Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	MAPK14	36件: MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, ...	D09639	Losmapimod	2件: 113, 222
2	MAPK14	36件: MAPK signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Oocyte meiosis, ...	D10959	Neflamapimod	1件: 8
3	ITGA4	4件: PI3K-Akt signaling pathway, Leukocyte transendothelial migration, Regulation of actin cytoskelet ...	D06590	Firategrast	1件: 13
4	ITGA4	4件: PI3K-Akt signaling pathway, Leukocyte transendothelial migration, Regulation of actin cytoskelet ...	D06886	Natalizumab	6件: 13, 15, 25, 46, 63, 96
5	ITGA4	4件: PI3K-Akt signaling pathway, Leukocyte transendothelial migration, Regulation of actin cytoskelet ...	D08083	Vedolizumab	3件: 94, 96, 97
6	ITGA4	4件: PI3K-Akt signaling pathway, Leukocyte transendothelial migration, Regulation of actin cytoskelet ...	D10540	Abrilumab	2件: 96, 97
7	ITGAL	9件: Rap1 signaling pathway, Neutrophil extracellular trap formation, Natural killer cell mediated cy ...	D03959	Efalizumab	9件: 11, 13, 37, 46, 49, 53, 61, 95, 96
8	PIK3CA	48件: Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Ph ...	D11158	Leniolisib	2件: 53, 65
9	PIK3CB	48件: Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Ph ...	D11158	Leniolisib	2件: 53, 65
10	PIK3CD	48件: Metabolic pathways, Platinum drug resistance, Ras signaling pathway, Rap1 signaling pathway, Ph ...	D11158	Leniolisib	2件: 53, 65

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