Drug Description in Trials / DrugBank / KEGG DRUG

  

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No. DrugBank 薬物名（臨床試験情報から抽出） KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 ACR-16 0件: ---1件: 8
2 Alprazolam 1件: Alprazolam1件: D00225 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 8, 75
3 Amantadine 3件: Amantadine; AMANTADINE HYDROCHLORIDE; GOCOVRI2件: D00777 ,
D07441 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬4件: 6, 8, 13, 127
4 Atomoxetine 2件: Atomoxetine; Strattera2件: D02574 ,
D07473 		1件: SLC6A2 💬1件: Synaptic vesicle cycle 💬4件: 6, 8, 13, 17
5 Bevantolol 1件: Bevantolol---1件: 8
6 Biotin 4件: Biotin; Biotina; D-BIOTIN; Vitamin B71件: D00029 --5件: 2, 8, 10, 13, 20
7 Branaplam 1件: Branaplam---2件: 3, 8
8 Bupropion 2件: Bupropion; Bupropion Hydrochloride3件: D00817 ,
D07591 ,
D07938 		2件: SLC6A2,
SLC6A3 💬		7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬5件: 8, 18, 21, 96, 171
9 Cannabidiol 3件: CANNABIDIOL; Epidyolex; Sativex1件: D10915 2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬19件: 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
10 Citalopram 1件: Citalopram2件: D00822 ,
D07704 		1件: SLC6A4 💬2件: Serotonergic synapse, Synaptic vesicle cycle 💬7件: 6, 8, 13, 18, 46, 98, 127
11 Creatine 1件: Creatine---16件: 1, 2, 3, 5, 6, 8, 13, 15, 21, 46, 49, 50, 113, 156, 201, 256
12 Cysteamine 8件: 2-aminoethanethiol; Beta-Mercaptoethylamine; CYSTADROPS; CYSTAGON; CYSTEAMINE; Mercaptamina; Mercaptamine; PROCYSBI2件: D03634 ,
D03635 		--4件: 8, 19, 21, 299
13 Deutetrabenazine 1件: Deutetrabenazine1件: D10701 1件: SLC18A2 💬7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬1件: 8
14 Dextromethorphan 4件: Dextromethorphan; DEXTROMETHORPHAN HYDROBROMIDE; Dextrometorfano; Nuedexta3件: D00848 ,
D03742 ,
D03744 		6件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156
15 Digoxin 1件: Digoxin1件: D00298 4件: ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬		18件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 8, 46, 210
16 Dronabinol 4件: DELTA-9-TETRAHYDROCANNABINOL; DRONABINOL; SATIVEX; Tetrahydrocannabinol1件: D00306 2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬8件: 2, 8, 13, 36, 46, 96, 271, 298
17 Epigallocatechin 1件: Epigallocatechin---5件: 8, 13, 28, 85, 113
18 Epigallocatechin gallate 2件: EGCG; Epigallocatechin gallate---9件: 6, 8, 13, 17, 28, 85, 113, 206, 299
19 Fenofibrate 1件: Fenofibrate1件: D00565 1件: PPARA 💬10件: Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬5件: 8, 79, 93, 94, 265
20 Fludeoxyglucose (18F) 3件: 18F-FDG; Fludeoxyglucose; Fludeoxyglucose F 18---14件: 5, 6, 7, 8, 13, 34, 41, 46, 53, 84, 85, 96, 127, 300
21 GSK-356278 0件: ---1件: 8
22 Haloperidol 1件: Haloperidol2件: D00136 ,
D01898 		1件: DRD2 💬8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 8
23 Icosapent 2件: Eicosapentaenoic Acid; Icosapent1件: D08061 --11件: 8, 46, 48, 49, 96, 97, 113, 296, 297, 301, 338
24 Icosapent ethyl 2件: Ethyl-EPA; Icosapent1件: D01892 --2件: 8, 296
25 Idebenone 2件: Idebenone; Raxone1件: D01750 --6件: 6, 8, 13, 18, 113, 302
26 Indopan 0件: ---4件: 8, 46, 97, 321
27 Ketoconazole 2件: Ketoconazole; NIZORAL1件: D00351 1件: CYP17A1 💬6件: Cortisol synthesis and secretion, Cushing syndrome, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling pathway, Steroid hormone biosynthesis 💬3件: 8, 13, 75
28 Laquinimod 1件: Laquinimod---4件: 8, 13, 49, 96
29 Latrepirdine 2件: Dimebon; Latrepirdine1件: D09917 6件: ACHE,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		22件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Glycerophospholipid metabolism, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬1件: 8
30 LAX-101 1件: LAX-101---1件: 8
31 Lithium citrate 2件: Lithium; LITHIUM CITRATE1件: D04749 --5件: 2, 5, 6, 7, 8
32 Manganese citrate 1件: Release---12件: 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299
33 Melatonin 2件: Circadin; Melatonin1件: D08170 2件: MTNR1A,
MTNR1B 💬		2件: Circadian entrainment, Neuroactive ligand-receptor interaction 💬12件: 6, 8, 13, 37, 46, 49, 90, 97, 144, 145, 149, 202
34 Memantine 3件: Ebixa; Memantine; MEMANTINE HYDROCHLORIDE2件: D04905 ,
D08174 		5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬7件: 2, 6, 8, 13, 49, 127, 205
35 Metformin 5件: Metformin; Metformin HCl; Metformin Hydrochloride; Metformina; Metformine2件: D00944 ,
D04966 		2件: PRKAA1,
