Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	MTOR	19件: Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevit ...	D00753	Sirolimus	41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 9 ...
2	MTOR	19件: Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevit ...	D02714	Everolimus	9件: 34, 67, 89, 96, 137, 157, 158, 228, 277
3	MTOR	19件: Phospholipase D signaling pathway, mTOR signaling pathway, PI3K-Akt signaling pathway, Longevit ...	D06068	Temsirolimus	4件: 13, 34, 89, 331
4	HDAC1	8件: Longevity regulating pathway- multiple species, Notch signaling pathway, Neutrophil extracellula ...	D06320	Vorinostat	3件: 19, 75, 96
5	HDAC2	8件: Longevity regulating pathway- multiple species, Notch signaling pathway, Neutrophil extracellula ...	D06320	Vorinostat	3件: 19, 75, 96
6	IGF1R	16件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Oocyte meiosis, mTOR sig ...	D03297	Mecasermin	6件: 65, 78, 96, 168, 265, 299
7	IGF1R	16件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Oocyte meiosis, mTOR sig ...	D04870	Mecasermin	6件: 65, 78, 96, 168, 265, 299
8	IGF1R	16件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Oocyte meiosis, mTOR sig ...	D09680	Teprotumumab	1件: 51
9	IGF1R	16件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Oocyte meiosis, mTOR sig ...	D09925	Linsitinib	1件: 232
10	INSR	12件: MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Phospholipase D signalin ...	D00085	Insulin human	2件: 96, 156

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