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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1(4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-3,6-dimethyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile----1件: 231
24-PBA----1件: 231
3Abdominal ultrasound----1件: 231
4Acetaminophen1件: Acetaminophen1件: D00217 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬16件: 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
5ADS-001----1件: 231
6Aerosolized human Alpha-1 Antitrypsin----1件: 231
7Albumin (Human) 20%, United States Pharmacopeia (USP)----1件: 231
8Albuterol1件: Salbutamol1件: D02147 1件: ADRB2 💬9件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬8件: 12, 13, 86, 89, 113, 231, 256, 299
9Albuterol inhaler.1件: Salbutamol1件: D02147 1件: ADRB2 💬9件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 231, 299
10ALN-61444----1件: 231
11ALN-77412----1件: 231
12ALN-AAT----1件: 231
13ALN-AAT02----1件: 231
14Alpha 1-Antitrypsin1件: Alpha-1-proteinase inhibitor---2件: 231, 298
15Alpha 1-Proteinase Inhibitor1件: Alpha-1-proteinase inhibitor---1件: 231
16Alpha 1-proteinase inhibitor (human)1件: Alpha-1-proteinase inhibitor---1件: 231
17Alpha-1 Antitrypsin (AAT)----1件: 231
18Alpha-1 Antitrypsin (human)----1件: 231
19Alpha-1 MP----1件: 231
20Alpha-1 proteinase inhibitor (human)----1件: 231
21ALPHA-1-ANTITRYPSIN1件: Alpha-1-proteinase inhibitor---1件: 231
22Alpha1-Proteinase Inhibitor1件: Alpha-1-proteinase inhibitor---2件: 231, 299
23Alpha1-Proteinase Inhibitor (Human)1件: Alpha-1-proteinase inhibitor---2件: 231, 299
24ALVELESTAT1件: Alvelestat---1件: 231
25Alvelestat (MPH966)1件: Alvelestat---1件: 231
26Alvelestat oral tablet - dose 11件: Alvelestat---1件: 231
27Alvelestat oral tablet - dose 21件: Alvelestat---1件: 231
28Alvelestat tosylate1件: Alvelestat---1件: 231
29API----2件: 231, 299
30API-AAT----1件: 231
31API-AAT, AD00370, ARC-AAT, API drug Substance----1件: 231
32ARC-AAT----1件: 231
33ARC-AAT Injection----1件: 231
34ARO-AAT----1件: 231
35ARO-AAT Injection----1件: 231
36Aspirin1件: Acetylsalicylic acid1件: D00109 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬12件: 13, 22, 34, 46, 49, 51, 58, 86, 113, 158, 210, 231
37Belcesiran----1件: 231
38Blood draw----5件: 6, 19, 65, 231, 299
39Blood draw.----2件: 231, 299
40Carbamazepine1件: Carbamazepine1件: D00252 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬2件: 13, 231
41Dose of 60 mg/kg alpha1-proteinase inhibitor1件: Alpha-1-proteinase inhibitor---1件: 231
42Dose of 60 mg/kg Fraction IV-1 Alpha1-Proteinase Inhibitor1件: Alpha-1-proteinase inhibitor---1件: 231
43Drug-Carbamazepine (Tegretol XR)1件: Carbamazepine1件: D00252 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 231
44Fentanyl1件: Fentanyl2件: D00320 ,
D01399 		1件: OPRM1 💬3件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬4件: 46, 70, 215, 231
45Glassia1件: Alpha-1-proteinase inhibitor---1件: 231
46History and physical----1件: 231
47History and physical exam.----2件: 231, 299
48Hyaluronic acid1件: Hyaluronic acid1件: D08043 --5件: 46, 53, 70, 226, 231
49Hyaluronic Acid Inhalation Solution1件: Hyaluronic acid1件: D08043 --1件: 231
50INBRX-101/rhAAT-Fc----1件: 231
51Intravenous catheter----1件: 231
52Kamada -AAT for Inhalation or inhaled AAT (AAT)----1件: 231
53Kamada-AAT for inhalation----1件: 231
54Kamada-AAT for Inhalation, 160mg----1件: 231
55Kamada-AAT for Inhalation, 80mg----1件: 231
56Kamada-API----1件: 231
57Lidocaine1件: Lidocaine3件: D00358 ,
D02086 ,
D08127 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬12件: 6, 13, 34, 46, 51, 70, 86, 107, 168, 226, 231, 256
58Liver biopsy----4件: 93, 171, 231, 240
59Lorazepam1件: Lorazepam1件: D00365 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 36, 231
60Midazolam1件: Midazolam3件: D00550 ,
D00696 ,
D05028 		16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 231, 272, 298
61MPH966----2件: 228, 231
62None----16件: 6, 46, 51, 65, 78, 84, 85, 96, 97, 140, 160, 161, 171, 231, 271, 299
63None assigned1件: Interleukin-1 alpha, human recombinant---2件: 231, 299
64OctaAlpha1----1件: 231
65Ondansetron1件: Ondansetron2件: D00456 ,
D00678 		5件: HTR3A,
HTR3B,
HTR3C,
HTR3D,
HTR3E 💬		2件: Serotonergic synapse, Taste transduction 💬4件: 6, 97, 107, 231
66Other: Liver questionnaire----1件: 231
67Other: Sterile Normal Saline (0.9% NaCl)----1件: 231
68Other: Withdrawal from alpha1 antitrypsin replacement therapy----1件: 231
69Oxycodone1件: Oxycodone3件: D03783 ,
D05312 ,
D05462 		3件: OPRD1,
OPRK1,
OPRM1 💬		5件: Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway 💬7件: 6, 13, 46, 70, 226, 231, 298
70Oxycodone/Acetaminophen1件: Acetaminophen1件: D00217 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 231
71PBA----1件: 231
72PHP-303----1件: 231
73Prolastin----3件: 231, 298, 299
74Prolastin-C1件: Alpha-1-proteinase inhibitor---2件: 231, 298
75Prolastin-C, 120 mg/kg1件: Alpha-1-proteinase inhibitor---1件: 231
76Prolastin-C, 60 mg/kg1件: Alpha-1-proteinase inhibitor---1件: 231
77Pulmonary function testing.----2件: 231, 299
78RAAV1-CB-hAAT----1件: 231
79RECOMBINANT ADENO-ASSOCIATED VIRAL VECTOR EXPRESSING THE HUMAN ALPHA-1-ANTITRYPSIN GENE1件: Alpha-1-proteinase inhibitor---1件: 231
80Retinoic acid1件: Tretinoin1件: D00094 3件: PML,
RARA,
RARB 💬		12件: Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Influenza A, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis 💬2件: 94, 231
81Retinoic Acid Receptor gamma Agonist1件: Tretinoin1件: D00094 3件: PML,
RARA,
RARB 💬		12件: Acute myeloid leukemia, Endocytosis, Estrogen signaling pathway, Gastric cancer, Herpes simplex virus 1 infection, Influenza A, Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer, Th17 cell differentiation, Transcriptional misregulation in cancer, Ubiquitin mediated proteolysis 💬1件: 231
82RO3300074----1件: 231
83VX-814----1件: 231
84VX-864----1件: 231
85VX864----1件: 231