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No. 薬物名(臨床試験情報から抽出) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1(S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazo----1件: 284
2(S)-4,5-dihydro-2-[2-hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate magnesium hydroxide3件: Hydroxide ion,
Magnesium,
Magnesium hydroxide
1件: D00731 --1件: 284
3(S)-4,5-dihydro-2[hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-m----1件: 284
4(S)-4,5-dihydro-2[hydroxy-3-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylate magnesium hydroxide3件: Hydroxide ion,
Magnesium,
Magnesium hydroxide
1件: D00731 --1件: 284
5Abatacept1件: Abatacept1件: D03203 2件: CD80,
CD86 💬
12件: Allograft rejection, Autoimmune thyroid disease, Cell adhesion molecules, Graft-versus-host disease, Intestinal immune network for IgA production, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Transcriptional misregulation in cancer, Type I diabetes mellitus, Viral myocarditis 💬26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
6Alefacept1件: Alefacept1件: D02800 1件: CD58 💬2件: Cell adhesion molecules, Epstein-Barr virus infection 💬6件: 37, 60, 65, 164, 284, 285
7ALEMTUZUMAB1件: Alemtuzumab1件: D02802 1件: CD52 💬-17件: 13, 15, 19, 20, 36, 43, 44, 46, 51, 60, 63, 65, 85, 96, 164, 283, 284
8Allogeneic Bone Marrow Transplantation----9件: 60, 62, 65, 96, 164, 283, 284, 285, 286
9Allogeneic hematopoietic stem cell transplantation----8件: 28, 51, 60, 62, 65, 164, 284, 285
10Alpha beta depletion----2件: 60, 284
11Anti-Thymocyte Globulin----18件: 11, 13, 14, 36, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 164, 283, 284, 285
12Antithymocyte Globulin----3件: 60, 65, 284
13Bone marrow transplantation----4件: 51, 60, 284, 285
14BPX-501 T cells----4件: 65, 284, 285, 326
15Busulfan1件: Busulfan1件: D00248 --13件: 19, 20, 28, 36, 49, 51, 60, 65, 164, 274, 284, 285, 326
16Busulfan, Cyclophosphamide, ATG, GCSF2件: Busulfan,
Cyclophosphamide
3件: D00248 ,
D00287 ,
D07760
--2件: 65, 284
17Busulfan, Fludarabine, ATG, TLI2件: Busulfan,
Fludarabine
3件: D00248 ,
D01907 ,
D07966
1件: RRM1 💬5件: Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism 💬2件: 65, 284
18Campath, Fludarabine, Cyclophosphamide2件: Cyclophosphamide,
Fludarabine
4件: D00287 ,
D01907 ,
D07760 ,
D07966
1件: RRM1 💬5件: Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism 💬2件: 65, 284
19CD3/CD19 depleted leukocytes----1件: 284
20CD34 Stem Cell Selection Therapy----3件: 60, 65, 284
21CD45RA depleted leukocytes----1件: 284
22Cyclophosphamide1件: Cyclophosphamide2件: D00287 ,
D07760
--45件: 11, 13, 14, 16, 19, 20, 26, 28, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 56, 60, 62, 65, 66, 84, 85, 93, 96, 162, 164, 172, 205, 222, 224, 256, 265, 274, 283, 284, 285, 288, 326, 331
23Cyclophosphamide Dose Level 11件: Cyclophosphamide2件: D00287 ,
D07760
--2件: 65, 284
24Cyclophosphamide Dose Level 21件: Cyclophosphamide2件: D00287 ,
D07760
--2件: 65, 284
25Cyclophosphamide Dose Level 31件: Cyclophosphamide2件: D00287 ,
D07760
--2件: 65, 284
26Cyclophosphamide Dose Level 41件: Cyclophosphamide2件: D00287 ,
D07760
--2件: 65, 284
27Cyclosporine1件: Cyclosporine1件: D00184 5件: PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬
33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬37件: 11, 19, 20, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 107, 162, 164, 222, 226, 228, 234, 283, 284, 285, 302
28DACLIZUMAB1件: Daclizumab1件: D03639 1件: IL2RA 💬11件: Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Human T-cell leukemia virus 1 infection, JAK-STAT signaling pathway, Measles, PI3K-Akt signaling pathway, Pathways in cancer, Th1 and Th2 cell differentiation, Th17 cell differentiation, Viral protein interaction with cytokine and cytokine receptor 💬8件: 13, 56, 60, 65, 97, 107, 283, 284
