Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	CDK4	24件: Endocrine resistance, p53 signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, T ...	D10688	Abemaciclib	1件: 34
2	CDK6	21件: p53 signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Cushing syndrome, Hepat ...	D10688	Abemaciclib	1件: 34
3	MAPK14	57件: Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D09639	Losmapimod	2件: 113, 222
4	MAPK14	57件: Endocrine resistance, MAPK signaling pathway, Rap1 signaling pathway, FoxO signaling pathway, S ...	D10959	Neflamapimod	1件: 8
5	MTOR	42件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 ...	D00753	Sirolimus	41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 9 ...
6	MTOR	42件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 ...	D02714	Everolimus	9件: 34, 67, 89, 96, 137, 157, 158, 228, 277
7	MTOR	42件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 ...	D06068	Temsirolimus	4件: 13, 34, 89, 331
8	HLA-A	15件: Endocytosis, Phagosome, Cellular senescence, Natural killer cell mediated cytotoxicity, Type I ...	D04318	Glatiramer	4件: 2, 13, 96, 156
9	HLA-B	15件: Endocytosis, Phagosome, Cellular senescence, Natural killer cell mediated cytotoxicity, Type I ...	D04318	Glatiramer	4件: 2, 13, 96, 156
10	HLA-C	15件: Endocytosis, Phagosome, Cellular senescence, Natural killer cell mediated cytotoxicity, Type I ...	D04318	Glatiramer	4件: 2, 13, 96, 156

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