Target Gene/Pathway Pathway / Gene


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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 TPH2 4件: Tryptophan metabolism, Folate biosynthesis, Metabolic pathways, Serotonergic synapse D09973 Telotristat 1件: 97
2 DHFR 3件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
3 DHFR 3件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
4 DHFR2 3件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
5 DHFR2 3件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
6 ALPL 3件: Thiamine metabolism, Folate biosynthesis, Metabolic pathways D10595 Asfotase alfa 1件: 172
7 PAH 4件: Phenylalanine metabolism, Phenylalanine, tyrosine and tryptophan biosynthesis, Folate biosynthesis, Metabolic pathways D11077 Pegvaliase 1件: 240
8 TPH1 4件: Tryptophan metabolism, Folate biosynthesis, Metabolic pathways, Serotonergic synapse D09973 Telotristat 1件: 97