerebellar ataxia, Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, mTOR signaling pathway 💬36件: 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 89, 98, 127, 137, 157, 158, 192, 222, 277, 278, 279, 280, 281, 283, 285, 331
90Synthetic stereopure antisense oligonucleotide targeting human C9orf72 hexanucleotide repeat-containing mRNA transcripts----2件: 2, 127
91Syntocinon1件: Oxytocin1件: D00089 1件: OXTR 💬4件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Oxytocin signaling pathway, cAMP signaling pathway 💬3件: 6, 127, 193
92T807----1件: 127
93Tau (18-F-AV-1451)----1件: 127
94TOLCAPONE1件: Tolcapone1件: D00786 1件: COMT 💬4件: Dopaminergic synapse, Metabolic pathways, Steroid hormone biosynthesis, Tyrosine metabolism 💬3件: 6, 28, 127
95TPN-101----2件: 2, 127
96TPN-101, 400 mg/day----3件: 2, 5, 127
97TRx0237----1件: 127
98Verdiperstat1件: Verdiperstat1件: D11684 1件: MPO 💬5件: Acute myeloid leukemia, Drug metabolism - other enzymes, Neutrophil extracellular trap formation, Phagosome, Transcriptional misregulation in cancer 💬3件: 2, 17, 127
99Vizamyl1件: Flutemetamol (18F)---3件: 5, 7, 127
100Vizamyl (flutemetamol(F-18))2件: Flutemetamol,
Flutemetamol (18F)		---3件: 5, 7, 127
101WVE-004----2件: 2, 127