Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 EGFR 7件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D01977 Gefitinib 1件: 75
2 EGFR 7件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D03455 Cetuximab 5件: 34, 51, 86, 89, 331
3 EGFR 7件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D04023 Erlotinib 1件: 94
4 EGFR 7件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D04024 Lapatinib 3件: 34, 74, 75
5 EGFR 7件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D07907 Erlotinib 1件: 94
6 EGFR 7件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D08108 Lapatinib 3件: 34, 74, 75
7 EGFR 7件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D11251 Icotinib 1件: 34
8 EGFR 7件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Proteoglycans in cancer, Prostate cancer D11772 Tesevatinib 1件: 67
9 ERBB2 3件: Tight junction, Proteoglycans in cancer, Prostate cancer D04024 Lapatinib 3件: 34, 74, 75
10 ERBB2 3件: Tight junction, Proteoglycans in cancer, Prostate cancer D08108 Lapatinib 3件: 34, 74, 75
11 ERBB2 3件: Tight junction, Proteoglycans in cancer, Prostate cancer D11772 Tesevatinib 1件: 67
12 FGFR1 7件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Proteoglycans in cancer, Prostate cancer D10481 Nintedanib 5件: 51, 85, 89, 227, 228
13 FGFR1 7件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Thermogenesis, Regulation of actin cytoskeleton, Proteoglycans in cancer, Prostate cancer D11589 Infigratinib 1件: 276
14 FGFR2 5件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Prostate cancer D05338 Palifermin 5件: 13, 36, 38, 39, 65
15 FGFR2 5件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Prostate cancer D10481 Nintedanib 5件: 51, 85, 89, 227, 228
16 FGFR2 5件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Regulation of actin cytoskeleton, Prostate cancer D11589 Infigratinib 1件: 276
17 MTOR 8件: Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Proteoglycans in cancer, Prostate cancer D00753 Sirolimus 41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
18 MTOR 8件: Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Proteoglycans in cancer, Prostate cancer D02714 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277
19 MTOR 8件: Th17 cell differentiation, Thermogenesis, Thyroid hormone signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Proteoglycans in cancer, Prostate cancer D06068 Temsirolimus 4件: 13, 34, 89, 331
20 IGF1R 6件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D03297 Mecasermin 6件: 65, 78, 96, 168, 265, 299
21 IGF1R 6件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D04870 Mecasermin 6件: 65, 78, 96, 168, 265, 299
22 IGF1R 6件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D09680 Teprotumumab 1件: 51
23 IGF1R 6件: Ras signaling pathway, Rap1 signaling pathway, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer, Proteoglycans in cancer, Prostate cancer D09925 Linsitinib 1件: 232
24 AR 1件: Prostate cancer D00075 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
25 AR 1件: Prostate cancer D00289 Danazol 5件: 60, 63, 64, 65, 285
26 AR 1件: Prostate cancer D00444 Stanozolol 1件: 60
27 AR 1件: Prostate cancer D00462 Oxandrolone 2件: 211, 285
28 AR 1件: Prostate cancer D00586 Flutamide 1件: 81
29 AR 1件: Prostate cancer D00955 Nandrolone decanoate 2件: 60, 85
30 AR 1件: Prostate cancer D00957 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
31 AR 1件: Prostate cancer D00958 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
32 AR 1件: Prostate cancer D00958 Testosterone enanthate 2件: 13, 113
33 AR 1件: Prostate cancer D00959 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
34 AR 1件: Prostate cancer D00959 Testosterone propionate 1件: 113
35 AR 1件: Prostate cancer D03338 Calusterone 3件: 2, 46, 71
36 AR 1件: Prostate cancer D06085 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
37 AR 1件: Prostate cancer D06087 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
38 AR 1件: Prostate cancer D06087 Testosterone undecanoate 2件: 13, 60
39 AR 1件: Prostate cancer D08250 Nandrolone 2件: 60, 85
40 AR 1件: Prostate cancer D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
41 AR 1件: Prostate cancer D08573 Testosterone decanoate 1件: 113
42 AR 1件: Prostate cancer D08574 Testosterone phenylpropionate 1件: 113
43 NFKB1 18件: Ras signaling pathway, Sphingolipid signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis, Prostate cancer, Small cell lung cancer D01146 Iguratimod 4件: 46, 51, 53, 271
44 PDGFRA 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D01441 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
45 PDGFRA 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D06402 Sunitinib 2件: 28, 34
46 PDGFRA 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08066 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