29Deferasirox1件: Deferasirox1件: D03669 --3件: 254, 284, 286
30Deferitazole1件: Deferitazole1件: D10388 --1件: 284
31Deferoxamine1件: Deferoxamine2件: D01186 ,
D03670
--2件: 284, 286
32Desferal1件: Deferoxamine2件: D01186 ,
D03670
--2件: 284, 286
33DFO----3件: 46, 284, 286
34ELTROMBOPAG1件: Eltrombopag---5件: 60, 63, 65, 284, 285
35Enriched Hematopoetic Stem Cell Infusion----3件: 13, 19, 284
36Exjade1件: Deferasirox1件: D03669 --3件: 254, 284, 286
37FBS0701----1件: 284
38FBS0701 CAPSULE----1件: 284
39FBS0701/SSP004184----1件: 284
40Filgrastim1件: Filgrastim1件: D03235 1件: CSF3R 💬5件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬28件: 2, 6, 13, 25, 26, 28, 34, 35, 38, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 96, 113, 164, 256, 283, 284, 285, 296, 331
41Fludarabine1件: Fludarabine2件: D01907 ,
D07966
1件: RRM1 💬5件: Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism 💬18件: 13, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
42Fludarabine monophosphate1件: Fludarabine2件: D01907 ,
D07966
1件: RRM1 💬5件: Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism 💬3件: 65, 284, 326
43Fludarabine phosphate2件: Fludarabine,
Phosphate ion
2件: D01907 ,
D07966
1件: RRM1 💬5件: Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism 💬12件: 28, 36, 49, 51, 60, 62, 65, 96, 283, 284, 285, 286
44G-CSF1件: Filgrastim1件: D03235 1件: CSF3R 💬5件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬16件: 2, 6, 11, 13, 16, 47, 49, 51, 60, 62, 65, 85, 96, 284, 285, 331
45Human Placental Derived Stem Cell----4件: 19, 20, 60, 284
46Hydroxide1件: Hydroxide ion---5件: 11, 46, 96, 97, 284
47Hydroxyurea1件: Hydroxyurea1件: D00341 1件: RRM2 💬6件: Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway 💬8件: 3, 13, 19, 20, 65, 85, 86, 284
48ICL670----3件: 60, 284, 286
49Iron1件: Iron---6件: 18, 96, 97, 238, 254, 284
50IRON CHELATING AGENTS----1件: 284
51L-leucine1件: Leucine1件: D00030 --1件: 284
52Lenalidomide1件: Lenalidomide1件: D04687 1件: TNF 💬67件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬8件: 16, 26, 28, 34, 49, 284, 300, 331
53Leucine1件: Leucine1件: D00030 --11件: 5, 6, 7, 19, 65, 96, 97, 127, 283, 284, 299
54Leukapheresis----5件: 49, 51, 96, 284, 285
55Magnesium1件: Magnesium---19件: 3, 6, 11, 13, 15, 46, 64, 70, 93, 97, 166, 225, 235, 256, 284, 291, 296, 297, 298
56Magnesium hydroxide3件: Hydroxide ion,
Magnesium,
Magnesium hydroxide
1件: D00731 --1件: 284
57Melphalan1件: Melphalan1件: D00369 --15件: 11, 13, 14, 19, 20, 28, 60, 62, 65, 96, 164, 234, 284, 285, 299
58Mesenchymal Stromal Cells1件: Human Umbilical Cord Mesenchymal Stem Cells---10件: 2, 36, 49, 51, 60, 96, 97, 107, 274, 284
59Methotrexate1件: Methotrexate2件: D00142 ,
D02115
2件: DHFR,
DHFR2 💬
5件: Antifolate resistance, Biosynthesis of cofactors, Folate biosynthesis, Metabolic pathways, One carbon pool by folate 💬38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
60Methylprednisolone1件: Methylprednisolone6件: D00407 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002
1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
61Mycophenolate1件: Mycophenolic acid1件: D05096 2件: IMPDH1,
IMPDH2 💬
3件: Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
62Mycophenolate mofetil2件: Mycophenolate mofetil,
Mycophenolic acid
4件: D00752 ,
D05094 ,
D05095 ,
D05096
2件: IMPDH1,
IMPDH2 💬
3件: Drug metabolism - other enzymes, Metabolic pathways, Purine metabolism 💬34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
63Myeloablative Preparative Regimen----3件: 62, 65, 284
64Other: Laboratory Biomarker Analysis----21件: 11, 13, 14, 26, 28, 34, 49, 51, 60, 62, 65, 89, 96, 97, 205, 232, 283, 284, 285, 298, 331
