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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
10000----1件: 3
22011-2012 seasonal flu vaccine Intramuscular----2件: 3, 113
32011-2012 seasonal flu vaccine Subcutaneous----2件: 3, 113
43,4-Diaminopyridine Phosphate1件: Phosphate ion---1件: 3
54-Aminopyridine1件: Dalfampridine1件: D04127 4件: KCNA4,
KCNC3,
KCND2,
KCND3 💬		4件: Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬2件: 3, 13
64-cholesten-3-one, oxime----2件: 2, 3
74-cholesten-3-one,oxime----1件: 3
8Adipose derived mesenchymal stem cell----1件: 3
9Air----8件: 3, 13, 51, 58, 85, 97, 193, 299
10Air stacking manuever----1件: 3
11AMIFAMPRIDINA----2件: 3, 11
12Amifampridina fosfato----2件: 3, 11
13Amifampridine1件: Amifampridine1件: D10228 4件: KCNA4,
KCNC3,
KCND2,
KCND3 💬		4件: Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬3件: 3, 11, 12
14Amifampridine Phosphate2件: Amifampridine,
Phosphate ion		1件: D10228 4件: KCNA4,
KCNC3,
KCND2,
KCND3 💬		4件: Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬3件: 3, 11, 12
15Amifampridine Phosphate 10 MG Oral Tablet2件: Amifampridine,
Phosphate ion		1件: D10228 4件: KCNA4,
KCNC3,
KCND2,
KCND3 💬		4件: Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬1件: 3
16Apitegromab1件: Apitegromab1件: D11797 1件: MSTN 💬1件: Cytokine-cytokine receptor interaction 💬1件: 3
17AVXS-101----1件: 3
18AVXS-101 (previously known as scAAV9.CB.SMN)----1件: 3
19Biocarn----1件: 3
20Branaplam1件: Branaplam---2件: 3, 8
21Calcium1件: Calcium---30件: 3, 6, 13, 15, 19, 46, 49, 51, 53, 56, 68, 75, 79, 84, 93, 94, 95, 96, 97, 186, 214, 215, 222, 224, 235, 256, 265, 274, 298, 299
22Celecoxib1件: Celecoxib1件: D00567 1件: PTGS2 💬22件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬10件: 2, 3, 34, 46, 70, 89, 107, 161, 171, 271
23Creatine1件: Creatine---16件: 1, 2, 3, 5, 6, 8, 13, 15, 21, 46, 49, 50, 113, 156, 201, 256
24Diagnostic Test: Beck depression inventory fast screen (Questionnaire)----3件: 3, 15, 256
25Diagnostic Test: Borg Scale----3件: 3, 15, 256
26Diagnostic Test: Brief Pain Inventory (BPI) (Questionnaire)----3件: 3, 15, 256
27Diagnostic Test: Fatigue Severity and Disability Scale (FSS) (Questionnaire)----3件: 3, 15, 256
28Diagnostic Test: German Pain Inventory (Questionnaire)----3件: 3, 15, 256
29Diagnostic Test: Handheld Dynamometry (HHD)----3件: 3, 15, 256
30Diagnostic Test: Laboratory assessment: calcium1件: Calcium---3件: 3, 15, 256
31Diagnostic Test: Laboratory assessment: Creatine kinase1件: Creatine---3件: 3, 15, 256
32Diagnostic Test: Laboratory assessment: magnesium1件: Magnesium---3件: 3, 15, 256
33Diagnostic Test: Laboratory assessment: phosphate1件: Phosphate ion---3件: 3, 15, 256
34Diagnostic Test: Laboratory assessment: Vitamin D Level1件: Vitamin D---3件: 3, 15, 256
35Diagnostic Test: Muscle ultrasound----3件: 3, 15, 256
36Diagnostic Test: Pressure pain threshold----4件: 3, 15, 113, 256
37Diagnostic Test: Quick Motor Function Test----4件: 3, 15, 113, 256
38Diagnostic Test: R-PAct (Questionnaire)----3件: 3, 15, 256
39Diagnostic Test: Rotterdam Handicap Scale (RHS) (Questionnaire)----3件: 3, 15, 256
40Diagnostic Test: Six-minute walk test (6MWT)----3件: 3, 15, 256
41Diagnostic Test: Vital signs----3件: 3, 15, 256
42EVRYSDI1件: Risdiplam1件: D11406 1件: SMN2 💬1件: Nucleocytoplasmic transport 💬1件: 3
43Firdapse1件: Amifampridine1件: D10228 4件: KCNA4,
KCNC3,
KCND2,
KCND3 💬		4件: Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬2件: 3, 11
44FIRDAPSE - 10 MG - COMPRESSE - USO ORALE - BLISTER(ALU/PVC/PVDC) 100 X 1 COMPRESSE1件: Amifampridine1件: D10228 4件: KCNA4,
KCNC3,
KCND2,
KCND3 💬		4件: Cortisol synthesis and secretion, Cushing syndrome, Serotonergic synapse, Spinocerebellar ataxia 💬2件: 3, 11
45Genetic: Blood draw for optional genetic exome sequencing----3件: 3, 15, 256
46Genetic: Genetic test: ACE polymorphism----3件: 3, 15, 256
47Genetic: Genetic test: ACTN3 polymorphism----3件: 3, 15, 256
48GH----1件: 3
49GYM329----1件: 3
