Target Gene/Pathway Pathway / Gene

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No.	KEGG GENES	KEGG PATHWAY	KEGG DRUG	DrugBank	指定難病告示番号
1	MAPK14	24件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathw ...	D09639	Losmapimod	2件: 113, 222
2	MAPK14	24件: Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathw ...	D10959	Neflamapimod	1件: 8
3	IL1A	5件: Type I diabetes mellitus, Prion disease, Pertussis, Tuberculosis, Rheumatoid arthritis	D01583	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
4	IL1A	5件: Type I diabetes mellitus, Prion disease, Pertussis, Tuberculosis, Rheumatoid arthritis	D06635	Rilonacept	4件: 51, 106, 107, 266
5	IL1A	5件: Type I diabetes mellitus, Prion disease, Pertussis, Tuberculosis, Rheumatoid arthritis	D11253	Bermekimab	1件: 51
6	IL1B	11件: Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I ...	D01583	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
7	IL1B	11件: Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I ...	D06635	Rilonacept	4件: 51, 106, 107, 266
8	IL1B	11件: Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I ...	D09315	Canakinumab	10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
9	IL1B	11件: Toll-like receptor signaling pathway, Th17 cell differentiation, TNF signaling pathway, Type I ...	D09911	Gevokizumab	4件: 41, 50, 56, 269
10	IL6	12件: Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, Toll ...	D01583	Pirfenidone	11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228

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