Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related 		KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Adipocytokine signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
2 Adipocytokine signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
3 AGE-RAGE signaling pathway in diabetic complications 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
4 Alcoholic liver disease 💬
 3件: ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole 1件: 301 💬
5 Alcoholic liver disease 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
6 Alcoholic liver disease 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
7 AMPK signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
8 AMPK signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
9 Apelin signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
10 Apelin signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
11 Autophagy - animal 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
12 Autophagy - animal 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
13 Bladder cancer 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
14 Calcium signaling pathway 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
15 cGMP-PKG signaling pathway 💬
 1件: PDE5A 💬 D02229 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
16 cGMP-PKG signaling pathway 💬
 1件: PDE5A 💬 D08514 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
17 Chagas disease 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
18 Chemical carcinogenesis - reactive oxygen species 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
19 Chemical carcinogenesis - receptor activation 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
20 Circadian rhythm 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
21 Circadian rhythm 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
22 Cytokine-cytokine receptor interaction 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
23 Drug metabolism - cytochrome P450 💬
 3件: ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole 1件: 301 💬
24 EGFR tyrosine kinase inhibitor resistance 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
25 Fatty acid degradation 💬
 3件: ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole 1件: 301 💬
26 Fluid shear stress and atherosclerosis 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
27 Fluid shear stress and atherosclerosis 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
28 Fluid shear stress and atherosclerosis 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
29 Focal adhesion 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
30 FoxO signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
31 FoxO signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
32 Glucagon signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
33 Glucagon signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
34 Glycolysis / Gluconeogenesis 💬
 3件: ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole 1件: 301 💬
35 Herpes simplex virus 1 infection 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
36 HIF-1 signaling pathway 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
37 HIF-1 signaling pathway 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
38 Human cytomegalovirus infection 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
39 Human papillomavirus infection 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
40 Hypertrophic cardiomyopathy 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
41 Hypertrophic cardiomyopathy 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
42 Inflammatory bowel disease 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
43 Influenza A 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
44 Insulin resistance 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
45 Insulin resistance 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
46 Insulin signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
47 Insulin signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
48 JAK-STAT signaling pathway 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
49 Kaposi sarcoma-associated herpesvirus infection 💬
 1件: IFNGR1 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
50 Kaposi sarcoma-associated herpesvirus infection 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
51 Leishmaniasis 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
52 Longevity regulating pathway 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
53 Longevity regulating pathway 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
54 Longevity regulating pathway - multiple species 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
55 Longevity regulating pathway - multiple species 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
56 MAPK signaling pathway 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
57 Metabolic pathways 💬
 3件: ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole 1件: 301 💬
58 Metabolic pathways 💬
 1件: PDE5A 💬 D02229 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
59 Metabolic pathways 💬
 1件: PDE5A 💬 D08514 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
60 Metabolism of xenobiotics by cytochrome P450 💬
 3件: ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole 1件: 301 💬
61 MicroRNAs in cancer 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
62 mTOR signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
63 mTOR signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
64 Natural killer cell mediated cytotoxicity 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
65 Necroptosis 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
66 Non-alcoholic fatty liver disease 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
67 Non-alcoholic fatty liver disease 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
68 Osteoclast differentiation 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
69 Oxytocin signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
70 Oxytocin signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
71 Pancreatic cancer 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
72 Pathways in cancer 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
73 Pathways in cancer 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
74 PD-L1 expression and PD-1 checkpoint pathway in cancer 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
75 PI3K-Akt signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
76 PI3K-Akt signaling pathway 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
77 PI3K-Akt signaling pathway 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
78 Proteoglycans in cancer 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
79 Purine metabolism 💬
 1件: PDE5A 💬 D02229 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
80 Purine metabolism 💬
 1件: PDE5A 💬 D08514 💬 Sildenafil 17件:  6 , 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301 💬
81 Pyruvate metabolism 💬
 3件: ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole 1件: 301 💬
82 Rap1 signaling pathway 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
83 Ras signaling pathway 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
84 Relaxin signaling pathway 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
85 Renal cell carcinoma 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
86 Retinol metabolism 💬
 3件: ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole 1件: 301 💬
87 Rheumatoid arthritis 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬
88 Th1 and Th2 cell differentiation 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
89 Th17 cell differentiation 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
90 Thermogenesis 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
91 Thermogenesis 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
92 Tight junction 💬
 2件: PRKAA1, PRKAA2 💬 D00944 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
93 Tight junction 💬
 2件: PRKAA1, PRKAA2 💬 D04966 💬 Metformin 24件:  2 ,  6 ,  8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301 💬
94 Toxoplasmosis 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
95 Tuberculosis 💬
 2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
96 Tyrosine metabolism 💬
 3件: ADH1A, ADH1B, ADH1C 💬 D00707 💬 Fomepizole 1件: 301 💬
97 VEGF signaling pathway 💬
 1件: VEGFA 💬 D05697 💬 Ranibizumab 4件: 34, 166, 227, 301 💬

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