65Peripheral Blood Stem Cell Transplantation----12件: 11, 13, 14, 28, 51, 60, 62, 65, 283, 284, 285, 286
66Phosphate1件: Phosphate ion---33件: 2, 3, 6, 11, 12, 13, 15, 28, 36, 46, 49, 51, 53, 60, 62, 65, 70, 78, 81, 83, 90, 96, 97, 164, 235, 238, 256, 276, 283, 284, 285, 286, 299
67Prednisone1件: Prednisone1件: D00473 1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬48件: 2, 6, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
68Radiation therapy----3件: 13, 284, 285
69Radiation: radiation therapy----5件: 34, 60, 65, 284, 285
70Radiation: Total Body Irradiation----7件: 36, 49, 51, 60, 65, 283, 284
71Radiation: total-body irradiation----9件: 28, 51, 60, 62, 65, 96, 283, 284, 285
72Reduced Intensity Preparative Regimen----3件: 62, 65, 284
73Reduced Toxicity Ablative Regimen----3件: 62, 65, 284
74Rimiducid1件: Rimiducid1件: D11195 1件: CASP9 💬35件: Alzheimer disease, Amyotrophic lateral sclerosis, Apoptosis, Apoptosis - multiple species, Colorectal cancer, Endometrial cancer, Epstein-Barr virus infection, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Huntington disease, Influenza A, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Lipid and atherosclerosis, Measles, Non-small cell lung cancer, PI3K-Akt signaling pathway, Pancreatic cancer, Parkinson disease, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platinum drug resistance, Prion disease, Prostate cancer, Small cell lung cancer, Thyroid hormone signaling pathway, Toxoplasmosis, Tuberculosis, VEGF signaling pathway, Viral myocarditis, p53 signaling pathway 💬6件: 19, 60, 65, 284, 285, 326
75Rituximab1件: Rituximab1件: D02994 1件: MS4A1 💬1件: Hematopoietic cell lineage 💬49件: 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
76Rivogenlecleucel----6件: 19, 60, 65, 284, 285, 326
77SOTATERCEPT1件: Sotatercept1件: D09670 1件: ACVR2A 💬4件: Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬2件: 86, 284
78Sotatercept with prednisone boost2件: Prednisone,
Sotatercept
2件: D00473 ,
D09670
2件: ACVR2A,
NR3C1 💬
5件: Cytokine-cytokine receptor interaction, Fluid shear stress and atherosclerosis, Neuroactive ligand-receptor interaction, Signaling pathways regulating pluripotency of stem cells, TGF-beta signaling pathway 💬1件: 284
79SSP-004184 100 mg----1件: 284
80SSP-004184 100 mg Capsule----1件: 284
81SSP-004184 250 mg----1件: 284
82SSP-004184 250 mg Capsule----1件: 284
83SSP-004184 375 mg----1件: 284
84SSP-004184 375 mg Capsule----1件: 284
85SSP-004184 50 mg----1件: 284
86SSP-004184 50 mg Capsule----1件: 284
87SSP-004184 500 mg----1件: 284
88SSP-004184 500 mg Capsule----1件: 284
89SSP-004184AQ 100 mg----1件: 284
90SSP-004184AQ 100 mg Capsule----1件: 284
91SSP-004184AQ 200 mg----1件: 284
92SSP-004184AQ 200 mg Capsule----1件: 284
93SSP-004184AQ 250 mg----1件: 284
94SSP-004184AQ 250 mg Capsule----1件: 284
95SSP-004184AQ 375 mg----1件: 284
96SSP-004184AQ 375 mg Capsule----1件: 284
97SSP-004184AQ 50 mg----1件: 284
98SSP-004184AQ 50 mg Capsule----1件: 284
99Stem Cell Infusion----5件: 28, 60, 65, 284, 285
100Stem Cell Transplant----6件: 19, 20, 60, 65, 164, 284
101Tacrolimus1件: Tacrolimus2件: D00107 ,
D08556
5件: PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬
33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
102Thiotepa1件: Thiotepa1件: D00583 --12件: 13, 19, 20, 28, 51, 60, 65, 85, 96, 164, 284, 285
103Thiotepa--escalated dose1件: Thiotepa1件: D00583 --4件: 19, 20, 65, 284
104Thiotepa--single daily dose1件: Thiotepa1件: D00583 --4件: 19, 20, 65, 284
105Total lymphoid irradiation----3件: 65, 284, 326
106Trifluoperazine1件: Trifluoperazine3件: D00799 ,
D01448 ,
D08636
1件: DRD2 💬8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬2件: 283, 284
107Umbilical Cord Blood Transplantation----5件: 60, 65, 284, 285, 326