PRKAA2 💬		20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
36 Minocycline 3件: Minocycline; MINOCYCLINE HYDROCHLORIDE; Minomycin2件: D00850 ,
D05045 		--14件: 2, 6, 8, 13, 46, 84, 85, 90, 94, 162, 201, 206, 280, 299
37 Neflamapimod 1件: Neflamapimod1件: D10959 4件: MAPK11,
MAPK12,
MAPK13,
MAPK14 💬		62件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Alcoholic liver disease, Amyotrophic lateral sclerosis, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Dopaminergic synapse, Endocrine resistance, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hepatitis B, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, IL-17 signaling pathway, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Leukocyte transendothelial migration, Lipid and atherosclerosis, MAPK signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Oocyte meiosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Platelet activation, Prion disease, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rap1 signaling pathway, Relaxin signaling pathway, Retrograde endocannabinoid signaling, Salmonella infection, Shigellosis, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Thermogenesis, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, VEGF signaling pathway, Yersinia infection 💬1件: 8
38 Nilotinib 2件: NILOTINIB; Tasigna1件: D08953 4件: ABL1,
KIT,
PDGFRA,
PDGFRB 💬		33件: Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬5件: 6, 8, 34, 51, 86
39 Olanzapine 2件: Olanzapine; Zyprexa2件: D00454 ,
D06623 		11件: ADRA1A,
ADRA1B,
ADRA1D,
DRD2,
DRD3,
DRD4,
HRH1,
HTR2A,
HTR2B,
HTR2C,
HTR6 💬		16件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Salivary secretion, Serotonergic synapse, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 2, 8
40 Omeprazole 5件: Losec; Omeprazol; Omeprazole; Omeprazole 20 mg; OMEPRAZOLE MAGNESIUM4件: D00455 ,
D01207 ,
D05259 ,
D05261 		2件: ATP4A,
ATP4B 💬		4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
41 Phenylbutyric acid 4件: 4-phenylbutyrate; Pheburane; Phenylbutyrate; Sodium phenylbutyrate---14件: 2, 3, 6, 8, 15, 21, 93, 94, 231, 244, 251, 297, 299, 338
42 Phosphorus 2件: Phosphorous; Phosphorus---3件: 8, 58, 238
43 Pridopidine 1件: Pridopidine1件: D09953 1件: DRD2 💬8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬3件: 2, 6, 8
44 Quinidine 4件: Nuedexta; Quinidina; Quinidine; Quinidine Sulfate4件: D00642 ,
D00643 ,
D02272 ,
D08458 		5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬3件: 2, 8, 13
45 Ramelteon 2件: Ramelteon; ROZEREM1件: D02689 2件: MTNR1A,
MTNR1B 💬		2件: Circadian entrainment, Neuroactive ligand-receptor interaction 💬3件: 6, 8, 46
46 Resveratrol 1件: Resveratrol---6件: 2, 8, 18, 89, 113, 299
47 Rilmenidine 2件: HYPERIUM; Rilmenidine1件: D08482 3件: ADRA2A,
ADRA2B,
ADRA2C 💬		2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬1件: 8
48 Riluzole 2件: Rilutek; Riluzole1件: D00775 14件: GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬		23件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
49 Risperidone 1件: Risperidone1件: D00426 2件: DRD2,
HTR2A 💬		11件: Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬5件: 8, 156, 179, 187, 206
50 Rolipram 1件: Rolipram1件: D01783 4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬		5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬2件: 8, 13
51 Selisistat 1件: Selisistat---1件: 8
52 Tetrabenazine 2件: Tetrabenazine; Xenazine1件: D08575 1件: SLC18A2 💬7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬1件: 8
53 Thiamine 2件: Thiamine; Vitamin B11件: D08580 --5件: 8, 13, 93, 145, 265
54 Tiapride 0件: 1件: D08590 1件: DRD2 💬8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 8
55 Triheptanoin 1件: TRIHEPTANOIN1件: D11465 --10件: 2, 8, 65, 149, 156, 248, 256, 257, 317, 324
56 Ubidecarenone 3件: Coenzyme Q-10; Coenzyme Q10; CoQ101件: D01065 --13件: 2, 5, 6, 8, 10, 18, 46, 57, 86, 113, 193, 214, 215
57 Ubiquinol 1件: Ubiquinol---3件: 6, 8, 17
58 Ursodeoxycholic acid 4件: UDCA; Ursodeoxycholic acid; Ursodiol; Ursofalk1件: D00734 1件: NR1H4 💬1件: Bile secretion 💬14件: 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299
59 Valbenazine 1件: Valbenazine1件: D10675 1件: SLC18A2 💬7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬1件: 8
60 Warfarin 2件: Warfarin; Warfarin Sodium3件: D00564 ,
D01280 ,
D08682 		2件: NQO1,
VKORC1 💬		7件: Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97