50HUMAN ANTI-PROMYOSTATIN MONOCLONAL ANTIBODY----1件: 3
51Hydroxyurea1件: Hydroxyurea1件: D00341 1件: RRM2 💬6件: Drug metabolism - other enzymes, Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, p53 signaling pathway 💬8件: 3, 13, 19, 20, 65, 85, 86, 284
52ISIS 396443----1件: 3
53ISIS 396443 (BIIB058)----1件: 3
54ISIS 396443, BIIB058----1件: 3
55Itraconazole1件: Itraconazole1件: D00350 --5件: 3, 65, 96, 227, 299
56Leuprolide1件: Leuprolide1件: D00989 1件: GNRHR 💬2件: GnRH signaling pathway, Neuroactive ligand-receptor interaction 💬5件: 1, 2, 3, 51, 76
57LEVOCARNITINE1件: Levocarnitine3件: D02030 ,
D02176 ,
D04713 		--3件: 3, 53, 97
58LMI070----2件: 3, 8
59Magnesium1件: Magnesium---19件: 3, 6, 11, 13, 15, 46, 64, 70, 93, 97, 166, 225, 235, 256, 284, 291, 296, 297, 298
60Mestinon1件: Pyridostigmine1件: D00487 1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬3件: 3, 6, 11
61Midazolam1件: Midazolam3件: D00550 ,
D00696 ,
D05028 		16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 231, 272, 298
62N.a.----10件: 3, 6, 8, 13, 46, 96, 97, 240, 256, 271
63Nerve Growth Factor1件: Nerve Growth Factor---3件: 3, 53, 90
64Norditropin SimpleXx----5件: 3, 78, 107, 193, 195
65Norditropin SimpleXx 15 mg/1.5 ml1件: Somatotropin1件: D02691 1件: GHR 💬5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬1件: 3
66Nursinersen----1件: 3
67NUSINERSEN1件: Nusinersen1件: D10881 1件: SMN2 💬-1件: 3
68Nusinersen Injectable Product1件: Nusinersen1件: D10881 1件: SMN2 💬-1件: 3
69NUSINERSEN SODIUM1件: Nusinersen1件: D10881 1件: SMN2 💬-1件: 3
70Nusinersen Treatments1件: Nusinersen1件: D10881 1件: SMN2 💬-1件: 3
71OAV101----1件: 3
72Okrido----1件: 3
73Okrido 6mg/mL oral solution----1件: 3
74Olesoxime----2件: 2, 3
75ONASEMNOGENE ABEPARVOVEC1件: Onasemnogene abeparvovec1件: D11559 1件: SMN1 💬-1件: 3
76Onasemnogene Abeparvovec-xioi1件: Onasemnogene abeparvovec1件: D11559 1件: SMN1 💬-1件: 3
77Orfiril Saft----1件: 3
78Other: Monthly assessments of functional motor abilities by a trained therapist----1件: 3
79Other: Prospective observational registry----1件: 3
80PARACETAMOL1件: Acetaminophen1件: D00217 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬6件: 3, 6, 13, 35, 46, 49
81Paracetamol 120Mg/5mL Oral Suspension1件: Acetaminophen1件: D00217 2件: PTGS1,
PTGS2 💬		23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬1件: 3
82PHENYLBUTYRATE1件: Phenylbutyric acid---12件: 2, 3, 6, 8, 15, 93, 94, 244, 251, 297, 299, 338
83Phosphate1件: Phosphate ion---33件: 2, 3, 6, 11, 12, 13, 15, 28, 36, 46, 49, 51, 53, 60, 62, 65, 70, 78, 81, 83, 90, 96, 97, 164, 235, 238, 256, 276, 283, 284, 285, 286, 299
84Placebo----27件: 3, 5, 6, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
85PREDNISOLONE1件: Prednisolone8件: D00472 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02156 ,
D03301 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
86PREDNISOLONE SODIUM PHOSPHATE2件: Phosphate ion,
Prednisolone		8件: D00472 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02156 ,
D03301 		1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬3件: 3, 13, 97
87Previously termed sc.AAV9.CB.SMN and AVXS-101----1件: 3
88Pyridostigmine1件: Pyridostigmine1件: D00487 1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬4件: 3, 6, 11, 256
89Pyridostigmine Bromide1件: Pyridostigmine1件: D00487 1件: ACHE 💬2件: Cholinergic synapse, Glycerophospholipid metabolism 💬3件: 3, 6, 256
90RELDESEMTIV1件: Reldesemtiv1件: D11363 1件: TNNC2 💬1件: Calcium signaling pathway 💬2件: 2, 3
91Reldesemtiv 150 mg1件: Reldesemtiv1件: D11363 1件: TNNC2 💬1件: Calcium signaling pathway 💬1件: 3
92Reldesemtiv 450 mg1件: Reldesemtiv1件: D11363 1件: TNNC2 💬1件: Calcium signaling pathway 💬1件: 3
93RILUZOLE1件: Riluzole1件: D00775 14件: GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		23件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
94Risdiplam1件: Risdiplam1件: D11406 1件: SMN2 💬1件: Nucleocytoplasmic transport 💬1件: 3
95RO6885247----1件: 3
96RO6885247/F02----1件: 3
