Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	DHFR	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
2	DHFR	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D02115	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
3	DHODH	3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	D00749	Leflunomide	12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
4	DHFR2	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
5	DHFR2	5件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors, A ...	D02115	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
6	FCER1A	4件: Sphingolipid signaling pathway, Phospholipase D signaling pathway, Fc epsilon RI signaling pathw ...	D05251	Omalizumab	7件: 46, 53, 65, 98, 162, 226, 299
7	ABL1	11件: ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signalin ...	D01441	Imatinib	12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
8	ABL1	11件: ErbB signaling pathway, Ras signaling pathway, Cell cycle, Axon guidance, Neurotrophin signalin ...	D08066	Imatinib	12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
9	NR3C1	1件: Neuroactive ligand-receptor interaction	D00292	Dexamethasone	7件: 162, 222, 235, 257, 283, 296, 299
10	NR3C1	1件: Neuroactive ligand-receptor interaction	D00385	Triamcinolone	3件: 162, 226, 298

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