Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	DHFR	4件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
2	DHFR	4件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors	D02115	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
3	DHODH	3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	D00749	Leflunomide	12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
4	DHODH	3件: Pyrimidine metabolism, Metabolic pathways, Biosynthesis of cofactors	D10172	Teriflunomide	3件: 13, 25, 26
5	NQO1	7件: Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofacto ...	D00564	Warfarin	13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
6	NQO1	7件: Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofacto ...	D01280	Warfarin	13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
7	NQO1	7件: Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, Biosynthesis of cofacto ...	D08682	Warfarin	13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
8	DHFR2	4件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors	D00142	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
9	DHFR2	4件: One carbon pool by folate, Folate biosynthesis, Metabolic pathways, Biosynthesis of cofactors	D02115	Methotrexate	38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, ...
10	ALAS1	4件: Glycine, serine and threonine metabolism, Porphyrin metabolism, Metabolic pathways, Biosynthesis ...	D10003	Hemin	1件: 254

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