97RO6885247/F03----1件: 3
98RO7034067----1件: 3
99RO7034067 / F12----1件: 3
100RO7034067 / F13----1件: 3
101RO7034067/F06 + solvente (RO----1件: 3
102RO7034067/F06 with solvent (RO7034067/F08)----1件: 3
103RO7034067/F07 + solvente (RO----1件: 3
104RO7034067/F07 with solvent (RO7034067/F09)----1件: 3
105RO7034067/F12----1件: 3
106RO7034067/F13----1件: 3
107RO7090919----1件: 3
108RO7204239----1件: 3
109RO7204239/F01-01----1件: 3
110RVG 03820----1件: 3
111Salbutamol1件: Salbutamol1件: D02147 1件: ADRB2 💬9件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, cAMP signaling pathway, cGMP-PKG signaling pathway 💬9件: 3, 11, 49, 85, 86, 111, 228, 256, 299
112Sesame oil1件: Sesame oil1件: D03314 --1件: 3
113SESAME OIL, REFINED1件: Sesame oil1件: D03314 --1件: 3
114Sham Procedure----1件: 3
115SMART----1件: 3
116Sodium phenylbutyrate1件: Phenylbutyric acid---4件: 2, 3, 8, 251
117Sodium phenylbutyrate (NaPB)1件: Phenylbutyric acid---1件: 3
118Somatotropin1件: Somatotropin1件: D02691 1件: GHR 💬5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬4件: 3, 65, 78, 236
119Somatropin1件: Somatotropin1件: D02691 1件: GHR 💬5件: Cytokine-cytokine receptor interaction, Growth hormone synthesis, secretion and action, JAK-STAT signaling pathway, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway 💬19件: 2, 3, 19, 46, 65, 74, 75, 78, 96, 107, 113, 187, 193, 195, 238, 265, 274, 276, 299
120Spinraza1件: Nusinersen1件: D10881 1件: SMN2 💬-1件: 3
121SRK-015----1件: 3
122Sulfate1件: Sulfate ion---27件: 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 79, 85, 86, 96, 111, 218, 222, 226, 265, 296, 297, 299
123Survival of Motor Neuron 2 (SMN2) Splicing Modulator Antisense Oligonucleotide----1件: 3
124Testosterone1件: Testosterone6件: D00075 ,
D00957 ,
D00958 ,
D00959 ,
D06085 ,
D06087 		1件: AR 💬4件: Chemical carcinogenesis - receptor activation, Oocyte meiosis, Pathways in cancer, Prostate cancer 💬9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
125TRO196221件: TRO19622---3件: 2, 3, 13
126Valproate1件: Valproic acid1件: D00399 7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		17件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬6件: 2, 3, 90, 102, 233, 256
127VALPROATE SODIUM1件: Valproic acid1件: D00399 7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		17件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬1件: 3
128Valproate, Levocarnitine2件: Levocarnitine,
Valproic acid		4件: D00399 ,
D02030 ,
D02176 ,
D04713 		7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		17件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬1件: 3
129Valproic Acid1件: Valproic acid1件: D00399 7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		17件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬10件: 3, 5, 26, 34, 65, 89, 90, 222, 256, 331
130Valproic Acid (VPA)1件: Valproic acid1件: D00399 7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		17件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬1件: 3
131Valproic Acid and Levocarnitine2件: Levocarnitine,
Valproic acid		4件: D00399 ,
D02030 ,
D02176 ,
D04713 		7件: ABAT,
ALDH5A1,
CACNA1G,
CACNA1H,
CACNA1I,
GAD1,
GAD2 💬		17件: Alanine, aspartate and glutamate metabolism, Aldosterone synthesis and secretion, Butanoate metabolism, Calcium signaling pathway, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, GABAergic synapse, GnRH secretion, MAPK signaling pathway, Metabolic pathways, Propanoate metabolism, Taurine and hypotaurine metabolism, Type I diabetes mellitus, Type II diabetes mellitus, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬1件: 3
132Vitamin D1件: Vitamin D---24件: 3, 13, 15, 19, 41, 43, 44, 46, 49, 50, 68, 93, 95, 96, 97, 98, 179, 222, 228, 235, 256, 274, 298, 299
133VOLMAX*30CPR 4MG R.P.----1件: 3
134VPA----1件: 3
135Zolgensma1件: Onasemnogene abeparvovec1件: D11559 1件: SMN1 💬-1件: 3
136Zolgensma 2 x 1013 vector genomes/mL solution for infusion1件: Onasemnogene abeparvovec1件: D11559 1件: SMN1 💬-1件: 3