47 PDGFRA 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08552 Sunitinib 2件: 28, 34
48 PDGFRA 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08953 Nilotinib 5件: 6, 8, 34, 51, 86
49 PDGFRA 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D10481 Nintedanib 5件: 51, 85, 89, 227, 228
50 PDGFRB 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D03658 Dasatinib 2件: 51, 85
51 PDGFRB 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D06272 Sorafenib 2件: 34, 86
52 PDGFRB 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D06402 Sunitinib 2件: 28, 34
53 PDGFRB 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D06414 Dasatinib 2件: 51, 85
54 PDGFRB 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08524 Sorafenib 2件: 34, 86
55 PDGFRB 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08552 Sunitinib 2件: 28, 34
56 PDGFRB 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D08953 Nilotinib 5件: 6, 8, 34, 51, 86
57 PDGFRB 4件: Ras signaling pathway, Rap1 signaling pathway, Regulation of actin cytoskeleton, Prostate cancer D10481 Nintedanib 5件: 51, 85, 89, 227, 228
58 PIK3CA 22件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
59 PIK3CB 22件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
60 PIK3CD 22件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11158 Leniolisib 2件: 53, 65
61 PIK3CD 22件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Regulation of lipolysis in adipocytes, Relaxin signaling pathway, Type II diabetes mellitus, Spinocerebellar ataxia, Shigellosis, Salmonella infection, Yersinia infection, Viral carcinogenesis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Small cell lung cancer D11437 Parsaclisib 3件: 35, 53, 61
62 MAP2K1 19件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D09666 Selumetinib 1件: 34
63 MAP2K1 19件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10175 Trametinib 4件: 2, 34, 279, 280
64 MAP2K1 19件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10405 Cobimetinib 1件: 280
65 MAP2K1 19件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10604 Binimetinib 1件: 34
66 MAP2K2 17件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D09666 Selumetinib 1件: 34
67 MAP2K2 17件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10175 Trametinib 4件: 2, 34, 279, 280
68 MAP2K2 17件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10405 Cobimetinib 1件: 280
69 MAP2K2 17件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, Toll-like receptor signaling pathway, T cell receptor signaling pathway, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Yersinia infection, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10604 Binimetinib 1件: 34
70 RAF1 16件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer D06272 Sorafenib 2件: 34, 86
71 RAF1 16件: Ras signaling pathway, Rap1 signaling pathway, Sphingolipid signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway, Signaling pathways regulating pluripotency of stem cells, T cell receptor signaling pathway, Serotonergic synapse, Regulation of actin cytoskeleton, Thyroid hormone signaling pathway, Relaxin signaling pathway, Salmonella infection, Tuberculosis, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer D08524 Sorafenib 2件: 34, 86
72 BCL2 8件: Sphingolipid signaling pathway, Protein processing in endoplasmic reticulum, Shigellosis, Salmonella infection, Toxoplasmosis, Tuberculosis, Prostate cancer, Small cell lung cancer D10679 Venetoclax 1件: 28
73 RELA 18件: Ras signaling pathway, Sphingolipid signaling pathway, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, TNF signaling pathway, Relaxin signaling pathway, Shigellosis, Salmonella infection, Yersinia infection, Toxoplasmosis, Tuberculosis, Transcriptional misregulation in cancer, Viral carcinogenesis, Prostate cancer, Small cell lung cancer D12181 Edasalonexent 1件: 113
74 SRD5A2 2件: Steroid hormone biosynthesis, Prostate cancer D00321 Finasteride 1件: 6
75 SRD5A2 2件: Steroid hormone biosynthesis, Prostate cancer D03820 Dutasteride 2件: 1, 2
76 BRAF 8件: Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D06272 Sorafenib 2件: 34, 86
77 BRAF 8件: Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D08524 Sorafenib 2件: 34, 86
78 BRAF 8件: Rap1 signaling pathway, Vascular smooth muscle contraction, Serotonergic synapse, Regulation of actin cytoskeleton, Proteoglycans in cancer, Renal cell carcinoma, Prostate cancer, Thyroid cancer D10064 Dabrafenib 1件: 34
79 IL1R2 2件: Transcriptional misregulation in cancer, Prostate cancer D02934 Anakinra 19件: 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
80 CASP9 7件: VEGF signaling pathway, Thyroid hormone signaling pathway, Toxoplasmosis, Tuberculosis, Prostate cancer, Small cell lung cancer, Viral myocarditis D11195 Rimiducid 6件: 19, 60, 65, 284, 285, 326