Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	ADRB2	9件: Calcium signaling pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, Neuroactive ligan ...	D02147	Salbutamol	14件: 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299
2	CYP19A1	3件: Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis	D00964	Letrozole	2件: 81, 89
3	ABAT	7件: Alanine, aspartate and glutamate metabolism, Valine, leucine and isoleucine degradation, beta-Al ...	D00399	Valproic acid	17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
4	EGFR	48件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB s ...	D03455	Cetuximab	5件: 34, 51, 86, 89, 331
5	FGFR1	16件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathwa ...	D10481	Nintedanib	5件: 51, 85, 89, 227, 228
6	FGFR3	13件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 ...	D10481	Nintedanib	5件: 51, 85, 89, 227, 228
7	FGFR2	13件: EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 ...	D10481	Nintedanib	5件: 51, 85, 89, 227, 228
8	FLT1	9件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway ...	D10481	Nintedanib	5件: 51, 85, 89, 227, 228
9	FLT4	8件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway ...	D10481	Nintedanib	5件: 51, 85, 89, 227, 228
10	MTOR	51件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 ...	D00753	Sirolimus	41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 9 ...

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