Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	CDK4	22件: Endocrine resistance, p53 signaling pathway, PI3K-Akt signaling pathway, Tight junction, T cell ...	D10688	Abemaciclib	1件: 34
2	CDK6	19件: p53 signaling pathway, PI3K-Akt signaling pathway, Cushing syndrome, Hepatitis C, Measles, Huma ...	D10688	Abemaciclib	1件: 34
3	CRHR1	3件: Neuroactive ligand-receptor interaction, Long-term depression, Cushing syndrome	D03592	Corticorelin ovine triflutate	1件: 75
4	CRHR1	3件: Neuroactive ligand-receptor interaction, Long-term depression, Cushing syndrome	D03905	Corticorelin	2件: 75, 205
5	CRHR2	2件: Neuroactive ligand-receptor interaction, Cushing syndrome	D03592	Corticorelin ovine triflutate	1件: 75
6	CRHR2	2件: Neuroactive ligand-receptor interaction, Cushing syndrome	D03905	Corticorelin	2件: 75, 205
7	CYP11B1	3件: Steroid hormone biosynthesis, Metabolic pathways, Cushing syndrome	D00410	Metyrapone	2件: 75, 193
8	CYP11B1	3件: Steroid hormone biosynthesis, Metabolic pathways, Cushing syndrome	D05019	Metyrapone	2件: 75, 193
9	CYP17A1	5件: Steroid hormone biosynthesis, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling p ...	D00351	Ketoconazole	3件: 8, 13, 75
10	AGTR1	8件: Phospholipase D signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth musc ...	D00150	Angiotensin II	7件: 17, 19, 46, 66, 86, 222, 224

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